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Risk Factors For Bacteremia In Children With Febrile Neutropenia, Soner Sertan Kara, Hasan Tezer, Meltem Polat, Burcu Ceylan Cura Yayla, Tuğba Bedi̇r Demi̇rdağ, Arzu Okur, Ali̇ Fettah, Sali̇ha Kanik Yüksek, Anil Tapisiz, Zuhre Kaya, Namik Özbek, İdi̇l Yeni̇cesu, Hüsni̇ye Neşe Yarali, Ülker Koçak Jan 2019

Risk Factors For Bacteremia In Children With Febrile Neutropenia, Soner Sertan Kara, Hasan Tezer, Meltem Polat, Burcu Ceylan Cura Yayla, Tuğba Bedi̇r Demi̇rdağ, Arzu Okur, Ali̇ Fettah, Sali̇ha Kanik Yüksek, Anil Tapisiz, Zuhre Kaya, Namik Özbek, İdi̇l Yeni̇cesu, Hüsni̇ye Neşe Yarali, Ülker Koçak

Turkish Journal of Medical Sciences

Background/aim: Bacteremia remains an important cause of morbidity and mortality during febrile neutropenia (FN) episodes. We aimed to define the risk factors for bacteremia in febrile neutropenic children with hemato-oncological malignancies. Materials and methods: The records of 150 patients aged ?18 years who developed FN in hematology and oncology clinics were retrospectively evaluated. Patients with bacteremia were compared to patients with negative blood cultures.Results: The mean age of the patients was 7.5 ± 4.8 years. Leukemia was more prevalent than solid tumors (61.3% vs. 38.7%). Bacteremia was present in 23.3% of the patients. Coagulase-negative staphylococci were the most frequently isolated …


Ifn-Γ Stimulated Dental Follicle Mesenchymal Stem Cells Regulate Activated Lymphocyte Response In Rheumatoid Arthritis Patients In Vitro, Noushin Zibandeh, Deni̇z Genç, Güzi̇de Nevsun İnanç, Rafi̇ Haner Di̇reskeneli̇, Tunç Akkoç Jan 2019

Ifn-Γ Stimulated Dental Follicle Mesenchymal Stem Cells Regulate Activated Lymphocyte Response In Rheumatoid Arthritis Patients In Vitro, Noushin Zibandeh, Deni̇z Genç, Güzi̇de Nevsun İnanç, Rafi̇ Haner Di̇reskeneli̇, Tunç Akkoç

Turkish Journal of Medical Sciences

Background/aim: Multipotent mesenchymal stem cells (MSCs) have been investigated in autoimmune diseases such as rheumatoid arthritis (RA) due to their immunomodulatory and regenerative properties. In this study, their immunosuppressive effects on peripheral blood mononuclear cells (PBMC) of RA patients were studied.Materials and methods: Dental follicle stem cells (DFSCs) were isolated from follicle tissue in the orofacial region. Characterization and multipotency analyses were performed. Lymphocytes were isolated from peripheral venous blood of RA patients (n = 5) and healthy individuals (n = 5). DFSCs were preincubated with IFN-γ for 48 h. PBMCs of RA patients and healthy individuals were separately cultured …


Evaluation Of Cancer Risk In Patients With Periodontal Diseases, Deni̇z Can Güven, Ömer Di̇zdar, Abdullah Cevdet Akman, Ayşe Ezel Berker, Emre Yekedüz, Furkan Ceylan, Batuhan Başpinar, Ilgin Akbiyik, Burak Yasi̇n Aktaş, Deni̇z Yüce, Mustafa Erman, Kadi̇r Mutlu Hayran Jan 2019

Evaluation Of Cancer Risk In Patients With Periodontal Diseases, Deni̇z Can Güven, Ömer Di̇zdar, Abdullah Cevdet Akman, Ayşe Ezel Berker, Emre Yekedüz, Furkan Ceylan, Batuhan Başpinar, Ilgin Akbiyik, Burak Yasi̇n Aktaş, Deni̇z Yüce, Mustafa Erman, Kadi̇r Mutlu Hayran

Turkish Journal of Medical Sciences

Background/aim: In this study, we aimed to assess the cancer risk among patients with periodontal disease.Materials and methods: Patients diagnosed with periodontal diseases at Hacettepe University between 2007 and 2012 were included and data on the diagnosis of any cancer after periodontal disease were collected from patient files. The age- and sex-standardized incidence rates (SIRs) were calculated using Turkish National Cancer Registry 2013 data.Results: A total of 5199 patients were included. Median follow-up was 7.2 years. Patients with periodontal diseases had 17% increased risk of cancer compared with the expected counts for the corresponding age and sex groups (SIR: 1.17; …


The Effects Of Cervical Kinesiotaping On Neck Pain, Range Of Motion, And Disability In Patients Following Thyroidectomy: A Randomized, Double-Blind, Sham-Controlled Clinical Trial, Aysun Genç, Süleyman Utku Çeli̇k, Volkan Genç, Derya Öztuna, Bi̇rkan Sonel Tur Jan 2019

The Effects Of Cervical Kinesiotaping On Neck Pain, Range Of Motion, And Disability In Patients Following Thyroidectomy: A Randomized, Double-Blind, Sham-Controlled Clinical Trial, Aysun Genç, Süleyman Utku Çeli̇k, Volkan Genç, Derya Öztuna, Bi̇rkan Sonel Tur

Turkish Journal of Medical Sciences

Background/aim: This was a randomized, double-blind, sham-controlled study.Thyroidectomy is a frequently performed surgical procedure and head and neck extension during this operation facilitates surgery. Patients may experience postoperative neck pain and cervical range of motion (ROM) limitation due to the surgical position following thyroidectomy. It was aimed herein to investigate the short-term effects of kinesiotaping(KT) applied to the cervical spine on neck pain, ROM, and disability in patients following thyroidectomy. Materials and methods: A total of 74 patients were randomly assigned to be treated with either KT (Group 1, n = 37) or sham taping (Group 2, n = 37) …


Association Of Common Il-10 Promoter Gene Variants With The Susceptibility To Head And Neck Cancer In Tunisia, Lamia Makni, Cherif Ben Hamda, Abrar Al Ansari, Oussema Souaiai, Ezzedine Gazouani, Amel Mezlini, Wassim Y. Almawi, Besma Yacoubi-Loueslati Jan 2019

Association Of Common Il-10 Promoter Gene Variants With The Susceptibility To Head And Neck Cancer In Tunisia, Lamia Makni, Cherif Ben Hamda, Abrar Al Ansari, Oussema Souaiai, Ezzedine Gazouani, Amel Mezlini, Wassim Y. Almawi, Besma Yacoubi-Loueslati

Turkish Journal of Medical Sciences

Background/aim: We investigated the association of three IL-10 promoter single-nucleotide polymorphisms and altered IL-10 plasma levels with the risk of head and neck cancer (HNC). Materials and methods: Study subjects comprised 194 HNC patients [137 nasopharyngeal cancer (NPC) and 57 laryngeal cancer (LC)], and 263 healthy controls. Genotyping of rs1800896 (-1082A>G), rs1800871 (-819C>T), and rs1800872 (-592A>C) IL-10 variants was performed by real-time PCR; IL-10 levels were measured by enzyme amplified immuno sensitivity assay (EAISA). Results: Carriage of rs1800896 A/A genotype was more frequent in the HNC and NPC cases, but was less frequent in the controls than …


Accumulation And Histological Transformation In The Gills, Liver, Muscles, And Skin In Oreochromis Niloticus Induced By Mercury, Khalid Abdullah Al-Ghanim, Zubair Ahmad, Hmoud Fares Alkahem Al-Balawi, Fahad Al-Misned, Shahid Mahboob, El Amin Mohammad Suliman Jan 2019

Accumulation And Histological Transformation In The Gills, Liver, Muscles, And Skin In Oreochromis Niloticus Induced By Mercury, Khalid Abdullah Al-Ghanim, Zubair Ahmad, Hmoud Fares Alkahem Al-Balawi, Fahad Al-Misned, Shahid Mahboob, El Amin Mohammad Suliman

Turkish Journal of Veterinary & Animal Sciences

Specimens of Oreochromis niloticus (One control and 3 experimental groups) were fed diets mixed with different doses of mercury (control group = free of mercury; group 1 = 500 mg/kg; group 2 = 750 mg/kg, and group 3 = 1000 mg/kg) for 60 days in order to study its accumulation and histopathological alterations in the liver, gills, skeletal muscles, and skin. The results obtained revealed that mercury accumulation was significantly (P < 0.05) high in the liver and gills compared to the muscles and skin. The order of accumulation in these organs revealed to be liver > gills > muscles > skin. The fish fed various doses of mercury also showed histological alterations in these organs. Epithelial lifting and epithelial hypertrophy were seen in the gills of the …


The Results Of Nasopharyngeal Cancer Patients Treated By Simultaneous Integrated Boost Technique And Concomitant Chemotherapy, Mehmet Fai̇k Çeti̇ndağ, Ati̇ye Yilmaz Özsavran, Bülent Yalçin, İclal Çeti̇ndağ, Şeyda Türkölmez, Karabeki̇r Ercan, Di̇nçer Yeğen Jan 2019

The Results Of Nasopharyngeal Cancer Patients Treated By Simultaneous Integrated Boost Technique And Concomitant Chemotherapy, Mehmet Fai̇k Çeti̇ndağ, Ati̇ye Yilmaz Özsavran, Bülent Yalçin, İclal Çeti̇ndağ, Şeyda Türkölmez, Karabeki̇r Ercan, Di̇nçer Yeğen

Turkish Journal of Medical Sciences

Background/aim: To assess the efficacy and side effects of concurrent weekly chemotherapy and radiotherapy with simultaneous integrated boost (SIB) technique for nasopharyngeal cancer (NPC). Materials and methods: A total of 51 consecutive patients with diagnosis of NPC were treated between February 2010 and December 2015. The median dose for PTV70 (range: 60-82) was given in 33 fractions (range: 31-35). Forty-five of the patients received concomitant weekly chemotherapy between 3-7 cycles (median 6). Eleven patients received neoadjuvant and thirty-nine patients received adjuvant chemotherapy. Results: At a median follow-up 43 months (range: 2-76) the estimated 5-year overall survival and disease-free survival were …


Three Dimensional Printing And Biomaterials In The Repairment Of Bone Defects; Hydroxyapatite Pla Filaments, İsmai̇l Kaya, Meryem Cansu Şahi̇n, İlker Deni̇z Ci̇ngöz, Nevi̇n Aydin, Murat Atar, Ceren Kizmazoğlu, Sali̇h Kavuncu, Hasan Emre Aydin Jan 2019

Three Dimensional Printing And Biomaterials In The Repairment Of Bone Defects; Hydroxyapatite Pla Filaments, İsmai̇l Kaya, Meryem Cansu Şahi̇n, İlker Deni̇z Ci̇ngöz, Nevi̇n Aydin, Murat Atar, Ceren Kizmazoğlu, Sali̇h Kavuncu, Hasan Emre Aydin

Turkish Journal of Medical Sciences

Background/aim: Application fields of bone tissue engineering studies continue to expand. New biocompatible materials aimed to improve bone repairment and regeneration of implants are being discovered everyday by scientists, engineers, and surgeons. Our objective in this study is to combine polylactic acid which is a polymer with hydroxyapatite in the repairment of bone defects considering the increased need by medical application fields. Materials and methods: After 750 g of PLA with a diameter of 2.85 mm was granulated into minimum particles, these particles were homogenously mixed with hydroxyapatite prepared in laboratory environment. Using this mixture, HA-PLA filament with a diameter …


Animal Remains Of Alaybeyi Höyük, Abu Bakar Siddiq Jan 2019

Animal Remains Of Alaybeyi Höyük, Abu Bakar Siddiq

Turkish Journal of Veterinary & Animal Sciences

This paper presents the zooarchaeological observations on animal remains of Alaybeyi Höyük unearthed from 2016 and 2017 excavation sessions. Dated to 4721-4553 cal. BC, Alaybeyi stands so far as the oldest archaeological settlement discovered in northeast Anatolia. Therefore, the faunal assemblage at Alaybeyi offers great opportunity to study the status of animals and their relationships with humans in the largely unexplored Kars-Erzurum plateau covering a period from the Chalcolithic to Late Iron Age. Taxonomic and osteometric analyses show that, like the present day, cattle were dominant over caprines, revealing extensive cattle pastoralism in the region for at least about 7 …


A Nasopharyngeal Inflammatory Polyp In A Cat: Histopathology, Immunohistochemistry, And Ct Scan Findings, Hamid Reza Moosavian, Hamideh Esmaeilzadeh, Ramesh Vahabi, Rana Vafaei, Mohammad Reza Esmailinejad Jan 2019

A Nasopharyngeal Inflammatory Polyp In A Cat: Histopathology, Immunohistochemistry, And Ct Scan Findings, Hamid Reza Moosavian, Hamideh Esmaeilzadeh, Ramesh Vahabi, Rana Vafaei, Mohammad Reza Esmailinejad

Turkish Journal of Veterinary & Animal Sciences

The etiology of feline nasopharyngeal inflammatory polyps (FNIPs) has not been completely understood. To the best of our knowledge, there is no study having evaluated the immunohistochemical features of FNIPs. More studies about the histopathological characteristics of such lesions can play a pivotal role in further understanding the disease. We present the clinical manifestations, computed tomography (CT) scan, histopathology, and immunohistochemistry features of a FNIP in a 7-year-old male neutered domestic shorthair cat. CT scan examination showed nasopharyngeal space occupation with some parts of destruction in nasal cavity. Immunohistochemical study of the sections demonstrated the presence of CD3$^{+}$ lymphocytes, and …


Morphometric Analysis Of The Skulls Of Domestic Cattle (Bos Taurus L.) And Water Buffalo (Bubalus Bubalis L.) In Turkey, Ermi̇ş Özkan, Abu Bakar Siddiq, Ki̇fayet Oya Kahveci̇oğlu, Muhsi̇n Öztürk, Vedat Onar Jan 2019

Morphometric Analysis Of The Skulls Of Domestic Cattle (Bos Taurus L.) And Water Buffalo (Bubalus Bubalis L.) In Turkey, Ermi̇ş Özkan, Abu Bakar Siddiq, Ki̇fayet Oya Kahveci̇oğlu, Muhsi̇n Öztürk, Vedat Onar

Turkish Journal of Veterinary & Animal Sciences

A total of 20 domestic cattle (Bos taurus L.) and 15 water buffalo (Bubalis bubalis L.) skulls were analyzed in this study. All of the specimens belonged to female individuals. Using a total of 27 craniometric measurements from each of the skulls, 9 indices were calculated. Although there were statistically significant differences between the linear measurements of the skulls of both species, while calculating the indices with their ratios, the values of the measurements of the facial area were determinative in the craniology. Among these indices, the facial index 1 value was statistically significant (P < 0.01) in the comparison of these two species. On the other hand, while considering the orbit and foramen magnum measurements, in contrast with the transversal measurement, the height was more determinant for their index and form.


Phenotypic Characterization And Differentiation Of Mesenchymal Stem Cells Originating From Adipose Tissue, Ece Çerçi̇, Hati̇ce Erdost Jan 2019

Phenotypic Characterization And Differentiation Of Mesenchymal Stem Cells Originating From Adipose Tissue, Ece Çerçi̇, Hati̇ce Erdost

Turkish Journal of Veterinary & Animal Sciences

Stem cells are known as undifferentiated cells that are capable of divisions and self-renewal over an extended period. Adipose tissue-derived mesenchymal stem cells (ADSCs) are known to differentiate into many different organ and tissue cells. The purpose of this study was to characterize adipose tissue-derived mesenchymal stem cells in detail based on the expression status of certain surface markers and differentiation stages for clinical and laboratory applications. The migrating phase and mitotic property of the cells from adipose tissue were assessed under a microscope. Cell counting was performed during the first, second, and third passages. The cells were differentiated into …