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Effect Of Histatin- And Statherin-Derived Engineered Salivary Peptides On Streptococcus Mutans Adhesion And On Enamel Demineralization Provoked By Cariogenic Biofilms, Lina Maria Marin
Electronic Thesis and Dissertation Repository
Dental biofilm is formed onto dental surfaces covered by a layer of specific salivary proteins and peptides named acquired enamel pellicle (AEP). It was previously demonstrated that the statherin- and histatin-derived engineered salivary peptides DR9-DR9 and DR9-RR14 were able to reduce enamel demineralization and displayed antimicrobial activity against Streptococcus mutans, respectively. However, these studies were carried under experimental conditions that did not mimic caries development induced by biofilm and sucrose exposure, the most cariogenic dietary sugar. In this thesis we assessed the effect of the engineered salivary peptides on 1) the adherence of S. mutans to hydroxyapatite (HAp), and …
Novel Protective Salivary Peptides And The Chitosan Nanoparticles Delivery System, Flavia Zaidan Cardoso Salina
Novel Protective Salivary Peptides And The Chitosan Nanoparticles Delivery System, Flavia Zaidan Cardoso Salina
Electronic Thesis and Dissertation Repository
As a result of its protein composition, saliva performs many essential functions that contribute to oral homeostasis. However, salivary proteins suffer quick degradation in the oral cavity, which decreases the protective potential of that fluid (Chapter 2). Using scanning electron microscopy (SEM), we evaluated the effect of our novel salivary peptides DR9, DR9-DR9, DR9-RR14 and RR14 on the crystallization of calcium oxalate (CaOx). All peptides containing DR9 showed significant inhibitory effect on the crystallization of CaOx, whereas RR14 showed no effect (Chapter 3). Next, we tested the adsorption behavior of our chitosan nanoparticles (CHNP) delivery system to hydroxyapatite (HA) surface …
Identification Of The Salivary Proteome In Children Throughout The Course Of Dental Eruption, Nada Tabbara
Identification Of The Salivary Proteome In Children Throughout The Course Of Dental Eruption, Nada Tabbara
Electronic Thesis and Dissertation Repository
The salivary proteome is recognized as a valuable source of potential oral and systemic disease biomarkers. Major efforts in salivary research have been dedicated to identify and characterize salivary proteins present in saliva using both classical biochemical methods and proteomics approaches in adults. Despite considerable research on the salivary proteome, little attention has been given to the changes in the salivary proteome occurring in children, specifically from 0-3 years of age. Through the use of anionic PAGE, SDS PAGE, HPLC and MS/MS, salivary protein profiles in children before, during and after dental eruption were compared with edentulous adult controls. We …