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Effects Of Prenatal Bisphenol A Exposure On Adrenal Gland Development And Steroidogenic Function, Samantha Medwid
Effects Of Prenatal Bisphenol A Exposure On Adrenal Gland Development And Steroidogenic Function, Samantha Medwid
Electronic Thesis and Dissertation Repository
Developmental exposure to bisphenol A (BPA), a ubiquitous endocrine disrupting chemical, is associated with organ dysfunction and diseases in adulthood. However, little is known about its effects on the adrenal glands. Therefore, this thesis addresses this important question using both in vivo and in vitro approaches. BPA at environmentally relevant doses was administrated via diet to pregnant mice from embryonic day 7.5 to birth, following which mice were switched to a standard chow. At two months postnatally, adrenal glands and blood samples were collected from adult mouse offspring for structural and functional analysis. I found that: (a) BPA increased adrenal …
Effects Of Prenatal Exposure To Bisphenol A On Fetal Lung Development, Ayten Hijazi
Effects Of Prenatal Exposure To Bisphenol A On Fetal Lung Development, Ayten Hijazi
Electronic Thesis and Dissertation Repository
Prenatal exposure to bisphenol A (BPA), one of the most prevalent endocrine disrupting chemicals, is associated with lung dysfunction and diseases in later life. However, it is unknown if this association has a fetal origin. In this thesis, a series of in vivo and in vitro experiments were conducted to determine the effects of prenatal exposure to BPA on fetal lung development, and define the underlying molecular mechanisms. Environmentally relevant doses of BPA were administered to pregnant mice via diet from embryonic day (E) 7.5 to 18.5. Fetal lungs were analyzed at E18.5 for changes in structure and expression of …