Digital Commons Network^™

Comparison Of Treatment Effects Of The Forsus Fatigue Resistance Device In Class Ii Patients With Different Underlying Vertical Skeletal Patterns, Michelle C. Watroba

Electronic Thesis and Dissertation Repository

The purpose of this study was to evaluate the differences in dental and skeletal changes induced by the Forsus^TM Class II dentoalveolar corrector in Class II patients with varying vertical skeletal growth patterns. The sample consisted of 26 (mean age 12.9 ± 1.3 years) Brachyfacial (BF) (SN-MP < 30^o) consecutively treated Forsus subjects, 16 (mean age 13.1 ± 0.8 years) BF untreated Class II subjects (control subjects), 12 (mean age 12.3 ± 1.2 years) Nonbrachyfacial (NBF) (SN-MP ≥ 30^o) consecutively treated Forsus subjects, and 8 (mean age 13.2 ± 0.9 years) NBF untreated Class II subjects (control). …

Nasal Morphology As A Predictor Of Craniofacial Growth Direction, Christos Papadopoulos

Electronic Thesis and Dissertation Repository

It is important for an orthodontist to predict growth related changes and thereby appropriately time orthodontic treatment using the vertical indicators currently available. A potential predictor of craniofacial growth direction that has been discussed yet remains scientifically unexplored is nasal morphology. The objectives of this study are to determine if a difference in pre-adolescent nasal contour exists between post-adolescent normodivergent and hyperdivergent subjects, and if nasal contour morphology in pre-adolescent females is a reliable indicator of future craniofacial growth direction. A significant difference in pre-adolescent nasal contour morphology was found between normodivergent and hyperdivergent groups. A pre-adolescent nasal contour elevation …

A Longitudinal Study To Investigate Changes In Functional Ability And Concerns In Head Neck Cancer Patients Undergoing Neck Dissection, Mariya Ehsan

Electronic Thesis and Dissertation Repository

Introduction:

The study investigated changes of shoulder/neck range of motion (ROM), shoulder strength, patient concerns and quality of life at pre-surgery and 1 month following neck dissection surgery.

Method:

Participants were 30 head and neck cancer patients selected for unilateral neck dissection. Shoulder/neck ROM and shoulder strength were measured at pre-surgery and 1 month post-surgery. The Patient Concerns Inventory-Level of Importance, University of Washington Quality of Life, Shoulder Pain and Disability Index and Neck Dissection Impairment Index were completed at the same time periods.

Result:

A significant drop in ROM and strength were found after surgery. Patients’ concerns changed over …

Standing Up For Student Health: An Application Of The Health Action Process Approach For Reducing Student Sedentary Behavior., Wuyou -. Sui

Electronic Thesis and Dissertation Repository

Sedentary behavior (SB) has been associated with chronic diseases, such as Hypertension and Obesity; the risk appears greater the longer one engages in SB. University Students are a high-risk population for excessive SB due to academic responsibilities. Increasing frequency/length of breaks from sitting is an effective way to attenuate effects of SB. The Health Action Process Approach (HAPA) is a proven health behavior change model for behaviors like nutrition, but has yet to show effectiveness for increasing non-sedentary behaviors. Forty-five university students (12 Males, Mean age 23.3) were randomized into HAPA-intervention (sedentary behavior) or HAPA-control (nutrition) groups. Occupational Student and …

The Effects Of Manual Tooth Brushing On Parotid And Submandibular/Sublingual Gland Salivary Flow Rates In Healthy Young And Older Adults, Kristen M. Trottier

Electronic Thesis and Dissertation Repository

Saliva is crucial for the maintenance of oral health. Individuals with reduced salivary flow may experience a distortion in taste, difficulty swallowing, and impaired articulation of speech. Research has shown that tooth brushing increases whole salivary flow rates in older adults. It is important to determine whether this increase results from the modulation of parotid gland salivary flow, submandibular and sublingual gland salivary flow, or both. Saliva produced from the parotid gland aids in digestive processes, while saliva secreted from the submandibular and sublingual glands promotes protection of the oral cavity. A within-subjects methodology was used to examine the effects …

Cal And Magi Pdz Protein Regulation Of Crfr1 And 5-Ht2ar Trafficking And Signaling, Maha Mahmoud Hammad

Electronic Thesis and Dissertation Repository

PDZ (PSD95/Disc Large/Zona Occludens) domain-containing proteins are scaffolding proteins that play important roles in regulating the activity of G protein-coupled receptors. Corticotropin Releasing Factor Receptor 1 (CRFR1) and Serotonin 2A Receptor (5-HT_2AR) are two GPCRs that are commonly associated with mental disorders. Both receptors also contain a class I PDZ-binding motif at the carboxyl terminal tail. In the first chapter, we investigate the effects of CAL (CFTR-associated ligand) on regulating the trafficking and signaling of CRFR1. We demonstrate a role for CAL in inhibiting CRFR1 endocytosis, cell surface expression, and CRF-mediated ERK1/2 signaling via the CRFR1 PDZ-binding motif. …

Protective Benefits Of Hydrogen Sulfide Treatment During Renal Transplantation, Ian Lobb

Electronic Thesis and Dissertation Repository

Ischemia/reperfusion injury (IRI) is inherent to renal transplantation (RTx) and is initiated when blood supply is necessarily removed during organ procurement (ischemia) and subsequently restored upon engraftment (reperfusion). During renal ischemia, ATP depletion causes tubular epithelial cell (TEC) injury and subsequent release of pro-inflammatory mediators. Upon reperfusion, influx of O₂ causes reactive oxygen species (ROS) production and infiltration of innate immune cells which release damaging ROS and proteases. Prolonged periods of IRI are associated with increased risk of delayed graft function (DGF) and decreased long-term graft survival. The endogenously produced gasotransmitter, hydrogen sulfide (H₂S), has recently been …

A Gender-Sensitized Weight Loss And Healthy Lifestyle Program For Overweight And Obese Male Hockey Fans: Effects On Dietary Behaviours, Ashleigh De Cruz

Electronic Thesis and Dissertation Repository

BACKGROUND: Male dietary behaviours have often been associated with overweightness and obesity. Although little research exists to help prevent the problem, this can somewhat be explained by the lack of men engaging in healthy eating and lifestyle change. A gender-sensitized intervention study using hockey as a draw to participate may positively change dietary behaviours and associated health outcomes. METHODS: A 12 week, 12 session, weight loss and healthy lifestyle intervention program was conducted in which overweight and obese male fans of a local hockey team were coached to adopt healthy eating and lifestyle behaviour changes in collaboration with …

Inequalities In Social Determinants Of Health In The Ontario Transgender Population, Rachel E. Giblon

Electronic Thesis and Dissertation Repository

This study examined how everyday living conditions known to influence health outcomes – social determinants of health – differ between transgender Ontarians and the general Ontario population. Previously collected data on social determinants, demographics, health, and health care from trans (n=433) and non-trans individuals (n=39980) living in Ontario were used. Standardized risk differences showed that significantly more trans individuals were underpaid and underemployed, unable to complete their post-secondary education, and had experienced food insecurity, social exclusion and unmet health care needs. Differences were largest comparing trans men to cisgender men of the same age distribution. Findings from this study identified …

The Consequences Of Oromandibular Dystonia On Communicative Participation: A Qualitative Study Of The Insider's Experiences, Lauren Siegel

Electronic Thesis and Dissertation Repository

The purpose of this study was to explore the consequences of oromandibular dystonia (OMD) on communicative participation from the insider’s perspective. Qualitative research methods were used to obtain a self-reported account of the experience of living with OMD. Eight individuals with OMD and dysarthria participated in face-to-face phenomenological interviews. Interviews were transcribed from audio recordings and coded using coding software. The codes were then grouped into larger thematic categories based on salience. Results showed that communicative participation is affected by multiple physical, social, and emotional factors caused by OMD. Furthermore, OMD can have significant effects on an individual’s job, family, …

Effects Of Prenatal Exposure To Bisphenol A On Fetal Lung Development, Ayten Hijazi

Electronic Thesis and Dissertation Repository

Prenatal exposure to bisphenol A (BPA), one of the most prevalent endocrine disrupting chemicals, is associated with lung dysfunction and diseases in later life. However, it is unknown if this association has a fetal origin. In this thesis, a series of in vivo and in vitro experiments were conducted to determine the effects of prenatal exposure to BPA on fetal lung development, and define the underlying molecular mechanisms. Environmentally relevant doses of BPA were administered to pregnant mice via diet from embryonic day (E) 7.5 to 18.5. Fetal lungs were analyzed at E18.5 for changes in structure and expression of …

Characterization Of Microbial Communities In The Mammary Glands And The Influence Of This Microbiota On Health And Disease, Camilla Urbaniak

Electronic Thesis and Dissertation Repository

The collective microbes and their genomic activity within us, referred to as the human microbiome, is crucial in maintaining health, and disruptions in composition and activity have been associated with various diseases. Considering the importance of breast milk in neonatal development and the high rate of breast cancer in women, the objective of my thesis was to obtain a comprehensive analysis of the microbiota of the mammary glands and to examine the influence of these organisms on health and disease.

Human milk is an important source of bacteria for the developing infant. While a variety of studies over the last …

Access To Care And The Impact Of Inequality Among Individuals With A History Of Mental Illness, Heather Atyeo

Electronic Thesis and Dissertation Repository

Using an Intersectionality framework, a secondary analysis of pre-existing data from the CURA2 Poverty and Social Inclusion study (Forchuk et al., 2010-2015) was used to explore the relationship between experiences of oppression and self-rated health among a cross-section of 293 community dwelling participants with a mental illness. Binary logistic regression was used to estimate the association between self-rated health and social identity (gender, ethnicity, education, homelessness, employment, disability); health care access was tested for both mediating and moderating effects. The final model explained between 18.9-25.2% of the variance in self-rated health; four independent variables made unique statistically significant contributions to …