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Immunohistochemical Studies Of Expression And Correlation Of Osteopontin, Cd44, And Integrin Αvβ3 In Selected Benign And Malignant Salivary Gland Tumours, Tommy Fok
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Osteopontin (OPN) is a phosphorylated acidic glycoprotein that has been shown to play a vital role in tumourigenesis and metastases. The objective of this study was to determine the expression of OPN and its receptors (CD44 and integrin αvβ3) in several salivary gland cancers, and assess its clinical correlations.
Immunohistochemical techniques were used to semi-quantify the level of OPN expression and its receptors in normal salivary glands and different types of salivary gland tumour.
Our results show that in tumours of salivary gland origin, higher levels of OPN were detected in tumours which were malignant compared …