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Medicine and Health Sciences

Electronic Thesis and Dissertation Repository

2012

Cytokines

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Modulatory Effects Of North American Ginseng Extracts On Human Innate And Adaptive Immune Responses, Holly Rebecca Lemmon Feb 2012

Modulatory Effects Of North American Ginseng Extracts On Human Innate And Adaptive Immune Responses, Holly Rebecca Lemmon

Electronic Thesis and Dissertation Repository

Ginseng has played a vital role in traditional Chinese medicine for thousands of years. There are 22 variants of ginseng including North American ginseng (Panax quinquefolius) and Asian ginseng (Panax ginseng). The use of North American ginseng has increased dramatically and there is a strong need to understand its immunomodulatory effects. This is because the majority of current research focusing on the Asian ginseng variant. Human peripheral blood mononuclear cells (PBMC) were used to test the immunomodulatory properties of 3 North American ginseng extracts, COLD-FX® and deglycosylated individual ginsenosides. Microarray analysis of PBMC exposed to …