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Insulin-Like Growth Factor 1 And Transforming Growth Factor-Β Stimulate Cystine/Glutamate Exchange Activity In Dental Pulp Cells, Katherine Pauly, Kymberly Fritz, Alyssa Furey, Doug Lobner
Insulin-Like Growth Factor 1 And Transforming Growth Factor-Β Stimulate Cystine/Glutamate Exchange Activity In Dental Pulp Cells, Katherine Pauly, Kymberly Fritz, Alyssa Furey, Doug Lobner
Biomedical Sciences Faculty Research and Publications
Introduction
The growth factors insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β) are protective to dental pulp cells in culture against the toxicity of the composite materials Durafill VS and Flow Line (Henry Schein Inc, New York, NY). Because the toxicity of these materials is mediated by oxidative stress, it seemed possible that the protective effects of IGF-1 and TGF-β were through the enhancement of an endogenous antioxidant mechanism.
Methods
We used cultured dental pulp cells to determine the mechanism of the protective effects of IGF-1 and TGF-β, focusing on the glutathione system and the role of cystine/glutamate exchange …
Adrenal Activity During Repeated Long-Access Cocaine Self-Administration Is Required For Later Crf-Induced And Crf-Dependent Stressor-Induced Reinstatement In Rats, Evan N. Graf, Michael A. Hoks, Jean Baumgardner, Jose Sierra, Oliver Vranjkovic, Colin Bohr, David A. Baker, John R. Mantsch
Adrenal Activity During Repeated Long-Access Cocaine Self-Administration Is Required For Later Crf-Induced And Crf-Dependent Stressor-Induced Reinstatement In Rats, Evan N. Graf, Michael A. Hoks, Jean Baumgardner, Jose Sierra, Oliver Vranjkovic, Colin Bohr, David A. Baker, John R. Mantsch
Biomedical Sciences Faculty Research and Publications
Understanding the neurobiological processes that contribute to the establishment and expression of stress-induced regulation of cocaine use in addicted individuals is important for the development of new and better treatment approaches. It has been previously shown that rats self-administering cocaine under long-access conditions (6 h daily) display heightened susceptibility to the reinstatement of extinguished cocaine seeking by a stressor, electric footshock, or i.c.v. administration of the stressor-responsive neuropeptide, corticotropin-releasing factor (CRF). This study tested the hypothesis that adrenal responsiveness during earlier long-access cocaine self-administration (SA) is necessary for the establishment of later CRF-dependent stress-induced reinstatement. Reinstatement by footshock, but not …