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Repeated N-Acetylcysteine Administration Alters Plasticity-Dependent Effects Of Cocaine, Aric Madayag, Doug Lobner, Kristen S. Kau, John R. Mantsch, Omer Abdulhameed, Matthew Hearing, Mark D. Grier, David A. Baker

Biomedical Sciences Faculty Research and Publications

Cocaine produces a persistent reduction in cystine–glutamate exchange via system x_c− in the nucleus accumbens that may contribute to pathological glutamate signaling linked to addiction. System x_c− influences glutamate neurotransmission by maintaining basal, extracellular glutamate in the nucleus accumbens, which, in turn, shapes synaptic activity by stimulating group II metabotropic glutamate autoreceptors. In the present study, we tested the hypothesis that a long-term reduction in system x_c− activity is part of the plasticity produced by repeated cocaine that results in the establishment of compulsive drug seeking. To test this, the cysteine prodrug N-acetylcysteine …

Response To A Retrospective Evaluation Of Crown-Fractured Permanent Teeth Treated In A Pediatric Dentistry Clinic, H. Cem Güngör

School of Dentistry Faculty Research and Publications

No abstract provided.

A Nodular Submental Mass, Yeshwant B. Rawal, Carl M. Allen, John R. Kalmar

School of Dentistry Faculty Research and Publications

A 26-year-old male presented with a 2-month history of a mildly painful, slow growing, nodular mass of the submental region. Examination revealed a 1.5 x 1.0-cm midline swelling of the submental region. The skin over the mass appeared normal. The mass was firm and slightly tender on palpation and appeared to be positioned within the submental space. Intraoral examination did not reveal any obvious pathologic findings and the nearby teeth showed no caries, periodontal disease, or mobility. The patient’s medical history was unremarkable.

Physical Properties Of Denture Base Resins Potentially Resistant To Candida Adhesion, Gunjan Dhir, David W. Berzins, Virendra B. Dhuru, Periathamby A. Raj, Andrew R. Dentino

School of Dentistry Faculty Research and Publications

Purpose: The addition of anionic charge on denture base resins has been shown to inhibit Candida albicans adhesion and to facilitate adsorption of salivary defense molecules. The aim of this study was to evaluate the physical properties of a modified denture base resin for denture fabrication.

Materials and Methods: Specimens made from heat polymerizing resin Lucitone 199 were used as the control group. The two experimental groups, E-10 and E-20, had 10% and 20%, respectively, of the monomer substituted with an experimental phosphate-containing monomer. Flexural strength and modulus, water sorption, solubility, and color stability tests were conducted to ensure compliance …

Management Of Cervical Root Fracture Using Orthodontic Extrusion And Crown Reattachment: A Case Report, Harun Canoglu, H. Cem Güngör, Zafer C. Cehreli

School of Dentistry Faculty Research and Publications

Root fractures involve damage to pulp, cementum, dentin, and periodontal ligaments. These injuries affect 0.5% to 7% of permanent teeth. Cervical root fractures are less frequently seen and have a worse prognosis compared with the fractures in the apical or middle third of the root. This case report describes the treatment of a cervical root fracture in a maxillary central incisor. After removal of the coronal fragment, the root was filled temporarily with calcium hydroxide and orthodontic extrusion was initiated. The remaining root portion was elevated above the epithelial attachment and a successful coronal restoration was made using the natural …

Effect Of Various Curing Lights On The Degree Of Cure Of Orthodontic Adhesives, Markus Niepraschk, Christos Rahiotis, T. Gerard Bradley, Theodore Eliades, George Eliades

School of Dentistry Faculty Research and Publications

Introduction: The purpose of this study was to compare the percentage degree of cure (%DC) of orthodontic adhesive resins irradiated with 3 types of light sources of various intensities: plasma arc, halogen, and light-emitting diode (LED). Methods: Twenty maxillary incisor stainless steel brackets (0.018-in slot) were divided into 4 groups of 5 brackets each. A standardized amount of composite resin was applied to each bracket base, simulating its clinical application. The brackets were light-cured with a halogen light for 20 seconds (10 seconds each from the incisal and cervical bracket edges), an LED light for 20 seconds (10 seconds per …

A Retrospective Evaluation Of Crown-Fractured Permanent Teeth Treated In A Pediatric Dentistry Clinic, H. Cem Güngör, Serdar Uysal, Nil Altay

School of Dentistry Faculty Research and Publications

A retrospective study was carried out on the dental trauma records of 93 patients (55 boys, 38 girls) with 129 crown-fractured teeth. The patients’ average age was 9.57 years (SD 1.57), ranging between 7 and 15 years. Uncomplicated crown facture (comprising enamel–dentin) was the most observed type of injury (n = 107, 83%). Only 15 patients (16.13%) sought treatment in less than 24 h following the injury. Of 41 injured teeth (31.79%) the apices were open at the time of presentation at the clinic. The initial treatment of these injured teeth were interim restoration with acid-etch and composite (69%), …

The Cerebellar Fastigial Nucleus Contributes To Co2-H+ Ventilatory Sensitivity In Awake Goats, P. F. Martino, S. Davis, C. Opansky, Katie L. Krause, Joshua M. Bonis, Lawrence Pan, B. Qian, Hubert V. Forster

Physical Therapy Faculty Research and Publications

The purpose of this study was to test the hypothesis that an intact cerebellar fastigial nucleus (CFN) is an important determinant of CO₂-H⁺ sensitivity during wakefulness. Bilateral, stainless steel microtubules were implanted into the CFN (N = 9) for injection (0.5–10 μl) of the neurotoxin ibotenic acid. Two or more weeks after implantation of the microtubules, eupneic breathing and CO₂-H⁺ sensitivity did not differ significantly (P > 0.10) from pre-implantation conditions. Injection of ibotenic acid (50 mM) did not significantly alter eupneic Pa_CO2 (P > 0.10). The coefficient of variation of …

Shear Bond Strength Comparison Between Two Orthodontic Adhesives And Self-Ligating And Conventional Brackets, Rodney G. Northrup, David W. Berzins, T. Gerard Bradley, William I. Schuckit

School of Dentistry Faculty Research and Publications

Objective: To evaluate and compare the shear bond strengths of two adhesives using two types of brackets: a conventional and a self-ligating bracket system.

Materials and Methods: Sixty extracted human premolars were collected. The premolars were randomly divided into three groups of 20 teeth. All three groups were direct bonded. Groups 1 and 2 used light-cured adhesive and primer (Transbond XT) with a conventional (Orthos) and a self-ligating bracket (Damon 2), respectively. Group 3 used a light-cured primer (Orthosolo) and a light-cured adhesive (Blūgloo) with a self-ligating bracket (Damon 2). The specimens were stored in distilled water at 37°C for …

Myopericytoma Of The Oral Cavity, Vivekanand Datta, Yeshwant B. Rawal, Harry H. Mincer, Mark K. Anderson

School of Dentistry Faculty Research and Publications

Background.

Myopericytoma is a rare mesenchymal neoplasm of pericytic cells demonstrating myoid differentiation. The lesion typically arises within the subcutaneous tissue of the extremities. We report a case that, to the best of our knowledge, is the first case of myopericytoma involving the soft tissue of the oral cavity.

Methods.

A 36-year-old woman had a 5-mm sessile, whitish-pink, firm tongue nodule. The patient underwent excisional biopsy, and histopathologic examination as well as immunohistochemical analysis were performed.

Results.

The differential diagnosis by histologic analysis included solitary fibrous tumor, myofibroma, glomus tumor, and myopericytoma. The results of immunohistochemical analysis, when combined with …

Root Fracture In Immature Tooth: Report Of A Case, H. Cem Güngör, Bülent Büyükgüral, Serdar Uysal

School of Dentistry Faculty Research and Publications

Root fracture injuries affect 0.5–7% of permanent teeth. Although this type of injury is rarely seen in teeth with immature root formation, the prognosis is generally good depending on the site of the fracture. A case report of horizontal root fracture in maxillary central incisor of an 8-year and 3-month-old girl and its treatment was presented.

Traumatic Neuroma Following Sagittal Split Osteotomy Of The Mandible, R. H. Kallal, F. G. Ritto, Luis Eduardo Almeida, D. J. Crofton, G. P. Thomas

School of Dentistry Faculty Research and Publications

A 16-year-old male underwent bilateral sagittal split osteotomy of the mandible to correct a mandibular deficiency. Twenty-one years later, a routine panoramic radiograph revealed a radiolucent lesion on the left side of the mandible. The lesion was biopsied. As the patient did not have symptoms and the lesion was connected to the inferior alveolar nerve, the lesion was not totally excised in order to preserve nerve function. The histological features were consistent with traumatic neuroma, and no further surgical procedure was planned.

Thermal Analysis Of As-Received And Clinically Retrieved Copper-Nickel-Titanium Orthodontic Archwires, Matthew C. Biermann, David W. Berzins, T. Gerard Bradley

School of Dentistry Faculty Research and Publications

Objective: To compare as-received copper-nickel-titanium (CuNiTi) archwires to those used in patients by means of differential scanning calorimetry (DSC). Also, the thermal or phase properties of 27°C, 35°C, and 40°C CuNiTi archwires were studied to ascertain if their properties match those indicated by the manufacturer.

Materials and Methods: Six wires of 27°C, 35°C, and 40°C CuNiTi were tested as-received, and six each of the 27°C and 35°C wires were examined after use in patients for an average of approximately 9 and 7 weeks, respectively. Segments of archwire were investigated by DSC over the temperature range from −100°C to 150°C at …

Continued Professional Competence And Portfolios, Michelle Byrne, Teresa Delarose, Cecil A. King, Jane Stover Leske, Kathryn G. Sapnas, Kathryn Schroeter

College of Nursing Faculty Research and Publications

It is traditionally assumed that licensure of healthcare professionals means that they are minimally competent. Many nursing specialty organizations offer examinations and other processes for certification, suggesting that certification is associated with continued competency. Can standardized examination for certification and continuing education for recertification ensure continued competency? Continuing education and testing provide a limited picture of an individual's knowledge and/or skill acquisition in a limited area at one point in time. However, portfolios promote critical thinking, self-assessment, and individual accountability. A portfolio is a portable mechanism for evaluating competencies that may otherwise be difficult to assess. This article summarizes some …