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Microparticulate Drug Reformulation Using Electrostatic Layer -By -Layer Assembly And Co-Entrapment With Anionic Phospholipids In Calcium Carbonate Matrix, Krishna Gopal
Doctoral Dissertations
Non-invasive drug delivery systems for therapeutic drugs are gaining prominence. One such system, the nasal delivery system, shows good prospect for effective delivery of some drugs, however, it is yet to be well established for others. The preparation of a reformulated drug and studying its in vitro characteristics is a crucial step in the process of adapting the new drug for nasal delivery systems. The purpose of this research is to study the effect of electrostatic layer by layer assembly of polyelectrolytes on PROMAXX®insulin microparticles and to study the chemical, physical and corresponding release properties of the resulting formulations. PROMAXX® …
Multicomponent Patterning Of Nanocomposite Polymer And Nanoparticle Films Using Photolithography And Layer-By-Layer Self -Assembly, Javeed Shaikh Mohammed
Multicomponent Patterning Of Nanocomposite Polymer And Nanoparticle Films Using Photolithography And Layer-By-Layer Self -Assembly, Javeed Shaikh Mohammed
Doctoral Dissertations
In this dissertation, the fabrication, characterization, and application examples of 3D multicomponent nanocomposite micropatterns (MNMs) with precise spatial arrangements are described. The ability to produce such small-scale 3D structures with versatility in composition and structure is a new development based on the integration of nanoscale layer-by-layer (LbL) self-assembly and microscale photolithographic patterning, enabling construction of surfaces with microscale patterns that possess nanotopographies. The techniques used here are analogous to surface micromachining, except that the deposition materials are polymers, biological materials, and colloidal nanoparticles used to produce 3D MNMs. A key feature of the resulting 3D MNMs is that the physical …