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A Comprehensive Analysis Of The Androgen Receptor Gene And Risk Of Breast Cancer: Results From The National Cancer Institute Breast And Prostate Cancer Cohort Consortium (Bpc3), David G. Cox, Hélène Blanché, Celeste L. Pearce, Eugenia E. Calle, Graham A. Colditz, Malcolm C. Pike, Demetrius Albanes, Naomi E. Allen, Pilar Amiano, Goran Berglund, Heiner Boeing, Julie Buring, Noel Burtt, Federico Canzian, Stephen Chanock, Françoise Clavel-Chapelon, Heather S. Feigelson, Matthew Freedman, Christopher A. Haiman, Susan E. Hankinson, Brian E. Henderson, Robert Hoover, David J. Hunter, Rudolf Kaaks, Laurence Kolonel, Peter Kraft, Loic Lemarchand, Eiliv Lund, Domenico Palli, Petra H.M. Peeters, Elio Riboli, Daniel O. Stram, Michael Thun, Anne Tjonneland, Dimitrios Trichopoulos, Meredith Yeager

Susan E. Hankinson

Introduction: Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/or androgen receptor (AR) in the breast. Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). Methods: The underlying genetic variation was determined by first sequencing the coding regions of the AR gene in a panel of 95 advanced breast cancer cases. Second, …