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Chemotherapeutic Cns Prophylaxis And Neuropsychologic Change In Children With Acute Lymphoblastic Leukemia: A Prospective Study, K. A. Espy, I. M. Moore, P. M. Kaufmann, J. H. Kramer, K. Matthay, J. J. Hutter
Chemotherapeutic Cns Prophylaxis And Neuropsychologic Change In Children With Acute Lymphoblastic Leukemia: A Prospective Study, K. A. Espy, I. M. Moore, P. M. Kaufmann, J. H. Kramer, K. Matthay, J. J. Hutter
Developmental Cognitive Neuroscience Laboratory: Faculty and Staff Publications
OBJECTIVE: To determine whether prophylactic CNS chemotherapy for childhood acute lymphoblastic leukemia is associated with declines in neuropsychological abilities. METHODS: Growth curve analysis was used to examine neuropsychological outcome and treatment-related change in children (N = 30) who were treated at two childhood cancer centers. A comprehensive test battery was administered at baseline (8 months), 2, 3, and 4 years postdiagnosis (age at diagnosis M = 5.90 years, SD = 4.2C). RESULTS: Results indicated modest declines in arithmetic, visual motor integration, and verbal fluency. Intrathecal and systemic treatment was related to poorer visual motor integration at 4 years postdiagnosis and …