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Development Of Methods For The Detection Of Chemical And Biological Warfare Agents, Megan Rea Dejesus
Development Of Methods For The Detection Of Chemical And Biological Warfare Agents, Megan Rea Dejesus
Graduate Theses, Dissertations, and Problem Reports
This dissertation sought to find conditions that enabled the characterization of weapons of mass destruction, be that chemical, explosives, or biological, and find unique ion signals for those materials. Chapter 2 examines how to improve the analytical capability of the pulsed glow discharge through an increased understanding of the ionization processes inherent to the technique. Results of a parametric evaluation of ionization processes in the plasma demonstrated that within the glow discharge ion source there are conditions that can be determined which will enhance the signal of the analytical ion. A key innovation was the determination, that in constant power …
Fate And Transport Of Methamphetamine And Related Compounds In Remediated Clandestine Laboratories, Holly A. Mccall
Fate And Transport Of Methamphetamine And Related Compounds In Remediated Clandestine Laboratories, Holly A. Mccall
Graduate Theses, Dissertations, and Problem Reports
Remediation of clandestine laboratories has become a national concern due to health and environmental concerns. To date, remarkably little has been published regarding the fate and transport of methamphetamine in clandestine laboratories, both before and after remediation. The fate and transport of methamphetamine in an indoor air environment is an inherently complex process, where the drug can move as either particulate matter or vapor. The ability to diffuse throughout a building structure increases the need for analysis techniques that can evaluate potential exposure by various means. This research investigated three analytical methods for the detection of methamphetamine: ion mobility spectrometry …
Reproducibility Of Retention Indices Examining Column Type, Amanda M. Cadau
Reproducibility Of Retention Indices Examining Column Type, Amanda M. Cadau
Graduate Theses, Dissertations, and Problem Reports
Requests for drug analysis accounted for nearly half of all requests (DNA, toxicology, latent prints, etc.) submitted to forensic laboratories in the United States (Storm et al., 2010). A study by RTI International found that laboratories are only capable of processing about 80% of their controlled substances requests. Based upon this statistic, an estimated 220,000 cases per year would be back-logged. Therefore, tools that can improve the process of seized drug analysis would be of use. This project addresses one such concept, the use of retention indices as a means to improve drug screening using gas chromatography/mass spectrometry (GC/MS).;When drugs …
Evaluating The Ability Of Different Weak Acids When Combined With Hydrogen Peroxide To Develop Latent Fingerprints On Post-Fired Cartridge Cases, Casey Nicholas Oleksa
Evaluating The Ability Of Different Weak Acids When Combined With Hydrogen Peroxide To Develop Latent Fingerprints On Post-Fired Cartridge Cases, Casey Nicholas Oleksa
Graduate Theses, Dissertations, and Problem Reports
This study examined the effectiveness of different weak acids in developing fingerprints on different types of cartridge cases when combined with hydrogen peroxide due to a process known as chemical etching. Chemical etching involves an oxidation-reduction in which the metal is oxidized by the acid. Three types of cartridge cases were used: bi-metal, brass, and aluminum. Five different acids of varying pKa were used: acetic, citric, lactic, maleic, and propanoic. Each acid was made up to a different concentration to reflect the same pH as 1.0M H+ ions. Phase I involved testing each acid with each case printed after firing …
De Novo Asymmetric Synthesis Of Biologically Active Carbohydrate Natural Products And Related Sar Studies, Bulan Wu
Graduate Theses, Dissertations, and Problem Reports
The carbohydrate portion of natural products plays an important role in its biological activity, such as solubility, target binding, tissue targeting, and membrane transportation. Over the last fourteen years, Dr. O'Doherty's group has been developing de novo methodologies to build the desired carbohydrate functionality and stereochemistry within each sugar from simple achiral starting materials in stark contrast to the traditional carbohydrate approach using known sugar isomers as starting materials. The methodologies depend on a highly diasteroselective palladium-catalyzed glycosylation reaction to control the anomeric stereochemistry, and a highly enantioselective Noyori reduction to install the sugar absolute stereochemistry. Appropriate post-glycosylation transformations create …
Comprehensive Analysis Of Gamma-Hydroxybutyrate And Gamma-Hydroxyvalerate, Jennifer Wiseman Mercer
Comprehensive Analysis Of Gamma-Hydroxybutyrate And Gamma-Hydroxyvalerate, Jennifer Wiseman Mercer
Graduate Theses, Dissertations, and Problem Reports
gamma-Hydroxybutyrate (GHB) and gamma-hydroxyvalerate (GHV) are suspected agents of drug facilitated sexual assault. Research is needed to improve detection methods for both drugs for a range of instrumentation commonly available to forensic chemists. GHB evidence may be introduced to the laboratory in the form of a powder, solution, beverage, or biological sample; thus a key theme of this research is overcoming matrix effects for comprehensive analyses. As GHV is not commercially available, it was synthesized for analysis via base hydrolysis of gamma-valerolactone (GVL). The results of the synthesis were confirmed using infrared (IR) spectroscopy and proton nuclear magnetic resonance (H1NMR) …
A New Reduced Order Model For Solid Oxide Fuel Cells, Suryanarayana Raju Pakalapati
A New Reduced Order Model For Solid Oxide Fuel Cells, Suryanarayana Raju Pakalapati
Graduate Theses, Dissertations, and Problem Reports
Fuel cells are one of the promising eco-friendly and efficient electricity generators for future energy infrastructure. Rigorous research has been underway for over a decade to develop fuel cell technology as a viable alternative to the conventional energy sources. Numerical modeling has played a prominent role in such research endeavors. Detailed multi-dimensional models reveal important information regarding the performance of a fuel cell but they are computationally intensive. Relatively simple zero- and one-dimensional models on the other hand average out the details that could be critical. The topic of this dissertation is a new strategy for modeling fuel cells which …