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Design And Synthesis Of Beta-Hairpin Peptidomimetics For Modulating Integrin Mediated Cell Adhesion, Abeta Fibrillogenesis And P53-Mdm2 Protein-Protein Interactions, Priyesh Jain

USF Tampa Graduate Theses and Dissertations

Inhibiting therapeutically important protein-protein interactions has been a tremendous challenge for medicinal chemists. The folded 3D structures of peptides and proteins, mainly comprise secondary structural elements i.e α-helices and β-sheet have created an opportunity to design small molecules and peptidomimetic inhibitors of protein-protein interaction (PPI). Hence, information about the formation and stabilization of these secondary structures is vital for designing future drugs. In this dissertation, several cyclic beta-hairpin peptidomimetics that mimic the recognition surface have been designed and synthesized as inhibitors for different targets such as integrin mediated extracellular matrix -cell adhesion in multiple myeloma, p53-MDM2 PPI, amyloid beta fibrillogenesis …

Advanced Signal Processing Techniques For Single Trial Electroencephalography Signal Classification For Brain Computer Interface Applications, Kun Li

USF Tampa Graduate Theses and Dissertations

Brain Computer Interface (BCI) is a direct communication channel between brain and computer. It allows the users to control the environment without the need to control muscle activity [1-2]. P300-Speller is a well known and widely used BCI system that was developed by Farwell and Donchin in 1988 [3]. The accuracy level of the P300-BCI Speller as measured by the percent of communicated characters correctly identified by the system depends on the ability to detect the P300 event related potential (ERP) component among the ongoing electroencephalography (EEG) signal. Different techniques have been tested to reduce the number of trials needed …

A Framework For Determining The Reliability Of Nanoscale Metallic Oxide Semiconductor (Mos) Devices, Wilkistar Otieno

USF Tampa Graduate Theses and Dissertations

An increase in worldwide investments during the past several decades has pro-pelled scienti c breakthroughs in nanoscience and technology research to new and exciting levels. To ensure that these discoveries lead to commercially viable prod-ucts, it is important to address some of the fundamental engineering and scientific challenges related to nanodevices. Due to the centrality of reliability to product integrity, nanoreliability requires critical analysis and understanding to ensure long-term sustainability of nanodevices and systems. In this study, we construct a relia-bility framework for nanoscale dielectric lms used in Metallic Oxide Semiconductor (MOS) devices. The successful fabrication and incorporation of metallic …

Dna Methylation And Its Association With Prenatal Exposures And Pregnancy Outcomes, Jennifer Straughen

USF Tampa Graduate Theses and Dissertations

Altered DNA methylation may lead to suboptimal fetal programming, increasing the risk of adverse pregnancy outcomes such as small for gestational age (SGA); however, few studies have examined the associations between DNA methylation, prenatal exposures, and fetal outcomes. Cross-sectional data from a larger, ongoing study were used to assess the impact of prenatal smoking on gene specific methylation of umbilical cord blood derived DNA and to investigate the association between gene-specific methylation and risk of SGA. The association between gene-specific DNA methylation and birthweight was also assessed. Maternal and infant covariates were abstracted from medical records, cigarette smoke exposure was …

Evaluation Of Common Inherited Variants In Mitochondrial-Related And Microrna-Related Genes As Novel Risk Factors For Ovarian Cancer, Jennifer Permuth Wey

USF Tampa Graduate Theses and Dissertations

Epithelial ovarian cancer (EOC) is a leading cause of morbidity and mortality among women in the United States, and the etiology is incompletely understood. Common, low penetrant genetic variants such as single nucleotide polymorphisms (SNPs) likely contribute to a significant proportion of EOC. We examined whether SNPs in two understudied yet biologically important types of genes, mitochondrial-related and miRNA-related genes, may contribute to EOC susceptibility using data from a large, homogeneous study population of 1,815 EOC cases and 1,900 controls (frequency-matched on age-group and race/ethnicity) genotyped through stage 1 of an ongoing genome-wide association study. Inter-individual variation in genes involved …

Epidemiological Study Of Contributing Factors In The Development Of Peptic Ulcer And Gastric Cancer Initiated By Helicobacter Pylori Infection In India, Rahul Suresh Mhaskar

USF Tampa Graduate Theses and Dissertations

Background: Helicobacter pylori (H. pylori) infection is a significant risk factor for peptic ulcer (PU) and gastric cancer (GC). Apart from the virulent CagA genotype of H. pylori environmental and dietary factors influence disease outcomes. There have been no studies addressing these factors in Western India. Hence, we conducted a case control study enrolling PU, GC patients and controls at Pune, India.

Methods: Risk factors for PU and H. pylori infection were assessed in participant interview. H. pylori status was assessed from stool by monoclonal antigen detection. To understand treatment effect, we followed 100 H. pylori positive patients.

Results: We …

Corrole Synthesis And Catalytic Applications Toward Cobalt(Iii)-Catalyzed Epoxidation, N-H Insertion, And Cyclopropanation, Chung Sik Kim

USF Tampa Graduate Theses and Dissertations

A variety of bromocorroles, useful precusors for Pd-based cross coupling, were sucessfully synthesized in moderate to good yields. Chiral corroles were also synthesized through use of chiral amides in the aforementioned cross coupling reactions. Cobalt complexes bearing π-acceptor (CNtBu) and σ-donor (PPh3) ligands were also prepared in excellent yields. In this dissertation, cobalt (III) corrole complexes were applied to three different reaction areas: epoxidation, N-H insertion, and cyclopropanation. Cobalt(III) corroles were found to be efficient catalysts for epoxidation reactions. The epoxidation reactions can be carried out using ethyl phenyldiazoacetate, an acceptor/donor diazo compound, as a carbenoid precusor.The reaction provided highly …

Florida's Adolescent Literacy Policy: An Alternative Reading And Response, Diane Kroeger

USF Tampa Graduate Theses and Dissertations

In this qualitative case study, I constructed interpretations of the meanings conveyed by state-level discourse communities as they were manifested in the primary and secondary speech genres of Florida’s adolescent literacy policy. Meanings (or values, beliefs and feelings) are highly tacit understandings embedded in the language, actions and objects of policy (Yanow, 2000), and are conveyed through informal and formal speech (Bakhtin, 1986). Results revealed (a) state policy meanings convey multiple versions of literacy with a heavy focus on receptive aspects of literate practice; (b) a typology of students and their fit within the institutional system; and (c) an emphasis …

Aspects Of The Life History Of The Snowy Grouper, Epinephelus Niveatus, In The Gulf Of Mexico, Kelley Kowal

USF Tampa Graduate Theses and Dissertations

Knowledge of many life history parameters are essential to properly assess and manage fish species. Although the snowy grouper, Epinephelus niveatus, is a commercially valuable fish, which is harvested throughout the Gulf of Mexico, little is known about its age, growth, and reproduction from this region. In this study, snowy grouper from the northern and eastern regions of the Gulf of Mexico were examined primarily using commercially-derived samples that were collected between 1984 and 2004. A total of 1,200 snowy grouper with fork lengths between 242 and 1,190 mm were collected. Sectioned saggital otoliths were used to determine the age …

Discovery Of Novel Viruses From Animals, Plants, And Insect Vectors Using Viral Metagenomics, Terry Fei Fan Ng

USF Tampa Graduate Theses and Dissertations

Understanding emerging viruses is critical for disease monitoring and prediction; however, surveys of novel viruses are hindered by the lack of a universal assay for viruses. Viral metagenomics, consisting of viral particle purification and shotgun sequencing, is a powerful technique for discovering viruses in a wide variety of sample types. However, current protocols are not effective on tissue samples (e.g., lungs, livers and tumors), where they are hindered by the high amount of host nucleic acids which limits the percentage of sequences that originate from viruses. In this dissertation, a modified viral metagenomics protocol was developed and utilized to effectively …

Antecedents And Consequences Of Channel Alienation: An Empirical Investigation Within Franchised Channels Of Distribution, Ivan Lapuka

USF Tampa Graduate Theses and Dissertations

Investigating an important overlooked phase of interorganizational relationship evolution, which is currently hypothesized to progress through five stages of awareness, exploration, expansion, commitment, and dissolution, this dissertation proposes that in the long road between commitment and dissolution, the quintessential interfirm relationship is likely to be characterized by aprolonged period of relationship alienation, which then becomes the immediate precursor to the dissolution stage.

The dissertation utilizes social learning theory, behavior constraint theory, and alienation theory to explain apathetic behaviors of franchisees. The principal proposition is that certain characteristics of the franchise system’s operating environment inadvertently condition franchisee estrangement and failure, and …

Down, But Not Out: An Ethnographic Study Of Women Who Struggled With And Overcame Methamphetamine Addiction, Jodi Nettleton

USF Tampa Graduate Theses and Dissertations

Women suffer methamphetamine (meth) addiction at a rate much higher than rates for addiction to other drugs. Female meth users are susceptible and predisposed to gender-related risks: high rates of unprotected vaginal and anal sex, sex-work, and sexual coercion. Precursors for addiction (e.g., abuse, body dysphasia) put females in a difficult position for recovery and highlight the need for gender-specific research and treatment.

Methamphetamine (a synthetically derived stimulant) creates psychological and physical dependency that affects every neuron of the brain and damages the body immediately. Women ingest meth for initial effects that allay social pressures: feeling euphoric, connecting with others …

African American Athletes And The Negotiation Of Public Spaces: An Examination Of Athletic Capital And African American Perceptions Of Success, Keona Lewis

USF Tampa Graduate Theses and Dissertations

This dissertation explores the culture of sport among African American male football players as well as African American perspectives on sport and success. A case study of six African American, Division 1 FBS (Football Bowl Subdivision) collegiate student athletes was conducted along with seventeen supplemental interviews with community members, parents, coaches and former athletes and fans. The participants answered questions that explored education, success, identity construction, ethnicity and sport. Archival data was also reviewed framing the discussion on football in Florida, links between education and sport participation and African American male academic achievement. While many perspectives varied, there were collective …

Comparison Of Safety Performance By Design Types At Freeway Diverge Areas And Exit Ramp Sections, Hongyun Chen

USF Tampa Graduate Theses and Dissertations

The primary objective of the study is to evaluate the safety performance of different freeway exit types used in current practical designs. More specific, the research objectives include the following two parts: 1) to compare the safety performance of different design types at freeway diverge areas and exit ramp sections; and 2) to identify the impact factors contributing to the crashes happening at these two specific segments.

The study area includes four subjects, the freeway widely-spaced diverge areas; the freeway closely-spaced diverge areas; the left-side off-ramps and the exit ramp sections. For the freeway diverge areas, design types were defined …

Of Music, Mathematics, And Magic: Why Math Is All Made Up And Why It Works So Well, Gregory A. Leach

Masters Theses

No abstract provided.

Near Minimum Energy Distributions On The Sphere Using Voronoi Cells, Benedictus Sitou Mensah

Masters Theses

No abstract provided.

Connecting Children And Families: Expectations And Experiences Of Professional Foster Parents, Samantha A. Goodrich

Master's Theses

No abstract provided.

A Multicriteria Based Quantitative Framework For Assessing Sustainability Of Pile Foundations, Aditi Misra

Master's Theses

ABSTRACT

Civil Engineering is the major instrument of anthropocentric development over centuries through ever expanding infrastructure, cities and facilities. Civil engineering processes are both resource and fuel intensive. The building industry alone, during the construction stage, uses about 30-40% of the total resources used in the industrialized countries. There is a growing consensus that delivering a sustainable built environment starts with incorporating sustainability thoughts at the planning and design stages of a project. Geotechnical engineering is most resource intensive although this intensive consumption of energy goes unnoticed mainly because of the indirect nature of the energy used in the …

The Potential Relationship Between The Traits Associated With Left Brain Or Right Brain Dominant Tendencies And The Characteristics Of Leaders Or Managers, Alex Keto

Theses and Graduate Projects

The debate over whether the characteristics of leadership and management are unique characteristics or whether they are one-in-the-same characteristics continues today. In the past, traditionally, the best managers within a company were promoted to roles of leadership and many times these new leaders failed. There is growing support for the concept that the characteristics of highly effective leaders and managers are unique. A review of these characteristics reveals a potential relationship between the characteristics of exceptional managers and the traits that have been associated with left brain dominant tendencies. The characteristics of exceptional leaders relate to the traits that have …

Strategies To Resolve The Three-Dimensional Structure Of The Genome Of Small Single-Stranded Icosahedral Viruses, Eduardo Sanz Garcia

Theses and Dissertations

The aim of this study is the three-dimensional structural characterization of the genome packaging inside viral capsids via cryo-electron microscopy and three-dimensional reconstruction. The genome of some single-stranded viruses can be densely packaged within their capsid shells. Several stretches of the genome are known to adopt stable secondary structures, however, to date, little is known about the three-dimensional organization of the genome inside their capsid shells. Two techniques have been developed to facilitate the structural elucidation of genome packaging: the asymmetric random-model method, and the symmetry-mismatch, random model method. Both techniques were successfully tested with model and experimental data. The …

Dustbowl, Patrick Scott Harned

Theses

Dustbowl is a dystopian novel that follows a young man named Ward as he joins a deadly cult that is intent on leaving the planet. He travels with a cleaning crew—a group of killers—through small towns, abducting children for the cult’s plan to have humankind populate the stars. The novel explores concepts like loneliness, grief, violence, love, and family, among others, as Ward traverses across a dust-filled, shambling American Midwest that is falling apart all around him. He finds solace from the harshness of the world in his crewmates, in a stray dog that he happens upon, in a girl …

Family Conversations About Stressful Life Experiences, Genevieve Lee Davis

Electronic Theses and Dissertations

The present study was designed to investigate whether family conversations moderated the relation between stressful life experiences in childhood and negative emotion-related outcomes in young adulthood. Undergraduate students (N = 99, mean age = 19.6 years, 77% females) were administered a semi-structured interview about their childhood stressful life experiences and use of family conversations in response to those experiences. They also completed questionnaires about their current levels of depression, eating-related difficulties, self-harm behaviors, and aggression. It was found that talking with one's parent moderated the relation between number of stressful life experiences and history of self-harm behaviors. Additionally, the participants' …

Air-Sea Turbulent Flux Measurements And Their Relationship To The Turbulent Kinetic Energy Dissipation Rate In The Ocean, Silvia Gremes-Cordero

Open Access Dissertations

A study of the turbulent transfer of properties across the ocean surface and the dissipation of the energy transferred to the upper ocean is here presented. Two experiments were analyzed, both conducted during summer in the North Atlantic during phytoplankton blooms. The Marine Aerosol Production from marine sources (MAP) experiment, performed during summer of 2004, allowed for the calculation of the air-sea turbulent fluxes of momentum and humidity in high wind conditions. This analysis aims to improve the parameterization of air-sea turbulent fluxes, fundamental for coupled atmospheric-ocean models. In particular, there are very few previous calculations of the bulk coefficients …

Environmental Consciousness: Human Motivation For Thinking Ecologically, Rob Pigue

Student Theses 2001-2013

What is the motivation for acting environmentally? Why do people care? What is the reason for buying fluorescent bulbs and hybrid cars, energy efficient appliances and reusable water bottles? Why is it that people turn off the lights when they leave a room, turn off the faucet while brushing their teeth, and go through the inconvenience of recycling?

Humans are known to act out of self-interest. Regardless of what people do or why they do it, their motivation can always be traced back to personal gain.

So why go green? Nothing about reducing, reusing, or recycling has any direct impact …

Study On Algebras With Retractions And Planes Over A Dvr., Prosenjit Das Dr.

Doctoral Theses

Aim:The main aim of this thesis is to study the following problems:1. For a Noetherian ring R, to find a set of minimal sufficient fibre conditions for an R-algebra with a retraction to R to be an A1-fibration over R.2. To investigate sufficient conditions for a factorial A1-form, with a retraction to the base ring, to be A1.3. To investigate whether planes of the form b(X, Y)Zn – a(X, Y) are co- ordinate planes in the polynomial ring in three variables X, Y and Z over a discrete valuation ring.The 1st problem will be discussed in Chapter 3 entitled Codimension- …

Haunting Witnesses: Diasporic Consciousness In African American And Caribbean Writing, Brandi Bingham Kellett

Open Access Dissertations

This project examines the ways in which several texts written in the late twentieth century by African American and Caribbean writers appropriate history and witness trauma. I read the representational practices of Toni Morrison, Ernest Gaines, Paule Marshall, and Fred D'Aguiar as they offer distinct approaches to history and the resulting effects such reconstituted, discovered, or, in some cases, imagined histories can have on the affirmation of the self as a subject. I draw my theoretical framework from the spaces of intersection between diaspora and postcolonial theories, enabling me to explore the values of the African diaspora cross-culturally as manifested …

Formalizing A Conceptual Framework Of Work Domain Knowledge, Min Zhu

Dissertations & Theses (Open Access)

Background: The failure rate of health information systems is high, partially due to fragmented, incomplete, or incorrect identification and description of specific and critical domain requirements. In order to systematically transform the requirements of work into real information system, an explicit conceptual framework is essential to summarize the work requirements and guide system design. Recently, Butler, Zhang, and colleagues proposed a conceptual framework called Work Domain Ontology (WDO) to formally represent users’ work. This WDO approach has been successfully demonstrated in a real world design project on aircraft scheduling. However, as a top level conceptual framework, this WDO has not …

Feasibility Study Among Military Personnel With Traumatic Amputation During Military Combat Or Training, Michele (Shelly) R. Burdette-Taylor Phd, Msn, Rn-Bc, Cwcn, Cfcn

Dissertations

Military operations have resulted in a significant number of mangled extremities leading to traumatic amputations. Extremity injuries predominate, representing 50% to 70% of all injuries treated (Melcer, 2010). The majority of injuries sustained in Operation Endearing Freedom/Operation Iraqi Freedom (OEF/OIF) are combined penetrating, burn and blast injuries, traumatic amputation, and infections from the multi-drug resistant organism, Acinetobacter (Melcer, 2010). The purpose of this study was to measure the quality of well-being and impact of events in a group of adults who served in the U.S. armed forces and sustained the loss of one or more limbs during any combat or …

Theatre Of The Arts: Caribbean Intertextuality And The Muse Of Place, Lara B. Cahill-Booth

Open Access Dissertations

Theatre of the Arts: Caribbean Intertextuality and the Muse of Place is a literary geography that explores how specific environments shape imaginative interventions into history and language. I begin by examining the unity of Derek Walcott's vision of the sea, tracing its ties to oral history, literary canon, and personal reveries of emplacement in Omeros and other epic-minded poems. I follow the sea to its continental origins, examining the Guyanas, an Amazonian bioregion on the borderlands of Guyana, Brazil, and Venezuela, as a place imaginatively remapped by twentieth-century novelists Alejo Carpentier, Wilson Harris, Mario de Andrade, and Pauline Melville. I …

A Comparative Analysis Of Changes In Postural Control Following Training Using The Wii Balance Program And Standardized Falls Prevention Programs, Alessandra Pluchino

Open Access Dissertations

Declines in balance and postural control are believed to be the major neuromuscular factors that contribute to an increased risk of falling with age. Balance training has been reported to be an effective tool for increasing these parameters in older fallers, but its effectiveness in improving balance in higher-functioning, independent-living elders is uncertain. PURPOSE: The purpose of this study was to compare the impact of two formal balance-training interventions (Tai Chi and standardize balance exercise program [SBEP]) and an activity-promoting video game, the Wii Fit balance program. METHODS: Twenty-nine healthy, independent seniors (72.10 ± 7.80) were randomly assigned to eight …