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Catalytic Aziridination With A Borate-Containing N-Heterocyclic Tetracarbene Iron Complex, Preeti Pradip Chandrachud

Doctoral Dissertations

Aziridines, the nitrogen analog of epoxides, are an important class of compounds. They are present in many biologically active compounds having antibacterial and antitumor properties. Along with biological significance, it can also be considered as a synthetic tool for various functional group transformations. Being an important functional group we focused on the development of synthetic methodology using alkenes as substrates and organic azides as the nitrene source [C₂ (carbon2)+ N₁ (nitrogen1) addition reaction].

For the potential use as an aziridination catalyst a macrocyclic N-heterocyclic tetracarbene (NHC) ligand system was developed. First, the neutral NHC ligand was used …