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Exploring Novel Anti-Obesity Strategies: Nutritional And Pharmacological Interventions To Induce Browning And Brown Adipogenesis, Haley Beth Overby
Exploring Novel Anti-Obesity Strategies: Nutritional And Pharmacological Interventions To Induce Browning And Brown Adipogenesis, Haley Beth Overby
Doctoral Dissertations
Obesity is a global pandemic and its comorbidities are the top causes of preventable death in America. Brown and inducible beige fat can significantly contribute to energy expenditure, possibly leading to weight loss, and is considered a novel approach to combat obesity. Browning of white adipocytes can be achieved using cold exposure, β [beta]-adrenergic receptor (β-AR) and peroxisome proliferator-activated receptor gamma (PPAR [gamma]) agonists, and some nutritional and pharmaceutical agents. Trans-resveratrol (Res) and indomethacin (Indo) have shown promising abilities to promote browning. Res has been shown to induce browning in vitro and in vivo; however, its rapid metabolism and poor …
Observation Of Baryon Number Violation Via Cold Neutron Sources, Matthew Frost
Observation Of Baryon Number Violation Via Cold Neutron Sources, Matthew Frost
Doctoral Dissertations
The observation of neutron/anti-neutron transformation would directly, and for the first time, demonstrate that there are processes that violate baryon number, thus revealing the fundamental mechanism of the origin of our universe. Prior experiments that would show the existence of such transformations are inconclusive thus far, providing only lower limits for the transformation rate. New experiments utilizing cold neutrons at spallation sources such as the European Spallation Source (ESS) provide a means by which to search for these higher energy scale phenomena beyond that which can be achieved with a collider. An experiment with the opportunity to contribute to the …
Nanobrazing Of Inconel 718 And Ti-6al-4v, Denzel Bridges
Nanobrazing Of Inconel 718 And Ti-6al-4v, Denzel Bridges
Doctoral Dissertations
For high temperature brazing applications, several design considerations must be evaluated including metallurgical compatibility, mechanical stability, wettability, and many others. One of the obstacles to high temperature brazing is minimizing the melting temperature of the brazing material without sacrificing high operating temperature. Traditionally, this is accomplished by adding melting point depressants such as boron and silicon. However, the addition of boron and silicon exposes the base material to the formation of brittle boride and silicide intermetallic phases and/or low melting eutectic phases. Nanomaterials experience size-dependent melting point depression without the use of melting point depressants via the Gibbs-Thomson effect. Until …
Synthesis And Application Of Oil-Soluble Polymer Brush-Grafted Silica Nanoparticles As Lubricant Additives For Friction And Wear Reduction, Bryan Thomas Seymour
Synthesis And Application Of Oil-Soluble Polymer Brush-Grafted Silica Nanoparticles As Lubricant Additives For Friction And Wear Reduction, Bryan Thomas Seymour
Doctoral Dissertations
Although inorganic and metallic nanoparticles are potentially effective oil lubricant additives for friction and wear reduction, their high tendency to undergo aggregation and precipitation in base oils has been an obstacle for real-world applications. This dissertation research aims to develop oil-soluble, polymer brush-grafted nanoparticles (hairy NPs) for use as additives for base oils such as polyalphaolefin (PAO). Well-defined hairy NPs were synthesized by surface-initiated reversible addition-fragmentation chain transfer polymerization from chain transfer agent-functionalized, 23 nm silica NPs, and their lubrication properties were investigated in PAO by high-contact-stress ball-on-flat reciprocating sliding tribological tests.The effects of alkyl pendant groups of poly(alkyl methacrylate) …