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Automated Intelligent Cueing Device To Improve Ambient Gait Behaviors For Patients With Parkinson's Disease, Nader Naghavi
Automated Intelligent Cueing Device To Improve Ambient Gait Behaviors For Patients With Parkinson's Disease, Nader Naghavi
Doctoral Dissertations
Freezing of gait (FoG) is a common motor dysfunction in individuals with Parkinson’s disease (PD). FoG impairs walking and is associated with increased fall risk. Although pharmacological treatments have shown promise during ON-medication periods, FoG remains difficult to treat during medication OFF state and in advanced stages of the disease. External cueing therapy in the forms of visual, auditory, and vibrotactile, has been effective in treating gait deviations. Intelligent (or on-demand) cueing devices are novel systems that analyze gait patterns in real-time and activate cues only at moments when specific gait alterations are detected. In this study we developed methods …
Effect Of Ambient Oxidation On Chemical Composition And Structural Properties Of Iron Nanoparticles For Hyperthermia And Medical Imaging, Adam Wesley Evans
Effect Of Ambient Oxidation On Chemical Composition And Structural Properties Of Iron Nanoparticles For Hyperthermia And Medical Imaging, Adam Wesley Evans
Doctoral Dissertations
With magnetization saturation roughly twice that of iron oxide nanoparticles, metallic iron nanoparticles (also termed zero-valent iron nanoparticles) have desirable properties for use as a magnetic resonance imagining (MRI) contrast agent as well as a medium for hyperthermia treatment of cancer. Metallic iron nanoparticles, however, are difficult to synthesize and maintain due to their high degree of reactivity and proclivity for oxidation. The main goal of this study was to investigate how ambient oxidation affects the chemical composition and structural properties of metallic iron nanoparticles initially synthesized through a facile reduction reaction of iron (III) chloride with sodium borohydride. A …
Phylogenetics And Association Analyses Illustrate Substantial Cryptic Diversity Of A Newly Isolated Collection Of Cenococcum Geophilum, Jessica Velez
Phylogenetics And Association Analyses Illustrate Substantial Cryptic Diversity Of A Newly Isolated Collection Of Cenococcum Geophilum, Jessica Velez
Doctoral Dissertations
The ectomycorrhizal fungus Cenococcum geophilum is distributed worldwide across multiple climates and soil types and is known to positively associate with a multitude of plant genera, possibly contributing to plant ability to tolerate inorganic contaminants in a soil environment. New C. geophilum isolates are easily cultured from soils in a laboratory setting, making this an ideal candidate for a model species with which to study multiple plant-fungal effects across a collection of novel isolates. However, C. geophilum is also genetically complex and, at 178Mbp, features one of the largest fungal genomes, necessitating the use of the novel restriction-associated DNA sequencing …
Analysis And Enhancement Of Human Cognitive Control Using Noninvasive Brain-Computer Interfaces, Soheil Borhani
Analysis And Enhancement Of Human Cognitive Control Using Noninvasive Brain-Computer Interfaces, Soheil Borhani
Doctoral Dissertations
Cognitive control including attention and working memory are crucial to human daily life. Whether a civilian who walks across a street or a military service member who is responsible for navigating a mission, cognitive control is involved, entirely. This ability is subject to impairment. People with attention disorder are easily disposed to distraction and lacks the ability to maintain the focus to a task. Multiple treatment strategies have been suggested which most of them has been pharmaceutical. Evidently, the medical treatment has side effects for long-term use. Moreover, it has a risk of drug misuse. Another line of treatment is …
Engineering Platforms For Advancing Plant Synthetic Biology, Tayler Marie Schimel Mcneillie
Engineering Platforms For Advancing Plant Synthetic Biology, Tayler Marie Schimel Mcneillie
Doctoral Dissertations
This work describes research aimed at adapting advanced engineering systems for plant biotechnology. The droplet interface bilayer (DIB) is a robust and versatile platform for replicating model cell membranes, providing a bottom-up approach for synthetic cell- and tissue-like structures. In this work, a microfluidic device featuring five inlets, one for the continuous oil phase and four discrete aqueous channels for droplet generation was designed. Droplet production rates were controlled by adjusting the applied pressure of each inlet; and thus, altering the droplet sequence for capturing linear DIB networks in a downstream hydrodynamic trapping array. This microfluidic system provides a high-throughput …
Approaches To Studying Bacterial Biofilms In The Bioeconomy With Nanofabrication Techniques And Engineered Platforms., Michelle Caroline Halsted
Approaches To Studying Bacterial Biofilms In The Bioeconomy With Nanofabrication Techniques And Engineered Platforms., Michelle Caroline Halsted
Doctoral Dissertations
Studies that estimate more than 90% of bacteria subsist in a biofilm state to survive environmental stressors. These biofilms persist on man-made and natural surfaces, and examples of the rich biofilm diversity extends from the roots of bioenergy crops to electroactive biofilms in bioelectrochemical reactors. Efforts to optimize microbial systems in the bioeconomy will benefit from an improved fundamental understanding of bacterial biofilms. An understanding of these microbial systems shows promise to increase crop yields with precision agriculture (e.g. biosynthetic fertilizer, microbial pesticides, and soil remediation) and increase commodity production yields in bioreactors. Yet conventional laboratory methods investigate these micron-scale …