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The Role Of T-Cell Lymphoma Invasion And Metastasis 2 (Tiam2) In The Barrier Function Of Mammary Epithelial Cells Following Streptococcus Uberis Inoculation, Catherine E. Donnell
The Role Of T-Cell Lymphoma Invasion And Metastasis 2 (Tiam2) In The Barrier Function Of Mammary Epithelial Cells Following Streptococcus Uberis Inoculation, Catherine E. Donnell
Chancellor’s Honors Program Projects
No abstract provided.
Identifying Genome Associations With Unique Mastitis Phenotypes In Response To Intramammary Streptococcus Uberis Challenge, Lydia Jean Siebert
Identifying Genome Associations With Unique Mastitis Phenotypes In Response To Intramammary Streptococcus Uberis Challenge, Lydia Jean Siebert
Doctoral Dissertations
Mastitis, the inflammation of the mammary gland, dramatically decreases dairy industry revenues and milk quality, making improved control and prevention methods a goal of the industry. Prior research has observed variation in response to experimental challenge with regards to inflammation indicators, S. uberis concentrations, and the need for antibiotics. To determine possible causes of the observed variation following experimental S. uberis intramammary challenge, we performed genome association analyses (N = 34 – 36 Holstein dairy cows), a linkage analysis, and S. uberis milk inoculation (N = 21 Holstein dairy cows) trials. Association analyses were done using Illumina’s BovineSNP50 BeadChip and …
Identifying Genetic Factors In Streptococcus Uberis That Enable Evasion Of The Host Immune Response, Alexis Christine Burnham
Identifying Genetic Factors In Streptococcus Uberis That Enable Evasion Of The Host Immune Response, Alexis Christine Burnham
Chancellor’s Honors Program Projects
No abstract provided.
Genetic Resistance To Staphylococcus Aureus Mastitis Associated With Bovine Cxcr1, Olivia Jean Crisp
Genetic Resistance To Staphylococcus Aureus Mastitis Associated With Bovine Cxcr1, Olivia Jean Crisp
Chancellor’s Honors Program Projects
No abstract provided.
Bovine Mammary Interleukin-8 Receptor Expression And Genetic Association With Streptococcus Uberis Based Mastitis., Lydia Jean Siebert
Bovine Mammary Interleukin-8 Receptor Expression And Genetic Association With Streptococcus Uberis Based Mastitis., Lydia Jean Siebert
Masters Theses
Mastitis is an economically distressing disease in the dairy industry. Bacterial pathogens enter the gland and encounter cell types that release immune mediators including interleukin (IL)-8. IL-8 has two membrane bound receptors: CXCR1 and CXCR2. CXCR1 and CXCR2 are expressed on neutrophils and other cell types in other species but their expression is unknown in the bovine mammary gland. To test this, mammary tissue samples from six Holstein dairy cows were subject to dual immunofluorescence with bovine specific CXCR1 and CXCR2 antibodies and cell type markers. CXCR1 was expressed on alveolar epithelial cells, fibroblasts, and leukocytes. CXCR2 expression was identified …
Identifying Mechanisms Associated With Innate Immunity In Cows Genetically Susceptible To Mastitis, Alexandra Alida Elliott
Identifying Mechanisms Associated With Innate Immunity In Cows Genetically Susceptible To Mastitis, Alexandra Alida Elliott
Doctoral Dissertations
Mastitis, or mammary gland inflammation, causes the greatest loss in profit for dairy producers. Mastitis susceptibility differs among cows due to environmental, physiological, and genetic factors. Prior research identified a genetic marker in a chemokine receptor, CXCR1, associated with mastitis susceptibility and decreased neutrophil migration. Current research seeks to identify reasons behind mastitis susceptibility by validating this model through in vivo challenge with Streptococcus uberis and studying specific mechanisms causing impaired neutrophil migration. Holstein cows with GG (n=19), GC (n=28), and CC (n=20) genotypes at CXCR1+777 were challenged intramammarily with S. uberis strain UT888. After challenge 68% of quarters from …