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Identification And Cloning Of Transcripts From Triterpenoid-Induced Neuronal Outgrowth In Neuro-2a Cells From Mus Musculus, Meshael Alrashidi Jan 2022

Identification And Cloning Of Transcripts From Triterpenoid-Induced Neuronal Outgrowth In Neuro-2a Cells From Mus Musculus, Meshael Alrashidi

Masters Theses

Neurodegenerative diseases severely reduce quality of life and are often responsible for the death of those suffering from them. In addition to the societal toll these diseases inflict on populations, the health care costs are estimated to be hundreds of billions of dollars annually for the U.S. alone. Unfortunately, direct pharmacological treatment for some of the most common of these diseases, such as Alzheimer’s, remains elusive. Traditional medicine in China and India have recommended a variety of plants for preventing and treating these diseases. For example, Centella asiatica (L.) Urban, also knows as Gotu Kola, is believed to treat and …


The Gene Expression Patterns Of Phanerochaete Chrysosporium And Trametes Versicolor On Diverse Lignocellulosic Feedstocks, Noor Osama Alabbasi Jan 2021

The Gene Expression Patterns Of Phanerochaete Chrysosporium And Trametes Versicolor On Diverse Lignocellulosic Feedstocks, Noor Osama Alabbasi

Masters Theses

Plant biomass is considered to be an important future starting material for fuels and chemicals, thereby decreasing our reliance on fossil fuels. While direct combustion continues to be a source of fuel, the generation of liquid fuels from plant biomass for transportation has proven to be challenging. Among the limiting factors for conversion of this material to biofuels is the recalcitrant nature of lignocellulose, the primary component of non-starch plant biomass. A strategy to overcome this dilemma is to directly or indirectly use the enzymes from white-rot fungi, which have evolved a unique ability to deconstruct lignocellulose. However, the biochemical …


The Transcriptome Response Of The White-Rot Fungus Trametes Versicolor To Wild-Type And Lignin-Modified Hybrid Poplar, Anbarah Alzabaidi Jan 2020

The Transcriptome Response Of The White-Rot Fungus Trametes Versicolor To Wild-Type And Lignin-Modified Hybrid Poplar, Anbarah Alzabaidi

Masters Theses

Plant biomass is a renewable and sustainable feedstock for biofuel production that can reduce societal dependence on fossil fuels. However, the production of liquid biofuels from the non-starch (i.e. lignocellulosic) material through fermentation technology is limited due to the complexity of the cell wall structure. This necessitates the use of chemical, thermal, and/or mechanical pretreatment technologies, which adds significant capital, operational, and environmental costs. Biological pretreatment strategies have the potential to mitigate these expenses by harnessing the innate ability of specialized bacteria and fungi to deconstruct lignocellulose. White-rot fungi (e.g. Trametes versicolor) have been shown to be …


Transcriptome Analysis Of Neuro-2a Cells Treated With Asiatic And Madecassic Acid, Fatimah M. Alqam Jan 2020

Transcriptome Analysis Of Neuro-2a Cells Treated With Asiatic And Madecassic Acid, Fatimah M. Alqam

Masters Theses

Traditional herbal medicine is ingrained as a source of therapeutic compounds to medicate various diseases. The family Araliaceae (Ginseng family) is rich in traditional medicine species, such as Centella asiatica (CA). For many centuries, CA has been used by the indigenous Indian and Chinese in Ayurvedic and traditional medicine, respectively, to improve intelligence, learning, memory, and cognitive performance. Previous studies on cell culture and animal models supported the beneficial effects of CA on the nervous system. However, the exact composition of CA extract and its molecular mechanism that leads to neuroprotection is still unclear. We examined the effect of asiatic …