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A Comparative Study Of Larval Gene Expression Between A Paedomorphic And Metamorphic Species Of Ambystomatid Salamander, Meredith A. Boley
A Comparative Study Of Larval Gene Expression Between A Paedomorphic And Metamorphic Species Of Ambystomatid Salamander, Meredith A. Boley
University of Kentucky Master's Theses
Ambystoma tigrinum undergoes an obligatory metamorphosis while A. mexicanum fails to metamorphose and exhibits paedomorphosis. While it is clear that salamander paedomorphosis is associated with genetic changes that delay developmental timing, it is not clear when and how these changes manifest during development. It is possible that paedomorphic and metamorphic larvae show equivalent patterns of developmental until late in the larval period, when brain regions become competent to stimulate the release of metamorphic hormones. To test this hypothesis, I compared gene expression patterns between the brains of A. mexicanum and A. t. tigrinum larvae. In support of the developmental equivalence …
Genetic And Non-Genetic Factors That Cause Inter-Individual Variations In Cyp2a13 Gene Expression, Hong Wu
Genetic And Non-Genetic Factors That Cause Inter-Individual Variations In Cyp2a13 Gene Expression, Hong Wu
Legacy Theses & Dissertations (2009 - 2024)
The overall goal of this dissertation is to investigate the mechanisms underlying the large interindividual variations in susceptibility to lung carcinogenesis. We focused on CYP2A13, a respiratory tract-specifically expressed enzyme, which is the most efficient P450 towards bioactivation of a tobacco-related carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). The expression level of CYP2A13 varies substantially among human lung samples. Our central hypothesis is that CYP2A13 expression level is affected by both genetic regulators and non-genetic factors. The specific aims are 1) to identify the mechanisms underlying the decreased allelic expression of a CYP2A13 allele (7520C>G); 2) to identify frequent single-nucleotide polymorphisms (SNPs), associated …