Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Entire DC Network
Paclitaxel Enhances Oncolytic Potential Of Herpes Simplex Virus Type-1 In Cancer Cells, Misagh Naderi
Paclitaxel Enhances Oncolytic Potential Of Herpes Simplex Virus Type-1 In Cancer Cells, Misagh Naderi
LSU Master's Theses
Taxanes are spindle poisons that bind to and stabilize microtubules resulting in mitotic arrest. Herpes simplex Typ-1 (HSV-1) virions utilize the microtubular network for intracellular transport during both virus entry and virus egress from infected cells. It has been reported previously that taxanes may synergize with oncolytic herpes simplex viruses in the treatment of experimental prostate and breast tumors in mice. Other reports have indicated that taxanes may inhibit viral replication in infected cells. In this study the previously characterized Oncolytic Herpes Simplex Virus type 1 (OSVP), which was constructed in Kousoulas lab was used in conjugation with paclitaxel (taxol) …
Inhibitory Activity Of Ginger Oil Against Breast Cancer Cells, Namrata Karki
Inhibitory Activity Of Ginger Oil Against Breast Cancer Cells, Namrata Karki
LSU Master's Theses
Breast cancer is the leading cause of cancer related mortality in women. The estimated new cases and death for 2010 in the US for females were 207,090 and 39,840 and for men were 1,970 and 390 respectively. Breast cancer cells contain cancer stem cells (CSCs), which represent less than 5% of the total cancer cell population, but accounts for continuous proliferation and growth. Breast cancer is highly metastatic and can spread to various parts of the body. Signaling through cell surface markers, including CD44/CD24/ALDH1 in breast cancer, pro-survival factors, including Hsp90 and other client proteins, angiogenic biomarkers and telomerase activity …
In Vitro Inhibitory Activity Of Black Seed Oil And Potassium Chloride Against The Biomarkers Of Triple Negative Breast Cancer, Tamaratina Jombai
In Vitro Inhibitory Activity Of Black Seed Oil And Potassium Chloride Against The Biomarkers Of Triple Negative Breast Cancer, Tamaratina Jombai
LSU Master's Theses
Breast cancer is the leading cause of death among women and is highly heterogeneous in nature. One very aggressive subtype of this disease is Triple Negative Breast Cancer. Triple Negative Breast Cancer (TNBC), is a very aggressive disease characterized by the lack of expression of estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptor-2 (HER-2). TNBC patients account for approximately 15% of total breast cancer patients. This breast cancer subtype is characterized by high mortality rate, and is typically associated with poor prognosis. Current clinical methods have proven to have low success rates against TNBC, it is …