Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
Chronic Cadmium Exposure Alters Erα Dependency And Drug Sensitivity Of Breast Cancer Cells, Mathew Bloomfield
Chronic Cadmium Exposure Alters Erα Dependency And Drug Sensitivity Of Breast Cancer Cells, Mathew Bloomfield
Dissertations, Masters Theses, Capstones, and Culminating Projects
The global prevalence of breast cancer in women illustrates the importance of identifying factors that contribute to disease onset and progression. Endogenous and environmental agents that interact with estrogen receptor alpha (ERα) have been shown to play a role in breast cancer etiology. Evidence from epidemiological studies and animal models has suggested that cadmium, a heavy metal that can activate ERα, contributes to the development and progression of breast cancer. Additionally, our lab showed that chronic cadmium exposure altered the expression of several ERα-responsive genes and increased the malignancy of MCF7 breast cancer cells. Although these studies support cadmium’s function …
Targeting Estrogen Receptor Negative Breast Cancer Cells Using Diarylthiourea Analogs Of Sheta2, Hongye Zou
Targeting Estrogen Receptor Negative Breast Cancer Cells Using Diarylthiourea Analogs Of Sheta2, Hongye Zou
Dissertations, Masters Theses, Capstones, and Culminating Projects
Abstract will available after document embargo ends.