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Development Of Markers For Embryonic Reproductive Competence In Assisted Reproduction, Xin Tao

Seton Hall University Dissertations and Theses (ETDs)

In humans, early embryo development is a complex process that consists of sequential events: oocyte maturation, fertilization, embryonic growth and implantation. Disruption of these highly regulated processes results in reproductive failure and infertility. This study characterizes and describes embryonic aneuploidy, mitochondrial content level and endometrial microbial environment related to reproductive competence, in particular instances in which failure results.

To examine the molecular underpinnings of mammalian gamete and early embryo chromosome segregation, we established a comprehensive chromosomal screening (CCS) method for mice poly bodies, oocytes and embryos by the application of whole genome amplification (WGA) and next generation sequencing (NGS). First, …

Effects Of 17Β-Estradiol On Learning And Memory And Strategy Use During A Hole Board Spatial Navigation Task In Aged Male Rats, Megan Berthiaume

Seton Hall University Dissertations and Theses (ETDs)

Treatment with 17β- estradiol has been shown to ameliorate age related deficits in spatial learning and memory as well as to promote the use of an allocentric strategy during spatial navigation. While the majority of research using 17β- estradiol has been done using females rodents, there have been studies showing an improvement in spatial learning and memory and promoted use of allocentric strategies in spatial navigation in males as well. In males testosterone (T) is metabolized into estradiol by aromatase. As circulating levels of T decline with aging there is less available T to be metabolized into estradiol. The current …