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Articles 1 - 28 of 28
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Myokine Probdnf-P75ntr Signaling In Skeletal Muscle Injury And Sterile Inflammation, Katherine Aby
Myokine Probdnf-P75ntr Signaling In Skeletal Muscle Injury And Sterile Inflammation, Katherine Aby
Dissertations and Theses
Originally discovered in the brain, brain-derived neurotrophic factor (BDNF) has been shown to be expressed and released from skeletal muscle as a myokine. However, the function of myokine BDNF is not fully understood. Of interest to this study is the function of the BDNF precursor proBDNF in skeletal muscle. We first show that skeletal muscle expresses unique BDNF splice variants compared to the brain, and at the protein level, skeletal muscle expresses significantly more proBDNF than mature BDNF under basal conditions. Consistent with this, expression of major protein convertases in skeletal muscle were significantly lower. The role of myokine proBDNF …
The Role Of Uchl1 In Skeletal Muscle Development And Regeneration, Ryan Antony
The Role Of Uchl1 In Skeletal Muscle Development And Regeneration, Ryan Antony
Dissertations and Theses
Ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that was originally discovered in neurons. UCHL1 is also expressed in skeletal muscle, but its functions remain to be fully understood. Myogenesis is a critical process involved in embryonic development, growth, and regeneration following injury. Skeletal muscle injury is prevalent in trauma and surgical procedures, and skeletal muscle ischemia-reperfusion (IR) injury is a common yet dangerous public health problem. Here we reported that UCHL1 negatively affects muscle growth during aging as well as the regeneration process following IR injury. First, we observed that UCHL1 knockdown in C2C12 myoblasts resulted in increased …
Impacts Of Environmental Stressors On Native South Dakota Amphibian Physiology And Survival, Danielle Jean Galvin
Impacts Of Environmental Stressors On Native South Dakota Amphibian Physiology And Survival, Danielle Jean Galvin
Dissertations and Theses
Amphibian populations around the world are declining, with some of the most likely drivers behind these declines including emerging infectious diseases and environmental contaminants. To address major gaps in the current literature, I sought to evaluate the effect of two major environmental stressors on various aspects of amphibian physiology: emerging infectious diseases and environmental contaminants. Emerging infectious diseases of amphibians include fungal, viral, and parasitic pathogens which have expanded in host range, either geographically or in competent host species. Environmental contaminants include chemicals which may be naturally occurring in the environment, or which may be introduced to the environment, often …
Mitochondrial Roles In Developmentally Programmed Heart Disease, Eli John Louwagie
Mitochondrial Roles In Developmentally Programmed Heart Disease, Eli John Louwagie
Dissertations and Theses
Offspring of diabetic and obese mothers (ODOM) have greater risks of heart disease at birth and later in life. However, prevention is hindered because underlying mechanisms are poorly understood. Mounting studies in the Developmental Origins of Health and Disease field suggest that mitochondria play key roles in developmentally programmed heart disease similar to the roles they play in cardiomyopathy in adults with diabetes and obesity. However, whether mitochondria are responsible for the short[1]and long-term cardiac disease seen in ODOM remains unknown. Here, we sought to delineate the roles of mitochondria in the hearts of ODOM, determine whether mitochondria are playing …
Unraveling The Regulatory Basis Of The Desiccation Tolerance Trait In Selaginella Lepidophylla, Madhavi Anuradha Ariyarathne Hewa Babarandhage
Unraveling The Regulatory Basis Of The Desiccation Tolerance Trait In Selaginella Lepidophylla, Madhavi Anuradha Ariyarathne Hewa Babarandhage
Dissertations and Theses
Desiccation tolerance was a crucial adaptation for plants during their transition to terrestrial environments. Some spike mosses, including S. lepidophylla, have evolved the remarkable ability to tolerate extreme desiccation, enabling survival in arid regions of the world. However, the regulatory basis of this trait remains unknown. This dissertation aims to unravel the genetic basis of desiccation tolerance in Selaginella lepidophylla and its potential for improving crop abiotic stress tolerance. To achieve this goal, three objectives were pursued. Objective 1 focused on determining the regulatory role of the SlbHLH transcription factor (TF) by overexpressing it in Arabidopsis thaliana to assess its …
Monitoring Movement And Range Expansion Of Silver And Bighead Carp (Hypophthalmichthys Molitrix, H. Nobilis) In South Dakota Tributaries Of The Missouri River, Lindsey Ann Pearl Labrie
Monitoring Movement And Range Expansion Of Silver And Bighead Carp (Hypophthalmichthys Molitrix, H. Nobilis) In South Dakota Tributaries Of The Missouri River, Lindsey Ann Pearl Labrie
Dissertations and Theses
Invasive species, climate change, human impacts on the landscape, flooding, and drought are all dynamic factors that greatly impact the Missouri River and its tributaries in eastern South Dakota. Invasive Carp, and more specifically, Bighead (Hypophthalmichthys nobilis) and Silver Carp (H. molitrix), first invaded the Missouri River watershed in eastern South Dakota in the late 1990s and have since spread throughout the basin downstream of Gavin’s Point Dam. The first chapter of this study uses environmental DNA (eDNA) in the context of two major barriers to fish movement in the Vermillion and Big Sioux Rivers to determine potential presence and …
Application Of Hierarchical Species Distribution Models To Avian Species Of South Dakota And The Upper Missouri River Basin, Reza Goljani Amirkhiz
Application Of Hierarchical Species Distribution Models To Avian Species Of South Dakota And The Upper Missouri River Basin, Reza Goljani Amirkhiz
Dissertations and Theses
Recognizing the distributional patterns of species can inform management actions and increase scientific knowledge about species. Habitat Suitability Models (HSMs) are valuable tools in modeling species’ niches and effects of climate change and anthropogenic and natural disturbances on species’ distributions and abundances. In this dissertation, I expanded the application of hierarchical HSMs for a rare bird (Virginia’s warbler) and an economically valuable bird (ring-necked pheasant) in South Dakota. Also, we developed multiscale HSMs for grassland birds in the Upper Missouri River Basin (UMRB) to quantify current habitat associations and predict the influences of climate and landcover change associated with the …
Of Transcription Factor And Transformation: Elucidating Gene Function In The Common Ice Plant, Mesembryanthemum Crystallinum, Chinenye Lilian Izuegbunam
Of Transcription Factor And Transformation: Elucidating Gene Function In The Common Ice Plant, Mesembryanthemum Crystallinum, Chinenye Lilian Izuegbunam
Dissertations and Theses
Abiotic stresses negatively affect plant growth and development across the globe, which also affect the production of food, feed, biofuel, and fiber to meet the demands of a growing population. Thus, developing novel strategies to increase abiotic stress tolerance in crops is necessary. One of these strategies is exploring transcription factors (TFs) in Crassulacean Acid Metabolism (CAM) plants to improve plant abiotic stress tolerances. Therefore, the first objective of this dissertation determine the abiotic stress tolerance function of a CAM TF, McHB7opt in Arabidopsis. This study found that McHB7opt increased stress-responsive pathways related to seed germination and early seedling development. …
The Effects Of Anthropogenic Modification To The Landscape On Turtle Distribution And Health In South Dakota, Anna C. Kase
The Effects Of Anthropogenic Modification To The Landscape On Turtle Distribution And Health In South Dakota, Anna C. Kase
Dissertations and Theses
The Missouri River is a dynamic ecosystem that has been affected by anthropogenic modification and activity. The implementation of mainstem dams, reservoir formation, pollution, and non-native species invasions have greatly impacted this habitat and its constituents, particularly the false map turtle (Graptemys pseudogeographica). False map turtles are listed as a state threatened species in South Dakota and a focused large-scale assessment of their distribution and health has not been conducted since the 1960s. To address the gap in knowledge of how anthropogenic modifications to the Missouri River have impacted false map turtle distributions and health, the effect of a common …
Documenting Range Expansion Of Two Invasive Tick (Acari:Ixodidae) Species In Eastern South Dakota, Braden Wojahn
Documenting Range Expansion Of Two Invasive Tick (Acari:Ixodidae) Species In Eastern South Dakota, Braden Wojahn
Dissertations and Theses
This project documents the expanded zoogeographic ranges of the blacklegged tick (Ixodes scapularis) and lone star tick (Amblyomma americanum) within eastern South Dakota. Ticks are important when considering a “One Health” approach, as many species are competent vectors of zoonotic pathogens causing human diseases and conditions such as Lyme disease, tularemia, rickettsia, and alpha gal syndrome. The research involved constitutes two steps. First, tick surveillance was conducted in eastern counties of South Dakota, spanning March 2021 through August 2022. Surveillance took place along edge habitat at recreation areas, state and public parks, wildlife management areas and refuges, and other natural …
Cop9 Signalosome Promotes Neointimal Hyperplasia Via Deneddyaltion And Csn5-Mediated Nuclear Export, Samiksha Giri
Cop9 Signalosome Promotes Neointimal Hyperplasia Via Deneddyaltion And Csn5-Mediated Nuclear Export, Samiksha Giri
Dissertations and Theses
Neointimal hyperplasia (NH) is a common pathological response to vascular injury and mediated primarily by vascular smooth muscle cell (VSMC) migration and proliferation. The COP9 signalosome (CSN) is formed by 8 canonical subunits (CSN1 through CSN8) with its deneddylation activity residing in CSN5. Each or some of CSN subunits may have deneddylation-independent function but this is not well established. Despite the CSN being known to be a key regulator of protein degradation, its role in vascular biology remains obscure. The present study was conducted to fill these critical gaps.Our immunohistochemistry analyses revealed substantially higher CSN5 levels in the neointimal VSMCs …
Ser14-Rpn6 Phosphorylation Mediates The Activation Of 26s Proteasomes By Cyclic Amp And Protects Against Cardiac Proteotoxic Stress In Mice, Liuqing Yang
Dissertations and Theses
A better understanding of how proteasome activity is regulated can facilitate the search for proteasome enhancement strategies for disease treatment. A cell culture study shows cAMP-dependent protein kinase (PKA) activates 26S proteasomes by phosphorylating Ser14 of RPN6 (pS14-RPN6), but this discovery and its physiological significance remain to be established in vivo. To test the hypothesis that pS14-RPN6 mediates the activation of proteasomes by PKA and reduces proteotoxicity in animals, two knock-in mouse models with Ser14 of endogenous Rpn6 mutated to either Ala (S14A) or Asp (S14D) to respectively block or mimic pS14-Rpn6 were created. In a PKA-dependent manner, cAMP augmentation …
Factors Influencing Hard Running Distances In Ncaa Division I Female Soccer Players, Isaac A. Sam
Factors Influencing Hard Running Distances In Ncaa Division I Female Soccer Players, Isaac A. Sam
Dissertations and Theses
As the total distances covered in soccer games have remained relatively constant, the hard running distances covered by players have shown varying changes due to the higher physical demands and dynamics of team running performances. Although factors affecting the total distances covered in a match are multifactorial, no study has specifically examined match performance indicators (MPI) that impact hard running distances (HRD). Consequently, the purpose of this study was to better understand how MPI (hard running efforts, turnovers, minutes played, duels won, duels lost, and pass completions) are associated with HRDs and to investigate how each variable contributes to HRDs …
Molecular Investigation Of Minor Genomic Populations And Biological Exposures In Human Health, Brandon Ned Johnson
Molecular Investigation Of Minor Genomic Populations And Biological Exposures In Human Health, Brandon Ned Johnson
Dissertations and Theses
The study of genetics has contributed to countless discoveries related to human health and disease. However, the complexities of human biology reside not only in the genome but also in the contributions from environmental exposures, as measured via the classical twin design. To understand the influence of biological exposures, I implemented study designs to explore both the health associations and propagation of foreign genetic material. Microchimerism has been studied for association with several clinical conditions, and I further investigated if male microchimerism could elucidate the etiology of Mayer-Rokitansky-Küster-Hauser syndrome. Prevalence of male microchimerism in women with no history of pregnancy …
Patterns And Process Of Sandbar Revegetation On The Missouri National Recreational Rive, Amena Begum Ruma
Patterns And Process Of Sandbar Revegetation On The Missouri National Recreational Rive, Amena Begum Ruma
Dissertations and Theses
Decades of flow regulation have reduced sandbar area and recruitment of cottonwood and willow along the Missouri River. Conflicts exist between managing sandbars for habitat (removing vegetation) for threatened sandbar-nesting birds (i.e., Piping Plover) and allowing natural recruitment of early successional riparian woodland (set-aside bars) that may support other species and ecological values. Recent changes in topography, geomorphology, and vegetation were examined on sandbars that have been “set aside” from management within seven reaches of the Missouri National Recreational River (MNRR) in southeastern South Dakota, USA. An existing time series of maps of sandbar landcover, derived from satellite imagery, was …
Investigation Of Nuclear Envelope-Associated Progeria Proteins During Nuclear Envelope Rupture, Rhiannon Marie Sears
Investigation Of Nuclear Envelope-Associated Progeria Proteins During Nuclear Envelope Rupture, Rhiannon Marie Sears
Dissertations and Theses
The nuclear envelope (NE) is a specialized extension of the endoplasmic reticulum critical for the proper protection and organization of the genome. This interphase-only structure is host to several proteins and their interacting constituents that have various and diverse cellular roles. Mutations in NE constituents are associated with several human diseases. A subset of these diseases, known as progeria syndromes, are characterized by the premature presentation of physiological aging in a variety of tissues. Mutations in the genes LMNA and BANF1, which encode the A-type lamins and barrier-to-autointegration factor (BAF), can lead to these multisystem progeroid diseases. Though the underlying …
Single Cell Lineage Tracing Reveals Mechanisms Of Tumor Initiation And Chemoresistance In Small Cell Lung Cancer, Hannah Wollenzien
Single Cell Lineage Tracing Reveals Mechanisms Of Tumor Initiation And Chemoresistance In Small Cell Lung Cancer, Hannah Wollenzien
Dissertations and Theses
Small Cell Lung Cancer (SCLC) is a devastating disease characterized by a very low two-year survival rate and almost universal acquisition of chemoresistance. Nearly all patients have tumors driven by functional inactivation of the tumor suppressors Rb and p53, but despite the uniform origins of this tumor, not all patients are genetically or phenotypically identical. SCLC can be subtyped into four unique molecular subtypes, determined by the expression of ASCL1, NEUROD1, POU2F3, or YAP1. These subtypes are plastic, and subtype switching after chemotherapy has been documented. Without the understanding of how tumor heterogeneity arises, we cannot solve the challenge of …
Molecular Genetic Investigation Of Twins, Families, And Populations, Jeffrey John Beck
Molecular Genetic Investigation Of Twins, Families, And Populations, Jeffrey John Beck
Dissertations and Theses
Twins have long been of interest for illuminating genetic and environmental influences on human traits and diseases. These explorations have been accelerated by the substantial amount of information collected from twins and their families participating in twin registers around the world. In this dissertation, I review what is known and what remains unknown about the biology and genetics of twins and the underlying twinning process. To elucidate additional genetic factors of the twinning process, I employed pedigree-based analysis to identify genetic regions shared among distantly related mothers of dizygotic twins. The shared regions may potentially contain rare genetic variants with …
Digging For Information: Investigating The Efficacy Of Tracking And Augmenting Lacunicambarus Nebrascensis For Endangered Dragonfly Conservation, Danielle Elaine Tesar
Digging For Information: Investigating The Efficacy Of Tracking And Augmenting Lacunicambarus Nebrascensis For Endangered Dragonfly Conservation, Danielle Elaine Tesar
Dissertations and Theses
Restoration and preservation of habitat for threatened and endangered species can proceed in many ways. Augmentation strategies can be used to supplement threatened and endangered populations or the species and resources on which those imperiled species depend. Comprehensive knowledge of species movement and home range is necessary to formulate effective augmentation plans. For freshwater burrowing crayfish, this type of information is generally lacking. The studies reported here were designed to acquire detailed information that is essential for augmentation of the plains devil crayfish, Lacunicambarus nebrascensis (formerly, Cambarus diogenes). Although L. nebrascensis populations are not considered threatened, this crayfish provides vital …
Biofilmgeneset: Leveraging Multi-Omics Data Mining And Ica To Discover Biofilm Stage Genes Of Interest From Condition-Specific Expression Dataset, Mathew Olakunle Alaba
Biofilmgeneset: Leveraging Multi-Omics Data Mining And Ica To Discover Biofilm Stage Genes Of Interest From Condition-Specific Expression Dataset, Mathew Olakunle Alaba
Dissertations and Theses
Biofilm formation occurs in the attachment, colony, maturation, and dispersion stages. Understanding the molecular basis at every point of this process is essential to developing efficient diagnostics devices and effective antibiofilm agents. Gene expression data provide molecular insight for both static and temporal biofilm development. The most used analytic techniques for biofilm gene expression data are clustering and network inference algorithms, which class genes with similar expressions across the samples. However, these methods are inherently deficient because they do not capture gene(s) expressed in a subset of the samples. These subsets might be unique to a developmental stage, for example. …
Nonhematopoietic Erythropoietin: A Study Of Signaling, Structure, And Behavior, Nicholas John Pekas
Nonhematopoietic Erythropoietin: A Study Of Signaling, Structure, And Behavior, Nicholas John Pekas
Dissertations and Theses
Erythropoietin (EPO) is a cytokine hormone known for initiating red blood cell proliferation by binding to its homodimer receptor (EPOR)2 in the bone marrow. Recent progress in neurobiology has shown that EPO also exerts robust neurotrophic and neuroprotective activity in the CNS. It is widely thought that EPO’s neurotrophic activity is centrally involved in its antidepressant and cognitive enhancing effects. However, EPO’s potent erythropoietic effects prevent it from being used in the clinic to treat psychiatric disorders. A chemically engineered non-erythropoietic derivative of EPO, carbamoylated EPO (CEPO), produces psychoactive effects without activating hematopoiesis. However, CEPO is expensive to produce and …
Framework For The Evaluation Of Perturbations In The Systems Biology Landscape And Inter-Sample Similarity From Transcriptomic Datasets — A Digital Twin Perspective, Mariah Marie Hoffman
Framework For The Evaluation Of Perturbations In The Systems Biology Landscape And Inter-Sample Similarity From Transcriptomic Datasets — A Digital Twin Perspective, Mariah Marie Hoffman
Dissertations and Theses
One approach to interrogating the complexities of human systems in their well-regulated and dysregulated states is through the use of digital twins. Digital twins are virtual representations of physical systems that are descriptive of an individual's state of health, an object fundamentally related to precision medicine. A key element for building a functional digital twin type for a disease or predicting the therapeutic efficacy of a potential treatment is harmonized, machine-parsable domain knowledge. Hypothesis-driven investigations are the gold standard for representing subsystems, but their results encompass a limited knowledge of the full biosystem. Multi-omics data is one rich source of …
Ecological Changes Of The Lower Niobrara River Valley And Lewis And Clark Lake Delta From Past To Present, Madalyn Christine Bollig
Ecological Changes Of The Lower Niobrara River Valley And Lewis And Clark Lake Delta From Past To Present, Madalyn Christine Bollig
Dissertations and Theses
Over half of the world’s large river systems are impacted by dams. These may prevent sediment flow downstream, resulting in accumulation in the upstream reservoir. On the Missouri River, deltas and associated backwater-affected areas occur in nine locations across six reservoirs. One of these, the Lewis and Clark Lake delta-backwater, is influenced by sediment inputs from both the Missouri River and the Niobrara River. While the extension of the prograding delta into the reservoir has been well documented, there has been little research on upstream (backwater) effects of the delta on the lower Niobrara River. This study examined ecological changes …
Mental Fatigue On Landing Performance, Madison Marie Gaffney
Mental Fatigue On Landing Performance, Madison Marie Gaffney
Dissertations and Theses
Mental fatigue has been shown to impair physical performance, especially for endurance-based sports. However, little research has been done regarding the impacts of mental fatigue on shorter maximal effort movements during a common sport related activity such as the depth jump. The purpose of this study was to investigate the effects of mental fatigue on short maximal performance efforts and predisposing biomechanical variables for non-contact ACL tears during depth-jumps in 18 Division I female soccer players. Each participant completed five depth jumps, followed by a 30-minute Stroop task to induce mental fatigue, and then completed five more depth jumps. Multiple …
(R)-2,5-Dimethoxy-4-Iodoamphetamine [(R)-Doi] Influences Coping Strategies To An Escapable Social Stress, Kevin Thomas Krupp
(R)-2,5-Dimethoxy-4-Iodoamphetamine [(R)-Doi] Influences Coping Strategies To An Escapable Social Stress, Kevin Thomas Krupp
Dissertations and Theses
Depressive mood disorders are a leading cause of disability worldwide and pharmacological treatments for these disorders are inadequate, requiring new compounds with greater efficacy be investigated. The etiology of depression is heterogeneous; however, it is well established that stress exposure, and the proinflammatory effects of stress have a major role. Psychedelic compounds have rapid and long-lasting anxiolytic and antidepressive effects in humans and animal models of stress induced affective behavior. However, it is not completely understood how these compounds produce such rapid effects. We investigated whether the psychedelic compound (R)-2,5-dimethoxy-4-iodoamphetamine [(R)-DOI], a selective 5-HT2A partial agonist with potent anti-inflammatory properties, …
Modulation Of Stress-Induced Behaviors Through Orexinergic Signaling In The Basolateral Amygdala, Jazmine D W Yaeger
Modulation Of Stress-Induced Behaviors Through Orexinergic Signaling In The Basolateral Amygdala, Jazmine D W Yaeger
Dissertations and Theses
Stress initiates behavioral disturbances, which are often seen as symptoms of psychiatric disorders, like post-traumatic stress disorder (PTSD), depression, and anxiety. While stress is involved in the formation of disordered states, only certain individuals are vulnerable to, and therefore experience, these outcomes. Further, females are more likely to be diagnosed with stress-induced psychiatric disorders. Elements within stress neurocircuitry offer insight into differential behavioral outcomes associated with stressful experiences; and the basolateral amygdala (BLA), where pro- and anti-stress signals are integrated, is likely an important mediator in phenotype development. The orexin system, too, while being strongly associated with sleep, motivation, and …
Molecular Mechanisms Underlying The Suppression Of Cardiomyocyte Necroptosis By The Cop9 Signalosome In Mice, Megan T. Lewno
Molecular Mechanisms Underlying The Suppression Of Cardiomyocyte Necroptosis By The Cop9 Signalosome In Mice, Megan T. Lewno
Dissertations and Theses
Background: Within a large subset of heart failure, cardiac ubiquitin-proteasome system (UPS) inadequacy is causative. A vital UPS regulator is the COP9 signalosome (CSN). The CSN holocomplex is formed by 8 unique protein subunits (COPS1~COPS8) and regulates Cullin-RING ligases via Cullin deneddylation. Cardiomyocyte-restricted knockout (cko) of Cops8 causes massive cardiomyocyte necroptosis via the RIPK1-RIPK3-MLKL pathway, resulting in dilated cardiomyopathy (DCM) and shortened lifespan in mice. CSN’s deneddylase resides in COPS5 and Cops5-cko has not been explored. It is important to investigate how the necroptotic pathway within cardiomyocytes is activated in Cops8-cko mice as cardiomyocyte necroptosis has been shown to play …
Impacts Of Environmental And Anthropogenic Stressors On Amphibian Welfare, Diversity, And Distribution In The Upper Missouri River Basin, Kaitlyn Campbell
Impacts Of Environmental And Anthropogenic Stressors On Amphibian Welfare, Diversity, And Distribution In The Upper Missouri River Basin, Kaitlyn Campbell
Dissertations and Theses
Climate change and anthropogenic stressors have contributed to rapid declines among various taxonomic groups; however, amphibian declines have been particularly intense and primarily stemmed from warming temperatures, habitat loss, exposure to contaminants, disease, and their subsequent interactions. Several climate mitigation strategies, like Bioenergy with Carbon Capture and Storage, have been proposed to alleviate the impact of rising temperatures; however, these proposals often fail to recognize and quantify the true impact on fauna, including changes in species distributions. To address this critical gap in knowledge, this research identified current amphibian distributions in the Upper Missouri River Basin and projected distribution changes …