Digital Commons Network^™

A Developmental Study Of The Nmda Receptor, Katherine M. Flynn

Dissertations, Theses, and Capstone Projects

The N-methyl-D-aspartate type of glutamate receptor (NMDAR) is involved in the regulation of many neural functions, including neuroendocrine modulation of the vertebrate brain-pituitary-gonad axis. We have used a freshwater teleost, the platyfish (Xiphophorus maculatus), to document age- and gender-specific variations in NMDAR properties. We first localized immunoreactive (ir-) NMDAR in male and female platyfish brain at four stages of the lifespan. Distribution was limited to cells of the nucleus olfactoretinalis (NOR), a gonadotropin releasing hormone-containing nucleus. The number of ir-NMDAR cells was increased in pubescent and mature females when compared to immature and senescent animals. In …