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Epigenetic Regulation Of Genomic Imprinting During Early Mammalian Embryonic Development, Chelsea Marcho Nov 2018

Epigenetic Regulation Of Genomic Imprinting During Early Mammalian Embryonic Development, Chelsea Marcho

Doctoral Dissertations

Mammalian development involves remarkable changes, starting from a single-cell, totipotent zygote and ending with a developed organism comprised of diverse cells types with distinct morphologies, structures, and functions. Within three days of murine development, the two parental genomes merge into a single nucleus, begin zygotic gene expression, undergo epigenetic remodeling, and make the first lineage decisions. Diversity in cell-types is possible even though cells share the same genome. This diversity is achieved by the tight regulation of differential transcriptional programs. There are many ways these transcriptional programs can be initiated. Epigenetic alterations to the genome can drive transcriptional changes. Epigenetic …


Breakups And Betrayals In Emerging Adulthood: A Developmental Perspective Of Relationship Dissolution And Infidelity, Jerika C. Norona Aug 2018

Breakups And Betrayals In Emerging Adulthood: A Developmental Perspective Of Relationship Dissolution And Infidelity, Jerika C. Norona

Doctoral Dissertations

This dissertation includes two studies that focus on romantic experiences in emerging adulthood (ages 18-25), romantic dissolution (Study 1) and extradyadic intimacy (Study 2), and their relationship with developmental and individual factors. Each study uses two unique community samples of emerging adults who have attended college as well as those who have not attended college in the past. Importantly, both studies examine romantic dissolution and extradyadic intimacy from a developmental perspective, taking into account the salient developmental tasks of independence and interdependence faced by young people. Additionally, individual factors, including perceptions of emerging adulthood (Study 1), attachment style (Study 2), …