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Sprouty2 Deficiency In Mice Leads To The Development Of Achalasia, Benjamin Lee Staal

Masters Theses

Sprouty 2 (Spry2), one of the four mammalian Spry family members, is a negative feedback regulator of many receptor tyrosine kinases (RTKs) signaling including Met. It fine-tunes RTKs signaling through multiple levels of regulations starting from RTK itself to several downstream molecules that are crucial for signal transduction. To understand what role Spry2 might play during developmental processes, we created a Spry2 conventional knockout mouse in which Spry2 expression is replaced by enhanced green fluorescent protein (EGFP) reporter. Spry2 appears to be expressed in mouse embryo and in many adult tissues, and Spry2- deficient mice have smaller body size and …