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Development And Feasibility Testing Of Prompt-Care, An Ehealth System For Collection And Use Of Patient-Reported Outcome Measures For Personalized Treatment And Care: A Study Protocol, Afaf Girgis, Geoff P. Delaney, Anthony Arnold, Andrew Alexis Miller, Janelle V. Levesque, Nasreen Kaadan, Martin G. Carolan, Nicole Cook, Kenneth Masters, Thomas T. Tran, Tiffany Sandell, Ivana Durcinoska, Martha Gerges, Sandra Avery, Weng Ng, Stephen Della-Fiorentina, Haryana M. Dhillon, Ashley M. Maher
Development And Feasibility Testing Of Prompt-Care, An Ehealth System For Collection And Use Of Patient-Reported Outcome Measures For Personalized Treatment And Care: A Study Protocol, Afaf Girgis, Geoff P. Delaney, Anthony Arnold, Andrew Alexis Miller, Janelle V. Levesque, Nasreen Kaadan, Martin G. Carolan, Nicole Cook, Kenneth Masters, Thomas T. Tran, Tiffany Sandell, Ivana Durcinoska, Martha Gerges, Sandra Avery, Weng Ng, Stephen Della-Fiorentina, Haryana M. Dhillon, Ashley M. Maher
Illawarra Health and Medical Research Institute
Background: Patient-reported outcome (PRO) measures have been used widely to screen for depression, anxiety, and symptoms in cancer patients. Computer-based applications that collect patients' responses and transfer them to the treating health professional in real time have the potential to improve patient well-being and cancer outcomes.
Objective: This study will test the feasibility and acceptability of a newly developed eHealth system which facilitates PRO data capture from cancer patients, data linkage and retrieval to support clinical decisions and patient self-management, and data retrieval to support ongoing evaluation and innovative research.
Methods: The eHealth system is being developed in consultation with …
Recent Highlights In The Development Of Isatin-Based Anticancer Agents, Kara L. Vine, Lidia Matesic, Julie M. Locke, Danielle Skropeta
Recent Highlights In The Development Of Isatin-Based Anticancer Agents, Kara L. Vine, Lidia Matesic, Julie M. Locke, Danielle Skropeta
Illawarra Health and Medical Research Institute
Isatin (1H-indole-2,3-dione) and its derivatives are responsible for a broad spectrum of biological activities. Among these the cytotoxic and antineoplastic properties have been the most widely reported. The synthetic versatility of the isatin, due to its privileged scaffold, has led to the generation of a large number of structurally diverse derivatives which include analogues derived from either mono-, di-, and trisubstitution of the aryl ring A, and/or those obtained by derivatisation of the isatin nitrogen and C2/C3 carbonyl moieties. These compounds inhibit cancer cell proliferation and tumour growth via interaction with a variety of intracellular targets such as DNA, telomerase, …