Digital Commons Network^™

Law For My Enemies: An Argument For Federal Cannabis Legalization, Lauren Romero

Seattle Journal for Social Justice

No abstract provided.

Lessons Of The Opioid Epidemic - December 3, 2021, Mitchell J. Cohen, Md, Joey Flaxer, Md, Phd, Marianna Lanoue, Phd

Department of Psychiatry and Human Behavior Grand Rounds

No abstract provided.

How High? Trends In Cannabis Use Prior To First Admission To Inpatient Psychiatry In Ontario, Canada, Between 2007 And 2017, Taylor Mcguckin, Mark A. Ferro, David Hammond, Shannon Stewart, Bridget Maloney-Hall, Nawaf Madi, Amy Porath, Christopher M. Perlman

Paediatrics Publications

Objectives: To examine the trends in cannabis use within 30 days of first admission to inpatient psychiatry in Ontario, Canada, between 2007 and 2017, and the characteristics of persons reporting cannabis use. Methods: A retrospective cross-sectional analysis was conducted for first-time admissions to nonforensic inpatient psychiatric beds in Ontario, Canada, between January 1, 2007, and December 31, 2017, using data from the Ontario Mental Health Reporting System (N = 81,809). Results: Across all years, 20.1% of patients reported cannabis use within 30 days of first admission. Use increased from 16.7% in 2007 to 25.9% in 2017, and the proportion with …

Exploring Health And Fitness In Cannabis And Cannabidiol Users, Blake Butler

Master's Theses

Cannabis has been reported to decrease fatigue symptoms and aide in sleep quality, among other use cases. It is unclear whether cannabis is linked to alterations in physical activity and fitness. Cannabidiol, an active compound in cannabis, has also been reported to decrease fatigue symptoms and aide in sleep. Cannabidiol has been reported to aide in recovery from physical activity, but there is no clear connection between cannabidiol use and the likelihood of engaging in physical activity. PURPOSE: The aim of this study was to explore fatigue, sleep, physical activity, fitness markers, and fitness outcomes in cannabis and cannabidiol users. …

Impact Of Cannabis Use On Least Pain Scores Among African American And White Patients With Cancer Pain: A Moderation Analysis, Salimah H Meghani, Ryan Quinn, Rebecca Ashare, Kristin Levoy, Brooke Worster, Mary Naylor, Jesse Chittams, Martin Cheatle

Department of Medical Oncology Faculty Papers

Introduction: Based on many published reports, African American patients with cancer experience higher pain severity scores and lower pain relief than White patients. This disparity results from undertreatment of pain and is compounded by low adherence to prescribed non-opioid and opioid analgesics among African American patients with cancer. While nearly one in four patients use cannabis to manage cancer-related symptoms, less is known about how cannabis use influences pain relief in this patient population.

Methods: This study is based on preliminary data from an ongoing study of longitudinal outcomes of opioid therapy among African American and White patients with cancer. …

Cannabis And Cannabidiol Use In Active Individuals: A Survey Of Timing And Reasons For Use, Matthew M. Schubert, Jamie E. Hibbert, Richard Armenta, Erik A. Willis, Whitney Ogle

International Journal of Exercise Science: Conference Proceedings

The use of cannabis for medicinal and recreational purposes is widespread across the globe. However, relatively little is known regarding the use of cannabis and its constituents among athletic populations. PURPOSE: The aim of this study was to examine timing of cannabis use relative to exercise, reasons for use, forms of consumption, and sources of information in active adults. METHODS: This cross-sectional survey was administered electronically beginning in September 2020. Participants were recruited through social media advertisements, email blasts, and word of mouth. Data were collected on health and exercise habits, use of cannabis/cannabidiol (CBD), reasons for use, …

The Effects Of Recreational Cannabis Access On Labor Markets: Evidence From Colorado, Avinandan Chakraborty, Jacqueline Doremus, Sarah Stith

Economics

Recreational cannabis markets possibly increase labor demand through investments in facilities for growing, processing, and retail sales of cannabis, as well as through other industries such as manufacturing, leisure, and hospitality. However, this increase in labor demand may vary substantially across counties within a state as most states with legal recreational canna-bis allow individual counties to ban commercial cannabis sales. Meanwhile, labor supply may change through positive and negative effects from cannabis use. Using county-level Colorado data from 2011 to 2018 and exploiting variation across counties in the existence and timing of the start of dispensary sales, we test for …

Synthesis, Characterization And Stress-Testing Of A Robust Quillaja Saponin Stabilized Oil-In-Water Phytocannabinoid Nanoemulsion, Abhinandan Banerjee, Justin Binder, Rayan Salama, John F. Trant

Chemistry and Biochemistry Publications

Background

This study describes the design, optimization, and stress-testing of a novel phytocannabinoid nanoemulsion generated using high-pressure homogenization.QNaturale®" role="presentation">QNaturale®, a plant-derived commercial emulsifier containing quillaja saponin, was used to stabilize the lipid phase droplets in water. Stress-testing was performed on this nanoemulsion in order to evaluate its chemical and colloidal stability under the influence of different environmental factors, encompassing both physical and chemical stressors.

Methods

Extensive optimization studies were conducted to arrive at an ideal nanoemulsion formulation. A coarse emulsion containing 16.6 wt% CBD-enriched cannabis distillate and 83.4 wt% carrier (soybean) oil dispersed in 10 wt%QNaturale®" role="presentation">QNaturale®

(1.5 …

Effects Of Prenatal Cannabis Exposure On Offspring Emotional Development And Stress Response, Alexandra Pritchett

Dissertations, Theses, and Capstone Projects

While cannabis may be used by women during pregnancy, its effects on their offsprings’ developing stress response system are still largely unknown. The binding sites for the active chemicals in cannabis are operational at early time points in fetal development and are expressed in key limbic brain structures. The body’s natural endocannabinoid system serves as an important regulator of the stress response. Longitudinal studies have associated prenatal exposure with increased fearfulness and mood disturbances in offspring, but, despite the growing evidence of emotional dysfunction, there remains a critical gap in knowledge explaining how early prenatal exposure may lead to future …

Participatory Research On The Prevalence Of Multi-Substance Vaping In College Students, Miranda Worthen, Isra Ahmad

Faculty Research, Scholarly, and Creative Activity

Objectives To assess electronic nicotine delivery system (ENDS) use and vaping behaviors and attitudes in college students.

Methods A student-faculty partnership administered a cross-sectional survey to undergraduate students (N = 339) in 2019.

Results 49.8% of students reported using ENDS or vaping in the past 30 days. 48.9% of students who vaped reported vaping more than one substance in the past 30 days. The most commonly vaped substances were cannabis (34.9%), nicotine (26.7%), and flavor (19.2%). Reasons for initiating ENDS use were social (64.8%), for the high (40.8%), and for the flavor (32.4%). Both users and non-users believed ENDS were …

The Cannabis Conundrum: Constitutional & Policy Concerns In Taxation Of The Marijuana Industry, Beckett Cantley, Geoffrey Dietrich

Legislation and Policy Brief

No abstract provided.

Mitigating The Effects Of Intellectual Property Colonialism On Budding Cannabis Markets, Hughie Kellner

Indiana Journal of Global Legal Studies

Globalization has reduced barriers to trade, communication, and understanding, opening opportunities that extend far beyond national borders. However, in this bounty of opportunity lie obligations, and often those obligations tie a nation's hands when trying to deal with a problem that arises. One obligation nations face is upholding the United Nations' (UN) decision to prevent the illicit use of cannabis. Another is supporting and following the World Trade Organization's (WTO) near elimination of barriers for companies to bring patent and trademark protection with them into any country they do business with. In a modern globalized economy, if a nation fails …

Resting State Functional Connectivity In The Default Mode Network: Relationships Between Cannabis Use, Gender, And Cognition In Adolescents And Young Adults, Megan Ritchay

Theses and Dissertations

Introduction: Cannabis is the most commonly used illicit substance in the United States, and nearly 1 in 4 young adults are current cannabis users. The psychoactive component of cannabis, THC, is active at cannabinoid receptors, type 1, or CB1 receptors. CB1 receptors play a critical role in neural development, and chronic cannabis use causes desensitization and downregulation of these receptors. Chronic cannabis use is associated with changes in resting state functional connectivity (RSFC) in the default mode network (DMN) in adolescents and young adults, although results are somewhat inconsistent across studies, likely due to differing methodologies. Additionally, cannabis effects appear …

Classical And Neural Network Machine Learning To Determine The Risk Of Marijuana Use, Laura Zoboroski [*], Torrey J. Wagner, Brent T. Langhals

Faculty Publications

Marijuana is the most commonly abused drug for military personnel tested at the Air Force Drug Testing Laboratory. A publicly available dataset of drug use, personality trait scores and demographic data was modeled with logistic regression, decision tree and neural network models to determine the extent to which marijuana use can be predicted using personality traits. While the logistic regression model had lower performance than the neural network model, it matched the sensitivity of prior work (0.80), achieved a high level of significance (p < 0.05) and yielded valuable inferences. It implied that younger, less educated individuals who exhibit sensation-seeking behavior and are open to experience tend to be at higher risk for THC use. A method for performing an iterative multidimensional neural network hyperparameter search is presented, and two iterations of a 6-dimensional search were performed. Metrics were used to select a family of 8 promising models from a cohort of 4600 models, and the best NN model’s 0.87 sensitivity improved upon the literature. The model met an f1 overfitting threshold on the test and holdout datasets, and an accuracy sensitivity analysis on a holdout-equivalent dataset yielded a 95% CI of 0.86 ± 0.04. These results have the potential to increase the efficacy of drug prevention and intervention programs.

American Edibles: How Cannabis Regulatory Policy Rehashes Prohibitionist Fears And What To Do About It, Jay D. Wexler, Connor Burns

Faculty Scholarship

Why can’t we buy a cannabis muffin with our morning coffee? For much of the past century, the answer was simple: cannabis was illegal. Now, however, with more and more states legalizing cannabis for adult use, the answer is far less clear. Even in those states that have legalized cannabis, the simple action of buying and eating edibles at the same location has somehow remained a pipe dream despite consumer demand. Digging a little deeper, we can see how contemporary alarmism, by rehashing the same prohibitionist rhetoric demonizing cannabis for over eighty years, has once again arisen with a new …

A Comparative Study On Cannabidiol In Melanoma Migration And Invasion: Charlotte's Web Vs. Purified Cbd, 2020–2021, Ruby Thamert

Theses

Over the last decade, much attention has been focused on compounds from Cannabis sativa in treating a variety of diseases including cancer. This study examines the abilities of two different cannabidiol oils to decrease the migration and invasion of melanoma cells in vitro. Skin cancers are the most common cancers in the world. While malignant melanoma is the least common type of skin cancer, it is the deadliest. Patients diagnosed with stage IV disease have only a 15-20% five-year survival rate even with aggressive multimodal treatment, demonstrating the need for additional therapeutic options. Because melanoma is often fatal when …

Correlation Between Brain-Derived Neurotrophic Factor And Executive Function In Cannabinoid Addiction, Lamyaa G. E. Elhamrawy, Maha A. Hamoudah, Shereen M. Ibrahim

Menoufia Medical Journal

Objectives To measure relation between brain-derived neurotrophic factor (BDNF) and executive function in cannabinoid addiction. Background In the United States, marijuana (Cannabis sativa) was the most commonly used illicit substance, the use of which usually started in the adolescence period. Patients and methods A case–controlled study was conducted on 40 addicts and 40 healthy individuals from 18 to 60 years who were recruited from both community (street) and hospital-based sampling in three Egyptian governorates from the October 1, 2017 to the end of March 2018. The control group comprised 40 healthy individuals who were selected after being age …

School Violence And Suicidal Ideation: The Mediating Roles Of Perceived School Safety And Substance Use Among Adolescents, Jordan Skalisky

Clinical Psychology Dissertations

Substance use and suicidal ideation are prevalent among adolescents. An adolescent’s school environment, such as threatening or violence-related experiences at school, may influence their perceived sense of safety, thus influencing their substance use and potentially increasing suicidal ideation. The current study examined the mediating roles of perceived school safety and substance use (alcohol use, binge alcohol use, cannabis use, and vaping) on the relationship between experienced weapon threat/violence at school and suicidal ideation. Data was used from the 2019 Youth Risk Behavior Surveillance Survey and participants were 13206 adolescents attending high school in the United States. Preliminary analyses indicated significant …

Estate Planning For Cannabis Business Owners: An Introduction, Bridget J. Crawford, Jonathan G. Blattmachr

ACTEC Law Journal

As more states legalize cannabis sales, estate planners may increasingly be called upon to advise clients with interests in cannabis-related businesses. This essay seeks to assist estate planners in two ways. First, it aims to raise general awareness of cannabis business owners’ unique concerns. Second, the essay provides an overview of some of the fundamental issues about which cannabis business owners are likely to seek estate planning advice: business formation matters, wealth transfers, the ability of trusts to own cannabis-related businesses, and gift, estate, and income tax considerations.

In most states that permit legal cannabis sales, there is limited (or …

Neurobiological Impact Of Hiv Infection And Chronic Cannabis Use, Jessica Shannon Flannery

FIU Electronic Theses and Dissertations

Neuroimaging research has identified brain alterations linked with the human immunodeficiency virus (HIV) that contribute to cognitive declines characterizing the disease. Given cannabis’s (CB’s) anti-inflammatory properties, use prevalence among people living with HIV (PLWH), and impact on neurocognition, my dissertation utilizes a between-groups study design to interrogate separate and interactive effects of HIV and CB on fMRI measures of brain activity. We investigate (1) task-based brain activity at the regional-level, (2) insular resting-state functional connectivity (rsFC) at the circuit-level, and (3) large-scale brain network interactions at the systems-level. Participants (N=114) were stratified into four groups (HIV+/CB+; HIV+/CB-; HIV-/CB+; HIV-/CB-) and …

Solitary Alcohol And Cannabis Use Among College Students During The Covid-19 Epidemic: Concurrent Social And Affective Correlates And Substance-Related Consequences, Amelia Victoria Wedel

Theses - ALL

Alcohol and cannabis use are remarkably prevalent among college students, with 60% reporting past-month alcohol use and 25% reporting past-month cannabis use. Emerging evidence suggests that a considerable portion of college students use alcohol or cannabis alone, and that rates of solitary use may be higher for cannabis than for alcohol. However, despite substantial evidence connecting solitary alcohol use with a number of affective and substance-related correlates, research on similar associations for solitary cannabis use remains lacking. Furthermore, no college studies to date have assessed solitary use of both alcohol and cannabis and consequently little is known about differences between …

Solitary Alcohol And Cannabis Use Among College Students During The Covid-19 Epidemic: Concurrent Social And Affective Correlates And Substance-Related Consequences, Amelia Victoria Wedel

Theses - ALL

Alcohol and cannabis use are remarkably prevalent among college students, with 60% reporting past-month alcohol use and 25% reporting past-month cannabis use. Emerging evidence suggests that a considerable portion of college students use alcohol or cannabis alone, and that rates of solitary use may be higher for cannabis than for alcohol. However, despite substantial evidence connecting solitary alcohol use with a number of affective and substance-related correlates, research on similar associations for solitary cannabis use remains lacking. Furthermore, no college studies to date have assessed solitary use of both alcohol and cannabis and consequently little is known about differences between …

Examining Dissociation And Cannabis Use As Links In The Pathway Between Childhood Maltreatment And Schizotypy, Brittany A. Blose

Theses

Childhood maltreatment (CM) is a risk factor for a number of psychiatric consequences, including many different mental disorders. Recent research has focused on the connection that CM has with schizotypy and how these adverse experiences during development contribute to symptomatology. Studies have demonstrated that peritraumatic dissociation experienced during CM and trait dissociative symptoms may indirectly affect the relationship between CM and schizotypic psychopathology, helping to elucidate this complex relationship. Moreover, research has indicated cannabis use, especially its use in adolescence, as a potential moderator in the CM-schizotypy relationship. That is, cannabis use further increases the risk that maltreated individuals will …

Chemical Characterization Of Toxicologically Relevant Molecules In Cannabis Concentrates And Vaporizer Aerosols, Jiries Meehan-Atrash

Dissertations and Theses

Consumption of cannabis concentrates using the relatively novel non-combustion methods dabbing and vaping has steadily grown in popularity as cannabis legalization in North America has allowed increased access to sophisticated cannabis products and technology. In order to assess the safety of these products, it is necessary to gain a chemical understanding of the decomposition reactions that occur when the active ingredients are heated in the conditions seen when dabbing or vaping. This dissertation contains a manuscript that details efforts to structurally characterize a toxic cannabis concentrate adulterant, and three manuscripts that studied the chemical decomposition of the two primary cannabis …

The Effects Of Legalization Of Recreational Cannabis In Illinois, Stephanie Chambers-Baltz

The Simon Review (Occasional Papers of the Paul Simon Public Policy Institute)

In 2019, the Illinois House passed the Cannabis Regulation and Tax Act that legalized the recreational use of cannabis. The Cannabis Regulation and Tax Act became law in the state of Illinois as of January 1, 2020, making Illinois the first state to establish such a law via state legislation, as opposed to a ballot measure approved by voters. This law allows adults aged 21 and older to legally purchase cannabis for recreational purposes. This law has significant implications for social equity and for public health. The Cannabis Regulation and Tax Act was intentionally designed to address and repair some …

Cannabidiol: An Adjunctive Therapy To Risperidone For Autistic Children Experiencing Behavioral Outbursts, Cherie Dowell

Physician Assistant Scholarly Project Papers

The purpose of this systemic literature review was to evaluate the safety, efficacy, and tolerability of medical cannabis in the treatment of aggression, irritability, and self-injurious behaviors in autistic children that are currently receiving risperidone. For this literature review, DynaMed, Cochrane, PubMed, ClinicalKey, and CINAHL were searched using various keywords and phrases. Studies that were included in this review were published after 2005, were peer-reviewed, and included systemic reviews, journal articles, clinical trials, randomized control trials, and meta-analyses. Studies that did not directly discuss autism and behavioral issues; autism treatment with risperidone, medical cannabis, or cannabidiol; that did not specifically …

Medical Cannabis And The Age Of Majority, Katharine B. Silbaugh

Faculty Scholarship

This Essay considers whether commercial cannabis retailers are adequately constrained in the sale of cannabis to 18- to 21-year-olds. It examines the intersection of the medical cannabis market, recreational cannabis market, and underlying status law regulating late adolescents aged 18 to 21. Because the age of majority licenses full medical decision-making, an 18-year-old can access medical cannabis but not recreational cannabis or alcohol. This Essay proceeds on the assumption that medical cannabis is a construct that has eased the process of achieving a legalized commercial cannabis market. The ambiguity around medical claims is comfortable in the libertarian soil of cannabis …

Health Equity, Federalism, And Cannabis Policy, Nicole Huberfeld

Faculty Scholarship

Cannabis policy is a story of complexity and dynamism laced with tension and inequity. Policy makers’ views are rapidly changing, reflected by many bills sitting before Congress. This Essay considers three of the major bills that have a more comprehensive approach to cannabis. These bills also take different approaches to the flipped federalism that could occur if the federal government were to suddenly decriminalize cannabis. The Essay next considers the state law landscape and compares it to Medicaid expansion under the Affordable Care Act, drawing a comparison to learn health equity lessons from recent health reform efforts. Federal legislation is …

Marijuana Legalization And The Role Of The Massachusetts Legislature, Sean J. Kealy

Faculty Scholarship

The public is often frustrated when Congress or their state legislature is not responsive to their policy priorities. This was especially true during the effort to legalize marijuana in Massachusetts. The legislature consistently refused to take up the issue despite public support. Legalization advocates ultimately bypassed the legislature by turning to the ballot-initiative process on three occasions: first to decriminalize possession of small amounts of marijuana, then to legalize medical marijuana, and most recently to legalize recreational marijuana. After the electorate legalized recreational marijuana, the legislature further frustrated advocates, first by delaying implementation of key parts of the law and …

Cannabis Education Training For Monterey County, Pregnant & Lactating Mothers, Ciara L. Vernon

Capstone Projects and Master's Theses

The Monterey County Health Department received a grant under Proposition 64 legalizing cannabis in California for use by adults 21 or older. The training focuses on educating the Environmental Health Bureau on the adverse effects of cannabis use during gestation and lactation. The research found an excess of women consume cannabis during gestation and lactation. A 2016 study showed that 8.5% of pregnant women between 18-25 used cannabis (Ryan, Ammerman, & O’Connor, 2018). The Environmental Health Bureau is involved in inspections and has established relationships with local dispensaries to share infographics and knowledge on the issue. The survey conducted to …