Digital Commons Network^™

Adult Food Insecurity Is Associated With Heavier Weight Preferences Among Black Women, Layton Reesor-Oyer, Nadia Garcia Marroquin, Daphne C. Hernandez

Health Behavior Research

Food insecurity is related to overweight/obesity among women. However, it is unknown whether food insecurity impacts individuals’ desired body composition, and whether this relationship differs by race/ethnicity similar to perceived ideal weight status. This study aims to evaluate whether food insecurity is related to elevated preferred weight status (e.g., overweight/obese versus normal weight) among black, white, and Hispanic women classified as overweight/obese. Four waves of NHANES data (2007–2014) were merged and yielded a total of 907 black, 1,271 white, and 1,005 Hispanic non-pregnant adult (age 20 to 59) women classified as overweight/obese. Participants self-reported their preferred weight status, adult-level food …

Association Between Obesity And Hormone Receptor Characteristics Of Primary Breast Cancer At Cipto Mangunkusumo General Hospital, Jakarta, In 2017, Hardian Gunardi, Diani Kartini

The New Ropanasuri Journal of Surgery

Introduction. Obesity is an independent risk factor and prognostic factor of primary breast cancer. Abundant adipose tissue would lead to increment of blood estrogen level; thus, promoting proliferation of cancer cell, especially those with positive estrogen receptor (ER) and progesterone receptor (PR). No study reported the association between obesity and hormone receptor characteristics of primary breast cancer in Indonesia.

Method. We collected cases of primary breast cancer which is diagnosed and undergone immunohistochemistry examination at Cipto Mangunkusumo General Hospital in 2017. The subjects divided into obese group and non-obese group. The ER and PR characteristics of both groups were compared …

Association Between Obesity And History Of Atopy With Atopic Dermatitis In Children: A Cross-Sectional Study, Putu Nila Wardhani Batan, Ariana Ariana, Made Wardhana

Journal of General - Procedural Dermatology & Venereology Indonesia

Background: The prevalence of atopic dermatitis (AD) has rapidly increased in the past 4 decades and has been mostly observed in children. The prevalence of obesity has also significantly increased worldwide, suggesting that the two conditions may be associated.

Methods: This retrospective analytic study involved a cross-sectional design and used secondary data taken from the medical record of patients who visited the Pediatric Dermatology Subdivision at Dermatology and Venereology Polyclinic Sanglah General Hospital from January 2015 to December 2015. Thirty-two samples were selected.

Results: The prevalence ratio of obesity among subjects with AD was 2.178 (95% CI …

A Culturally Competent Phenotypic Evaluation / Obesity Assessment In African And African American Populations: Pilot Study, Catrina Johnson, Robert Corrucini, Daniel Beque, Wanki Moon, Kola Ajuwon, David A. Lightfoot

Articles

BMI, a ratio of weight over height, is a culturally-biased tool imposed upon the scientific, academic and medical communities as an errant measure of obesity across ethnic - ity. Body Mass Index (BMI) relates mass (g) to a relative fat distribution with regards to height. Its genesis is from the actuarially derived and ethnically exclusive height and weight tables that promote the fictional notion of inter-eth - nic ideal weights that would be later adopted by the Na - tional Institutes of Health (NIH) as a competent measure of adiposity. Best practice, movement towards individualized medicine and deployment of effective …

Precarity Beyond Food: How The Closure Of An Independent Grocery Store Shed Light On The Limitations Of Food Access Efforts In Syracuse, New York, Katherine Louisa Ravene Mott

Theses - ALL

On September 11, 2017, the owner of an independent grocery store in Syracuse, New York’s Near Westside neighborhood announced that the store would close within the month. The Near Westside is often characterized by its high levels of concentrated poverty for African American and Hispanic neighborhood residents. Nojaim Brothers Supermarket opened in 1919 and persisted for 97 years amidst an unfavorable political and economic landscape marked by the creation of both chain grocery stores and supermarkets as well as the effects of urban renewal and disinvestment. I argue that Nojaim’s endurance can be attributed to the embeddedness of the grocery …

Effect Of Metformin On Adolescent Obesity, Mackenzie Mcnamee, Victoriya Eggen

Physician Assistant Capstones, 2016 to 2019

Objectives: Metformin is the first line treatment for type 2 diabetes mellitus (T2DM) in both adults and children and has been shown to result in weight loss. Pediatric obesity is a major risk factor for the development of T2DM as well as several other diseases. Recently, physicians have reported using Metformin off-label to treat obesity in adolescent patients. The purpose of this study is to investigate whether Metformin is effective in reducing BMI in obese adolescents.

Methods: Studies were found using PubMed, MeSH, Medline, and CINAHL. The search terms used were: “obesity,” Metformin,” “adolescents,” “children,” “metformin and weight,” …

Vegetable, Dietary Fiber Consumption And Obesity In Japan And The United States, Megumi Hashida

Theses and Dissertations

The US and Japanese populations do not meet recommended DF intakes. This study indicated the relationship between the variety of vegetables available in markets and vegetable consumption in the US and Japan. The number of vegetables available in markets was determined using online resources from five markets in each country. Mean number of vegetable products in the US was 104.4 products (SD: ±36.8) and mean number of vegetable products in the Japanese markets was 120.2 products (SD: ±15.6). There was no significant relationship between the variety of vegetables in markets and vegetable consumption between the US and Japan. This study …

Perceptions Of Food, Supportive Resistance Resources, And Nutrition Knowledge Of Bariatric Surgery Patients, Savannah K. Walker

Theses and Dissertations

Adult overweight and obesity is a life-threatening health concern worldwide. Bariatric surgery is a successful treatment for severely obese individuals however, there is a moderate risk for weight regain. This study evaluated perception of food, supportive resistance resources, and nutrition knowledge, which play important roles in successful weight loss post bariatric surgery. Participants completed a three-part questionnaire at three time intervals: prior to surgery, 2 months post-surgery, and 5 months post-surgery. Results show that bariatric patients’ eating behavior significantly changes post bariatric surgery, but a disordered perception of food remains. Bariatric surgery patients believe support from significant others and family …

The Effects Of Lifestyle And/Or Vitamin D Supplementation Interventions On Pregnancy Outcomes: What Have We Learned From The Dali Studies?, Jürgen Harreiter, Gernot Desoye, Mireille N.M. Van Poppel, Alexandra Kautzky-Willer, Fidelma Dunne, Rosa Corcoy, Roland Devlieger, David Simmons, Juan M. Moore, Eileen K. Hutton

Paediatrics Publications

Purpose of Review: The DALI (vitamin D and lifestyle intervention in the prevention of gestational diabetes mellitus (GDM)) study aimed to prevent GDM with lifestyle interventions or Vitamin D supplementation (1600 IU/day). This review summarizes the learnings from the DALI studies among pregnant women with a BMI ≥ 29 kg/m2. Recent Findings: Women diagnosed with GDM earlier in pregnancy had a worse metabolic profile than those diagnosed later. A combined physical activity (PA) and healthy eating (HE) lifestyle intervention improved both behaviours, limited gestational weight gain (GWG) and was cost-effective. Although GDM risk was unchanged, neonatal adiposity was reduced due …

Feasibility And Acceptability Of A Rural, Pragmatic, Telemedicine‐ Delivered Healthy Lifestyle Programme, John A. Batsis, Auden C. Mcclure, Aaron B. Weintraub, David F. Kotz, Sivan Rotenberg, Summer B. Cook, Diane Gilbert-Diamond, Kevin Curtis, Courtney J. Stevens, Diane Sette, Richard I. Rothstein

Dartmouth Scholarship

Background: The public health crisis of obesity leads to increasing morbidity that are even more profound in certain populations such as rural adults. Live, two‐way video‐conferencing is a modality that can potentially surmount geographic barriers and staffing shortages. Methods: Patients from the Dartmouth‐Hitchcock Weight and Wellness Center were recruited into a pragmatic, single‐arm, nonrandomized study of a remotely delivered 16‐week evidence‐based healthy lifestyle programme. Patients were provided hardware and appropriate software allowing for remote participation in all sessions, outside of the clinic setting. Our primary outcomes were feasibility and acceptability of the telemedicine intervention, as well as potential effectiveness on …

Zyflamend Inhibits Adipogenesis: A Mechanistic Study Evaluating The Impact Of Phytonutrients On Adipocyte Differentiation, Victoria Frankel

Masters Theses

Zyflamend, a polyphenol herbal supplement, includes numerous different extracts. This botanical complex has been used as a natural anti-inflammatory due to its impact on COX-2. More recently, research has exhibited its potential as an anti-cancer agent. Currently, the effects of Zyflamend in non-cancer cells, specifically adipocytes, has yet to be explored. Due to Zyflamend's ability to promote activation of AMPK, it may prove relevant to study the potential interactions with cells treated with Zyflamend during differentiation, a metabolically involved process. This study sought to determine the impact of Zyflamend on non- cancer cells such as 3T3-L1 adipocytes during differentiation and …

Genetic Determinants Of Variation In The Gh/Igf-1 Axis And Their Relationship To Cardiometabolic Health, Rafael Luis Aguirre Guillen

Theses and Dissertations

Background: In a study of Mexican Americans, we performed analyses of GEI and pleiotropy in the axis in relation to MS. GH/IGF-1 axis components were studied. Model parameters and likelihoods were estimated by maximum likelihood.

Results: Pleiotropy was observed for IGFBP3 (p

Conclusions: IGF-I and IGFBP3 are genetically correlated with MS whereas MS influences the additive genetic variance in IGFBP1 variables mainly but also in IGF-I somewhat by virtue of the VH exhibited by IGF-I/IGFBP1.

The Epidemiological Burden Of Obesity In Childhood: A Worldwide Epidemic Requiring Urgent Action, Mariachiara Di Cesare, Maroje Sorić, Pascal Bovet, J Jaime Miranda, Zulfiqar Ahmed Bhutta, Gretchen A. Stevens, Avula Laxmaiah, Andre-Pascal Kengne, James Bentham

Department of Paediatrics and Child Health

Background: In recent decades, the prevalence of obesity in children has increased dramatically. This worldwide epidemic has important consequences, including psychiatric, psychological and psychosocial disorders in childhood and increased risk of developing non-communicable diseases (NCDs) later in life. Treatment of obesity is difficult and children with excess weight are likely to become adults with obesity. These trends have led member states of the World Health Organization (WHO) to endorse a target of no increase in obesity in childhood by 2025.
Main body: Estimates of overweight in children aged under 5 years are available jointly from the United Nations Children's Fund …

Physical Activity Level And Insulin Resistance In 6,500 Nhanes Adults: The Role Of Abdominal Obesity, James R Fowler

Theses and Dissertations

OBJECTIVE: This cross-sectional study investigated insulin resistance (IR) variation across physical activity (PA) levels in U.S. adults. METHODS: MET-minutes were utilized to quantify PA using 2 methods: 4 categories were based on relative MET-minutes, and 5 were based on U.S. PA guidelines. IR was indexed using the homeostatic model assessment (HOMA). Effect modification was tested by dividing waist circumferences into sex-specific quartiles, and then evaluating the relationship between PA and HOMA-IR within each quartile separately. RESULTS: Relative PA was associated with HOMA-IR after controlling for demographic and demographic and lifestyle covariates (F = 11.5, P < 0.0001 and F = 6.0, P = 0.0012, respectively). Adjusting for demographic and demographic and lifestyle covariates also revealed relationships between guideline-based PA and HOMA-IR (F = 8.0, P < 0.0001 and F = 4.9, P = 0.0017, respectively). Controlling for waist circumference with the other covariates nullified the relationship between PA and HOMA-IR. Effect modification testing showed that when the sample was delimited to adults with extra-large waists (Quartile 4), relative (F = 5.6, P = 0.0019), and guideline-based PA (F = 3.7, P = 0.0098) and HOMA-IR were related. PA and HOMA-IR were not related within the other quartiles. CONCLUSION: High levels of PA may play a meaningful role in glucose and insulin metabolism in those with abdominal obesity, but not in adults with smaller waists.

Adapting The Diabetes Prevention Program For Low And Middle-Income Countries: Protocol For A Cluster Randomised Trial To Evaluate 'Lifestyle Africa'., Delwyn Catley, Thandi Puoane, Lungiswa Tsolekile, Ken Resnicow, Kandace Fleming, Emily A. Hurley, Joshua M. Smyth, Mara Z. Vitolins, Estelle V. Lambert, Naomi Levitt, Kathy Goggin

Manuscripts, Articles, Book Chapters and Other Papers

Introduction: Low and middle-income countries like South Africa are experiencing major increases in burden of non-communicable diseases such as diabetes and cardiovascular conditions. However, evidence-based interventions to address behavioural factors related to these diseases are lacking. Our study aims to adapt the CDC's National Diabetes Prevention Program (DPP) within the context of an under-resourced urban community in Cape Town, South Africa.

Methods/analysis: The new intervention (Lifestyle Africa) consists of 17 weekly sessions delivered by trained community health workers (CHWs). In addition to educational and cultural adaptations of DPP content, the programme adds novel components of text messaging and …

Genetic Vulnerability To Diabetes And Obesity: Does Education Offset The Risk?, Sze Yan Liu, Stefan Walter, Jessica Daniel, David H. Rehkopf, Laura E. Kubzansky, M Maria Glymour

Sze Yan Liu

The prevalence of type 2 diabetes (T2D) and obesity has recently increased dramatically. These common diseases are likely to arise from the interaction of multiple genetic, socio-demographic and environmental risk factors. While previous research has found genetic risk and education to be strong predictors of these diseases, few studies to date have examined their joint effects. This study investigates whether education modifies the association between genetic background and risk for type 2 diabetes (T2D) and obesity. Using data from non-Hispanic Whites in the Health and Retirement Study (HRS, n = 8398), we tested whether education modifies genetic risk for obesity …

Obesity And Insulin Sensitivity Effects On Cardiovascular Risk Factors: Comparisons Of Obese Dysglycemic Youth And Adults, David A. Ehrmann, Karla A. Temple, Abby Rue, Elena Barengolts, Babak Mokhlesi, Eve Van Cauter, Susan Sam, M. Annette Miller

Paediatrics Publications

Background: Obesity and pubertal insulin resistance worsen cardiovascular (CV) risk factors in youth. It is unclear how the relationships of obesity and insulin resistance with CV risk compare to adults. Subjects and Methods: We evaluated 66 pubertal youth (mean ± SD: age 14.2 ± 2.0 years, body mass index [BMI] 36.6 ± 6.0 kg/m2, hemoglobin A1c [HbA1c] 38.5 ± 6.1 mmol/mol) and 355 adults with comparable BMI (age 52.7 ± 9.4 years, BMI 35.1 ± 5.1 kg/m2, HbA1c 39.8 ± 4.2 mmol/mol) participating in a multicenter study. Insulin sensitivity was quantified using hyperglycemic clamps. Assessment of CV risk factors was …

Life On Holidays: Study Protocol For A 3-Year Longitudinal Study Tracking Changes In Children's Fitness And Fatness During The In-School Versus Summer Holiday Period, Amanda Watson, Carol Maher, Grant R. Tomkinson, Rebecca Golley, Francois Fraysse, Dorothea Dumuid, Hayley Lewthwaite, Tim Olds

Education, Health & Behavior Studies Faculty Publications

Background: Emerging evidence suggests that children become fatter and less fit over the summer holidays but get leaner and fitter during the in-school period. This could be due to differences in diet and time use between these distinct periods. Few studies have tracked diet and time use across the summer holidays. This study will measure rates of change in fatness and fitness of children, initially in Grade 4 (age 9 years) across three successive years and relate these changes to changes in diet and time use between in-school and summer holiday periods.

Methods: Grade 4 Children attending Australian Government, Catholic …

Contrasting Adult And Emerging Adult Women On Possible Psychosocial And Behavioral Correlates Of Short-Term Weight Loss, James J. Annesi, Ping H. Johnson

Health Behavior Research

Physical activity could be associated with psychosocial correlates of changes in eating behaviors required for weight loss. This field investigation assessed relationships of physical activity with early changes in psychosocial variables such as depression, fatigue, and body satisfaction; and their effect on fruit/vegetable and sweets intake and weight change. Emerging adult women from a university setting (M_age = 20.4 years, SD = 2.0; n = 36) and adult women from a community health-promotion setting (M_age = 45.6 years, SD = 7.3; n = 36), participating in the same cognitive-behavioral weight-loss program that initiated physical activity prior …

Bidirectional Associations Between Obesity And Cognitive Function In Midlife Adults: A Longitudinal Study, Andree Hartanto, Jose C. Yong, Wei Xing Toh

Research Collection School of Social Sciences

The links between obesity and cognition remain equivocal due to a variety of methodological limitations with current research, such as an overreliance on body mass index (BMI) as a measure of obesity, the use of cross-sectional designs, and inadequate specification over the domains of cognitive function to be examined. To address these issues, we used data from the Cognitive Project of the National Survey of Midlife Development in the United States, a large-scale, longitudinal dataset on non-institutionalized midlife adults (N = 2652), which enabled us to examine the long-term bidirectional relations between obesity and two latent factors of cognition—executive function …

Gender-Specific Differences In Clinical And Metabolic Variables Associated With Nafld In A Mexican Pediatric Population, Eréndira Villanueva-Ortega, María José Garcés-Hernández, Arturo Herrera-Rosas, Juan Carlos Lopez Alvarenga, Estibalitz Laresgoiti-Servitje, Galileo Escobedo, Gloria Queipo, Sergio Cuevas-Covarrubias, Guadalupe Nayely Garibay-Nieto

School of Medicine Publications and Presentations

Introduction and objectives: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in children and it is more prevalent in Hispanic males. The gender differences can be explained by body fat distribution, lifestyle, or sex hormone metabolism. We evaluated anthropometric and metabolic differences by gender in children with and without NAFLD.

Methods: We included 194 participants (eutrophic, overweight, and individuals with obesity). The presence of NAFLD was determined using ultrasonography, and we evaluated the association between this disease with metabolic and anthropometric variables by gender.

Results: The mean age was 10.64±2.54 years. The frequency of NAFLD in boys …

A Quality Improvement Project To Determine The Incidence And Prevalence Of Obstructive Sleep Apnea, Best Practice Anesthesia Guidelines, And The Incidence Of Perioperative Cardiac And Respiratory Complications After The Implementation Of The Stop-Bang Questionnaire, Bradly Diamond, Gregory Guerrier, Cody Holliman, Robert Marrero, Tyler Nelson

Doctoral Projects

Patients with obstructive sleep apnea (OSA) are at risk for perioperative respiratory and cardiovascular compromise (Opperer et al., 2016). Unfortunately, almost 90% of patients with moderate-to-severe OSA are not diagnosed and unaware of their disorder; however, they remain at increased perioperative risks (Singh et al., 2015). The STOP-BANG questionnaire was developed to meet the need for a reliable, concise, and efficient screening tool for OSA risk. The facility at which this project was conducted did not utilize a prescreening OSA risk tool. The facility not using a prescreening OSA risk tool is especially important because the State of Mississippi currently …

Health Care Access By Weight Status In The State Of Georgia, Elizabeth Pullekines, Janani Rajbhandari-Thapa

Journal of the Georgia Public Health Association

Background: Obesity continues to grow in prevalence in the United States and within the state of Georgia. Obesity is a risk factor for many chronic and preventable diseases. As such, obese individuals have higher demand for health care services than non-obese individuals. In addition, the health care system can play a role in preventing obesity and other conditions caused by obesity.

Methods: This research follows the established positive relationship between health care use and access to health care services through insurance coverage. The paper analyzes how the Affordable Care Act (ACA) affected insurance coverage and access to health care services …

Sociodemographic And Biometric Factors Associated With Eating Behaviors Among African American Women Aged 18-74, Takiyah J. Thomas, Jammie M. Hopkins, Riba Kelsey-Harris, Folashade Omole, Ernest Alema-Mensah

Journal of the Georgia Public Health Association

Background: Obesity is a growing problem in the United States and is disproportionately increasing among African Americans. The objective of this study is to examine the sociodemographic and biometric factors associated with eating behaviors among African American women.

Methods: We analyzed data from the 2009-2010 dietary screener and weight history questionnaire from the National Health and Nutrition Examination Survey. Multivariable analyses were used to estimate adjusted odds ratios (AORs) and 95% confidence intervals (95% CIs) to determine the association between six specific eating behaviors and different sociodemographic and biometric factors. Analyses were conducted using SAS 9.4.

Results: The analyses show …

Extreme Obesity Among Adults In The United States: Spatial Variation And The Association With Mortality, Carrie Mills

Dissertations and Theses

Objectives: The purpose of this dissertation was to create small area estimates to describe and explore the county-level spatial variation of extreme obesity among adults in the United States and to assess the county-level association and spatial variation of extreme obesity and mortality.

Methods: The Behavioral Risk Factor Surveillance System was used in conjunction with data from the Census Bureau to estimate county-level model-predicted prevalence of extreme obesity using multilevel regression and poststratification. Spatial dependence of estimates was assessed using global Moran’s Index, and local Moran’s Indices were used to identify clusters of higher and lower rates of extreme obesity …

Prevalence Of Overweight And Obesity And Their Associations With Dietary Habits Among Students From A Major University In Palestine: A Cross-Sectional Study, Bassam Abu Shanab, Haleama Al-Sabbah

Palestinian Medical and Pharmaceutical Journal

Overweight and obesity are major public health problems and the most common nutri-tional disorders. The prevalence of overweight and obesity is rising at an alarming rate in both developing and developed countries. This study aimed to assess the prevalence of overweight and obesity and their associations with dietary habits among students from a major university in Palestine. A cross-sectional study was conducted on 304 Students (50% males and 50% females). Students were asked to fill in a standard questionnaire. Weight, height, and waist circumference were measured and hemoglobin level was tested. Statistical analysis was con-ducted using SPSS version 15.0. The …

Prevalence And Correlates Of Cardiometabolic Multimorbidity Among Hypertensive Individuals: A Cross-Sectional Study In Rural South Asia—Bangladesh, Pakistan And Sri Lanka, Liang Feng, Imtiaz Jehan, H Asita De Silva, Aliya Naheed, Hamida Farazdaq, Samina Hirani Samina Hirani, Anuradhani Kasturiratne, Channa D. Ranasinha, Md Tauhidul Islam, Ali Tanweer Siddiquee, Tazeen Jafar

Community Health Sciences

Objective: To determinate the prevalence and correlates of cardiometabolic multimorbidity (CMM), and their cross-country variation among individuals with hypertension residing in rural communities in South Asia.
Design: A cross-sectional study.
Setting: Rural communities in Bangladesh, Pakistan and Sri Lanka.
Participants: A total of 2288 individuals with hypertension aged ≥40 years from the ongoing Control of Blood Pressure and Risk Attenuation- Bangladesh, Pakistan and Sri Lanka clinical trial.
Main outcome measures: CMM was defined as the presence of ≥2 of the conditions: diabetes, chronic kidney disease, heart disease and stroke. Logistic regression was done to evaluate the correlates of CMM.
Results: …

Colostrum And Mature Breast Milk Analysis Of Serum Irisin And Sterol Regulatory Element-Binding Proteins-1c In Gestational Diabetes Mellitus, Syeda Sadia Fatima, Erum Khalid, Asma Akbar Ladak, Syed Adnan Ali

Department of Biological & Biomedical Sciences

Background: We aimed to evaluate irisin and SREBP-1c levels in serum, colostrum and mature breast milk in women with and without gestational diabetes (GDM); and to relate them with maternal glucose, lipid profile and weight status of babies.
Methods: GDM positive women (n = 33) and normal glucose tolerant women (NGT) (n = 33) were recruited. Maternal blood samples were collected at 28th week of gestation and later at 6-week post-partum while breast milk samples of the lactating mothers were collected within 72 hours of birth (colostrum) and at 6 weeks post-partum (mature milk). Irisin and SREBP-1c levels were analyzed …

Diet Quality And Micronutrient Intake In Long-Term Weight Loss Maintainers, Rebecca W. Pascual

Master's Theses

Objective: This study’s purpose was to examine dietary quality, macronutrient intake, and micronutrient adequacy among long term weight loss maintainers (WLM) in a commercial weight management program.

Methods: Participants were 1,207 WLM in WW (formerly Weight Watchers) who had maintained a 9.1 kg or greater weight loss (29.7 kg on average) for 3.4 years, and had an average BMI of 28.3 kg/m². A control group of weight stable adults with obesity (Controls; N=102) had a BMI of 41.1 kg/m² and 2.3 kg or less weight change over the previous five years.

Results: WLM vs. …

Nobiletin Corrects Intestinal Insulin Resistance And Lipid Metabolism In Ldlr-/- Mice Fed A High-Fat Diet, Nadya Morrow

Electronic Thesis and Dissertation Repository

The citrus flavonoid nobiletin has lipid lowering and insulin-sensitizing properties. In mice, nobiletin supplementation prevents high fat diet-induced dyslipidemia and insulin resistance. Interestingly, triglyceride mass remains elevated in the intestine of fasted high fat-fed mice, but not in nobiletin-supplemented mice. In this thesis, the mechanisms underlying the prevention of intestinal triglyceride retention by nobiletin were investigated. In male Ldlr^-/- mice, nobiletin corrected intestinal insulin signaling resulting in normalization of de novo lipogenesis and decreased triglyceride for chylomicron synthesis and storage. In response to an oral fat load, nobiletin increased chylomicron-triglyceride secretion into plasma and enhanced plasma triglyceride clearance resulting …