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Non-Invasive Hyperglycemia Detection Using Ecg And Deep Learning, Renato Silveira Cordeiro

Master's Theses

Hyperglycemia is characterized by an elevated level of glucose in the blood. It is normally asymptomatic, except for an extremely high level, and thus a person can live in that state for years before the negative - sometimes irreversible - health impacts appear. Unexpected hyperglycemia can also be an indication of diabetes, a chronic disease that, when not treated, can lead to serious consequences, including limb amputations and even death. Therefore, identifying hyperglycemic state is important. The most common and direct way to measure a person’s glucose level is by directly assessing it from a blood sample by pricking a …

Fda Approves New Inhaled Insulin: Afrezza® (Technosphere® Insulin), Benjamin Finley, Christina Ciccone, Kimberly Loughlin, Michelle Musser

Pharmacy and Wellness Review

Diabetes is an endocrine disease caused by deficiency or malfunction of insulin that results in high blood glucose levels and places patients at higher risk for a number of complications. This chronic disease is difficult to manage and affects millions of people in the United States, costing the health care system billions of dollars a year. Of a variety of antidiabetic agents used to control blood glucose, insulin is perhaps the most effective, but until recently it was only available in injectable form. As of June 27, 2014, a new inhaled insulin called Afrezza® (Technosphere® insulin) was approved by the …

Nurses' Level Of Comfort, Familiarity, And Knowledge About Diabetes Management In Vinmec Central Park International Hospital, Nguyen Thi Xuan Mai

Master's Theses

Clinical nurses have a key role in supporting and management of diabetes patients during hospitalization. The purpose of this study was to evaluate nurses’ level of comfort, familiarity, and knowledge in diabetes management. In this study, 30 full-time nurses working in Vinmec Central Park International Hospital completed a 34-question assessment that included eight questions on comfort, six questions on familiarity, and 20 questions on nursing knowledge. The findings indicated the level of nursing knowledge regarding diabetes management in the hospital was low. The comfort, familiarity, and knowledge scores were not directly proportional to the age, education, and years of clinical …

The Relationship Between Continuous Glucose Monitor (Cgm) Derived Metrics And Indices Of Glycemic Control, Ryan Bailey

USF Tampa Graduate Theses and Dissertations

Introduction: Both hypoglycemia (low blood glucose) and hyperglycemia (high blood glucose) are common among individuals with type 1 diabetes and are associated with severe medical complications, therefore it is essential that health care providers are able to accurately measure glycemic control. Measures derived from continuous glucose monitoring (CGM) may provide more accurate measurements of glycemia than the commonly used HbA1c blood test.

Methods: Data from the Juvenile Diabetes Research Foundation (JDRF) clinical trial to assess the efficacy of continuous glucose monitoring was used to estimate the ability of CGM composite scores to predict time in range, time in hyperglycemia and …

Advanced Glycation End Products: Formation, Role In Diabetic Complications, And Potential In Clinical Application, Rujman Khan, Xin Yee Ooi, Matthew N. Parvus, Laura Valdez, Andrew Tsin

School of Medicine Publications and Presentations

Hyperglycemic conditions and disruptions to glucose-regulating pathways lead to increased formation of highly reactive aldehydes, methylglyoxal and glyoxal, which react with certain arginine and lysine residues in proteins to form advanced glycation end products (AGEs). These AGEs damage the integrity of the retinal vasculature predominantly through two mechanisms: non-receptor-mediated damage, which pertains to the interaction with extracellular matrix and its functional properties, and receptor-mediated damage through AGE interactions with their receptors (RAGE) on pericytes and Muller cells. Damage occurring between AGE and RAGE potentially generates reactive oxygen species, inflammatory cytokines, and growth factors. Both mechanisms result in increased permeability of …

Long-Term Safety And Efficacy Of Subcutaneous Pasireotide In Patients With Cushing's Disease: Interim Results From A Long-Term Real-World Evidence Study., Luca Manetti, Timo Deutschbein, Jochen Schopohl, Kevin C J Yuen, Michael Roughton, Ulrike Kriemler-Krahn, Libuse Tauchmanova, Ricardo Maamari, Carla Giordano

Neurology

PURPOSE: Clinical trials have demonstrated the favorable efficacy/safety profile of pasireotide in patients with Cushing's disease (CD). We report interim long-term results of an ongoing real-world evidence study of subcutaneous pasireotide in patients with CD.

METHODS: Adults with CD receiving pasireotide, initiated before (prior-use) or at study entry (new-use), were monitored for ≤ 3 years during a multicenter observational study ( http://clinicaltrials.gov identifier NCT02310269). Primary objective was to assess long-term safety of pasireotide alone or with other CD therapies.

RESULTS: At the time of this interim analysis, 127 patients had received pasireotide (new-use, n = 31; prior-use, n = 96). …

Long-Term Safety And Efficacy Of Subcutaneous Pasireotide In Patients With Cushing's Disease: Interim Results From A Long-Term Real-World Evidence Study., Luca Manetti, Timo Deutschbein, Jochen Schopohl, Kevin C J Yuen, Michael Roughton, Ulrike Kriemler-Krahn, Libuse Tauchmanova, Ricardo Maamari, Carla Giordano

Articles, Abstracts, and Reports

PURPOSE: Clinical trials have demonstrated the favorable efficacy/safety profile of pasireotide in patients with Cushing's disease (CD). We report interim long-term results of an ongoing real-world evidence study of subcutaneous pasireotide in patients with CD.

METHODS: Adults with CD receiving pasireotide, initiated before (prior-use) or at study entry (new-use), were monitored for ≤ 3 years during a multicenter observational study ( http://clinicaltrials.gov identifier NCT02310269). Primary objective was to assess long-term safety of pasireotide alone or with other CD therapies.

RESULTS: At the time of this interim analysis, 127 patients had received pasireotide (new-use, n = 31; prior-use, n = 96). …

Type Ii Diabetes Mellitus, Marie Bertke

Nursing Student Class Projects (Formerly MSN)

Type II Diabetes Mellitus (DMII) is a metabolic disorder that affects glucose metabolism. Characteristics of DMII include: hyperglycemia, insulin resistance, and impaired insulin secretion by the pancreas. Contributing risk factors in the development of DMII includes: familial history of diabetes, obesity, physical inactivity, hypertension, and other comorbid medical conditions. Signs and symptoms of DMII include: polyuria, polydipsia, fatigue, weight loss, blurry vision, as well as, other long-term complications. The complex pathophysiology of DMII will be discussed in this poster, as well as the diagnosis and treatment of DMII. Greater discussion and education is needed for healthcare providers with the increase …

Type 2 Diabetes (T2d), Janice Loney

Nursing Student Class Projects (Formerly MSN)

ABSTRACT

Type 2 diabetes (T2D) is a devastating disease predisposing individuals to a myriad of serious health complications such as: heart disease, stroke, retinopathy, neuropathy, renal disease, dementia, amputation and early death. Diabetes care has a major economic impact worldwide, as a future family nurse practitioner (FNP) patient education on T2D risk factors, disease process and medical management are vital to halt this growing epidemic. A literature search was conducted and five peer reviewed articles were chosen addressing T2D pathophysiology, risk factors, effects of self-care behaviors and emerging treatment options.

Focused efforts from the literature reviews indicate education and adherence …

Effects Of Perioperative Hyperglycemia In Patients With Diabetes Compared To Patients Without Diabetes: A Retrospective Study Of Treatment And Outcomes, Matthew Anderson

Capstone Experience

The main goal of this project was to examine the differences in perioperative hyperglycemia treatment received by patients with a diagnosis of diabetes mellitus (DM) and patients without a diagnosis of diabetes (NDM); and how these treatment differences can affect the length of hospital stay. Studies have revealed that, when comparing DM and NDM patients with the same degree of perioperative hyperglycemia, NDM patients suffer worse outcomes. It has been suggested in previous research that this may be because NDM patients receive treatment that does not measure up to the standard of care treatment that DM patients receive. In this …