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Role Of The Endocannabinoid System And Medical Cannabis, Sabrina Jarvis, Sean Rasmussen, Blaine Winters

Student Works

Our bodies produce substances called endocannabinoids which attach to receptors within the endocannabinoid system (ECS) impacting physiological processes on a daily basis. The cannabis plant contains over 100 different cannabinoids which also manipulate the ECS. Knowledge about these interactions have led to an increase in cannabis based pharmacological studies. Providers should have a basic understanding about how the ECS works and how cannabis is being used to treat certain illnesses. This article presents what is currently known about the ECS and how cannabis based medicines impact it, as well as the current laws providers need know regarding cannabis use.

Very Rapid Onset Cannabis Dependence Risk In Relation To Co-Occurring Use Of Other Psychoactive Drugs, Olga A. Vsevolozhskaya, Fernando A. Wagner, James C. Anthony

Biostatistics Presentations

Background: Epidemiological estimates for lifetime cumulative incidence indicate that for every 9-11 who start using cannabis, one becomes a case of the cannabis dependence syndrome (CDS) – i.e., roughly 9%-11%. More recent estimates clarify that CDS risk might be much lower among ’cannabis only’ users, due in part to the fact that many ’cannabis only’ users try the drug a few times and never again. We turned to Hill functional analysis in order to study CDS probability soon after 1st cannabis use, estimated across strata defined by the number of recent days of cannabis use, with an acknowledgment that a …

Potholes: Dui Law In The Budding Marijuana Industry, Zack G. Goldberg

Brooklyn Law Review

The rapid legalization of marijuana across the United States has produced a number of novel legal issues. One of the most confounding issues is that presented by the marijuana-impaired driver. In jurisdictions that have legalized the use of marijuana, how high is too high to get behind the wheel? This note assesses the various marijuana DUI laws that states have implemented to combat marijuana-impaired driving. Many of these statutes have followed in the footsteps of the BAC-based standard used to combat drunk driving—using THC measurements to quantify a driver’s level of marijuana-based impairment. Unfortunately, unlike alcohol, the scientific properties of …

Pharmacology Of Cannabis, Mandakini Sadhir

Pediatrics Faculty Publications

Cannabis has been used for recreational purposes around the world. It is derived from the plant cannabis sativa which has various other compounds known as cannabinoids. Most common form of cannabis used for recreational purpose is marijuana, which is prepared from dried flowering tops and leaves. The primary psychoactive component is delta 9-tetrahydrocannabinol (δ-9THC), which exerts its physiological and psychological effects through its interaction with CB1 and CB2 receptors. Smoking is the most commonly used method with onset of effects within minutes after inhalation. Oral ingestion of cannabis has varied absorption with delayed onset but longer duration of action. Urine …

Effects Of The Legalization Of Recreational Cannabis In Washington State, John Anthony Poore

Global Honors Theses

The War on Drugs has failed. The criminalization of the use of recreational marijuana has not led to a reduction in use. This paper argues that policy surrounding recreational cannabis should observe existing policies such as legalization with regulations or decriminalization in order to increase public health and reduce government expenditures from the enforcement of criminal penalties for cannabis use. The existing literature suggests that these methods help to reduce harmful drug use, illegal sales and drug related crime. Experts in the areas of public health, criminal justice, cannabis policy and the cannabis industry were interviewed for the purpose of …

Cannabis In Palliative And Hospice Medicine, Leanna J. Standish Nd, Phd

Palliative Care Institute

At the end of this session, participants will be able to:

1. Identify the appropriate uses of cannabis and psychedelics in the treatment of pain and end of life symptoms
2. Define the concerns and legal challenges of integrating this complementary therapy with traditional treatments

Education About The Adverse Health Effects Of Recreational Marijuana: The Role Of Type Of Persuasion And Source, Dina Mattern

Seton Hall University Dissertations and Theses (ETDs)

In recent years, efforts have been made to legalize cannabis based on increasing research supporting medical benefits and the assumption, albeit questionable, that this is a safe drug. Statistics from the National Institute on Drug Abuse (NIDA) demonstrate a sharp increase in users, especially among the youth population (2014). This is problematic because smoking marijuana during the teenage years has been shown to have possible adverse effects, such as despondency and potential complications in cognitive development. (Crane et al., 2012) This current study aims to explore effective ways to educate the public on the adverse health effects of recreational marijuana …

Early Onset Marijuana Use And Adult Mental Health, Christine Murphy Andrews

Public Health Theses

INTRODUCTION: The impact of marijuana use has become a national topic with the increase in state’s legalizing or decriminalizing the use of the drug. To understand the impact this new trend may have on the population, it is necessary to characterize the interaction between marijuana use and health outcomes. Previous research has focused on the acute effects of marijuana on mental health and longitudinal impacts of marijuana use in the adolescent population. However there are no previously published studies on the impact of early onset marijuana use on adult mental health.

AIM: This study aims to determine the prevalence of …

Cannabis Use And Affective Processing: A Brain Structure Analysis, Kristin E. Maple

Theses and Dissertations

Cannabis is the most commonly used illicit drug amongst adolescents and young adults in the United States. Previously, cannabis and its components have been associated with differences in affective processing and neural functioning. Participants (ages 16-25) were cannabis users and non-users excluded for psychiatric disorders, major medical conditions, and excessive other drug use. A series of multiple regressions examined whether past year cannabis use and cannabis x gender predicted measures of emotional face processing (using the PennCNP affective battery) as well as volumes in bilateral prefrontal, temporal, limbic, and cerebellar regions, as well as frontolimbic white matter tracts. Subsequently, Pearson …

Patenting Marijuana Strains: Baking Up Patent Protection For Growers In The Legal Fog Of This Budding Industry, Joseph Dylan Summer

Journal of Intellectual Property Law

No abstract provided.

The Influence Of Doctoral Psychology Trainees' Personal Cannabis Use, Perceptions Of Cannabis' Risks, And Attitudes Toward Substance Use On Ability To Identify Cannabis Use Disorder, Alexandra G. Stratyner

Seton Hall University Dissertations and Theses (ETDs)

The incidence of cannabis use disorder is increasing across the United States as a function of increased cannabis use (Hasin et al., 2015); accordingly, it is critical that mental healthcare professionals be able to accurately identify cannabis use disorder. In light of this imperative, the current study explored potential barriers to diagnosing cannabis use disorder among doctoral psychology trainees. Participants (N = 123) were doctoral students in clinical psychology, counseling psychology, and related disciplines. Utilizing a quasi-experimental analogue design, the study examined whether doctoral psychology trainees’ personal cannabis use predicted their perceptions of the risks of cannabis use and …

Newsroom: Horwitz On Legalizing Marijuana 04-10-2016, Andrew Horwitz, Peter Kilmartin

Life of the Law School (1993- )

No abstract provided.

Underbanked: Cooperative Banking As A Potential Solution To The Marijuana-Banking Problem, Patrick A. Tighe

Michigan Law Review

Numerous states have recently legalized recreational marijuana, which has created a burgeoning marijuana industry needing and demanding access to a variety of banking and financial services. Due, however, to the interplay between the federal criminalization of marijuana and federal anti-money laundering laws, U.S. financial institutions cannot handle legally the proceeds from marijuana activity. As a result, most financial institutions are unwilling to flout federal anti-money laundering laws, and so too few marijuana-related businesses can access banking services. This Note argues that the most viable policy option for resolving this “underbanking” problem is a financial cooperative approach such as a cannabis-only …

The Unintended Consequence To Legalizing Marijuana Use_ The Banking Conondrum, Florence Shu-Acquaye

Faculty Scholarship

No abstract provided.

The Neurobiology Of Cannabis Use Disorders: A Call For Evidence, Valentina Lorenzetti, Janna Cousijn, Nadia Solowij, Hugh Garavan, C Suo, Murat Yucel, Antonio Verdejo-Garcia

Faculty of Social Sciences - Papers (Archive)

Using cannabis is perceived by many as relatively harmless, but the adverse effects of problematic cannabis use are significant.

Mismatch Negativity And P50 Sensory Gating In Abstinent Former Cannabis Users, Samantha J. Broyd, Lisa-Marie Greenwood, Hendrika H. Van Hell, Rodney J. Croft, Hannah Coyle, Benjamin Lee-Bates, Juanita Todd, Stuart J. Johnstone, Patricia Michie, Nadia Solowij

Faculty of Social Sciences - Papers (Archive)

Prolonged heavy exposure to cannabis is associated with impaired cognition and brain functional and structural alterations. We recently reported attenuated mismatch negativity (MMN) and altered P50 sensory gating in chronic cannabis users. This study investigated the extent of brain functional recovery (indexed by MMN and P50) in chronic users after cessation of use. Eighteen ex-users (median 13.5 years prior regular use; median 3.5 years abstinence) and 18 nonusers completed (1) a multifeature oddball task with duration, frequency, and intensity deviants and (2) a P50 paired-click paradigm. Trend level smaller duration MMN amplitude and larger P50 ratios (indicative of poorer sensory …

The Role Of Cannabinoids In Neuroanatomic Alterations In Cannabis Users, Valentina Lorenzetti, Nadia Solowij, Murat Yuecel

Faculty of Social Sciences - Papers (Archive)

The past few decades have seen a marked change in the composition of commonly smoked cannabis. These changes primarily involve an increase of the psychoactive compound Delta(9)-tetrahydrocannabinol (THC) and a decrease of the potentially therapeutic compound cannabidiol (CBD). This altered composition of cannabis may be linked to persistent neuroanatomic alterations typically seen in regular cannabis users. In this review, we summarize recent findings from human structural neuroimaging investigations. We examine whether neuroanatomic alterations are 1) consistently observed in samples of regular cannabis users, particularly in cannabinoid receptor-high areas, which are vulnerable to the effects of high circulating levels of THC, …

The Risks Of Clouded Property Title For Cannabis Business Owners, Investors, And Creditors, Sean M. O'Connor, Jason Liu

Articles

This Article provides a brief primer on the surprising range of assets that the Controlled Substances Act forfeiture provisions govern for the state-legal cannabis businesses. It outlines these provisions for tangible as well as intangible property, with an emphasis on risks to state-legal cannabis businesses’ intellectual property and issued securities.

We argue that these forfeiture risks create clouded title for all subject tangible and intangible property—not only for the state-legal businesses and their proprietors, but also for those businesses’ outside investors, creditors, and suppliers/contractors.

Predicting Cannabis Cultivation On National Forests Using A Rational Choice Framework, Frank H. Koch, Jeffrey P. Prestemon, Geoffrey H. Donovan, Everett A. Hinkley, John M. Chase

USDA Forest Service / UNL Faculty Publications

Government agencies in the United States eradicated 10.3 million cannabis plants in 2010. Most (94%) of these plants were outdoor-grown, and 46% of those were discovered on federal lands, primarily on national forests in California, Oregon, and Washington. We developed models that reveal how drug markets, policies, and environmental conditions affect grow siting decisions. The models were built on a rational choice theoretical structure, and utilized data describing 2322 cannabis grow locations (2004–2012) and 9324 absence locations in the states' national forests. Predictor variables included cannabis market prices, law enforcement density, and socioeconomic, demographic, and environmental variables.We also used the …

Clinical Trials Of Medicinal Cannabis For Appetite-Related Symptoms From Advanced Cancer: A Survey Of Preferences, Attitudes And Beliefs Among Patients Willing To Consider Participation, Tim Luckett, Jane Phillips, Nicholas Lintzeris, David J. Allsop, J Lee, Nadia Solowij, Jennifer H. Martin, L Lam, R Aggarwal, Nikki Mccaffrey, David C. Currow, R Chye, Melanie Lovell, Iain Prof Iain Mcgregor, Meera Agar

Faculty of Social Sciences - Papers (Archive)

Australian clinical trials are planned to evaluate medicinal cannabis in a range of clinical contexts. Aims: To explore the preferences, attitudes and beliefs of patients eligible and willing to consider participation in a clinical trial of medicinal cannabis for poor appetite and appetite-related symptoms from advanced cancer.

Hippocampal Harms, Protection And Recovery Following Regular Cannabis Use, Murat Yucel, Valentina Lorenzetti, C Suo, Andrew Zalesky, Alex Fornito, Michael J. Takagi, Daniel Lubman, Nadia Solowij

Faculty of Social Sciences - Papers (Archive)

Shifting policies towards legalisation of cannabis for therapeutic and recreational use raise significant ethical issues for health-care providers seeking evidence-based recommendations. We investigated whether heavy cannabis use is associated with persistent harms to the hippocampus, if exposure to cannabidiol offers protection, and whether recovery occurs with abstinence. To do this, we assessed 111 participants: 74 long-term regular cannabis users (with an average of 15.4 years of use) and 37 non-user healthy controls. Cannabis users included subgroups of participants who were either exposed to Δ9-tetrahydrocannabinol (THC) but not to cannabidiol (CBD) or exposed to both, and former users with sustained abstinence. …

Cannabis Users' Experience Of Cannabis Craving : A Test Of The Cue-Reactivity Model, Mallory Jane Eglit Loflin

Legacy Theses & Dissertations (2009 - 2024)

Despite craving’s emphasis in treatment programs, little research has been conducted that specifically focuses on cannabis craving. Cannabis use, however, is the second most commonly cited reason for entering treatment for substance abuse and dependency. An understanding of how cannabis users experience craving is necessary. The current study compared heavy/daily cannabis users with infrequent users on measures of craving following presentation of cannabis cues. Hypotheses predicted changes in physiological (heart rate, galvanic skin response) and cognitive (simple reaction time, attentional bias) correlates of craving, and increased self-reported craving following cannabis cue exposure. Results found no significant increase in most indicators …

The Impact Of Experimentally Manipulated Post-Event Processing On The Relationship Between Social Anxiety And Cannabis Craving And Use, Anthony Harlan Ecker

LSU Doctoral Dissertations

Cannabis-related problems are major public health concerns. Social anxiety appears to be a unique risk factor that contributes to the development of cannabis-related problems, including cannabis use disorders. Given this risk, identification of cognitive vulnerabilities that may contribute to the onset and maintenance of co-occurring social anxiety and cannabis-related problems remains an important research goal. Socially anxious individuals experience anxiety and negative affect in response to cognitively reviewing past social situations (i.e., post-event processing [PEP]) and are likely to use cannabis to cope with negative affective states, which may occur during PEP. Thus, PEP may be one cognitive vulnerability factor …

Marijuana Compounds: A Nonconventional Approach To Parkinson’S Disease Therapy, Mariana Babayeva, Haregewein Assefa, Paramita Basu, Sanjeda Chumki, Zvi G. Loewy

Touro College of Pharmacy (New York) Publications and Research

Parkinson’s disease (PD), a neurodegenerative disorder, is the second most common neurological illness in United States. Neurologically, it is characterized by the selective degeneration of a unique population of cells, the nigrostriatal dopamine neurons. The current treatment is symptomatic and mainly involves replacement of dopamine deficiency.This therapy improves only motor symptoms of Parkinson’s disease and is associated with a number of adverse effects including dyskinesia. Therefore, there is unmet need for more comprehensive approach in the management of PD. Cannabis and related compounds have created significant research interest as a promising therapy in neurodegenerative and movement disorders. In this review …