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Antibacterial Coatings For Medical Devices Based On Glass Polyalkenoate Cement Chemistry, A. Coughlan, D. Boyd, C. W.I. Douglas, Mark R. Towler
Antibacterial Coatings For Medical Devices Based On Glass Polyalkenoate Cement Chemistry, A. Coughlan, D. Boyd, C. W.I. Douglas, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
A biofilm is an accumulation of micro-organisms and their extracellular products forming a structured community on a surface. Biofilm formation on medical devices has severe health consequences as bacteria growing in this lifestyle are tolerant to both host defense mechanisms and antibiotic therapies. However, silver and zinc ions inhibit the attachment and proliferation of immature biofilms. The objective of this study is to evaluate whether it is possible to produce silver and zinc-containing glass polyalkenoate cement (GPC) coatings for medical devices that have antibacterial activity and which may therefore inhibit biofilm formation on a material surface. Two silver and zinc-containing …
Encapsulation And Extended Release Of Anti-Cancer Anastrozole By Stealth Nanoparticles, Kumkum Sarkar, Hu Yang
Encapsulation And Extended Release Of Anti-Cancer Anastrozole By Stealth Nanoparticles, Kumkum Sarkar, Hu Yang
Chemical and Biochemical Engineering Faculty Research & Creative Works
To improve delivery efficiency of anastrozole, we applied dendrimer-based stealth nanoparticles to encapsulate anastrozole to formulate stealth anastrozole nanoparticles. This work demonstrated that stealth nanoparticles composed of a PAMAM dendrimers core and a PEG layer could encapsulate anastrozole, hence causing improved water solubility of anastrozole. Anastrozole encapsulation depended on concentration of stealth nanoparticles and generation of dendrimer. The extended release of anastrozole was achieved. We envisioned that this highly structurally adaptable stealth nanoparticle could be further biofunctionalized to construct a targeted therapeutic delivery system for breast cancer treatment.
The Processing, Mechanical Properties And Bioactivity Of Strontium Based Glass Polyalkenoate Cements, Anthony Wren, Daniel Boyd, Mark R. Towler
The Processing, Mechanical Properties And Bioactivity Of Strontium Based Glass Polyalkenoate Cements, Anthony Wren, Daniel Boyd, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
The suitability of zinc-based glass polyalkenoate cements (GPCs) for use in orthopaedics can be improved by the substitution of strontium into the glass phase which should impart improved radiopacity and bone forming properties to the cements without retarding strength. The purpose of this research was to produce novel GPCs based on calcium-strontium-zinc-silicate glasses and to evaluate their mechanical properties and biocompatibility with the ultimate objective of developing a new range of cements for skeletal applications. Three glass compositions, based on incremental substitutions of strontium for calcium, were synthesized; BT100 (0.16CaO, 0.36ZnO, 0.48SiO2), BT101 (0.04SrO, 0.12CaO, 0.36ZnO, 0.48SiO2 …
Comparison Of An Experimental Bone Cement With Surgical Simplex® P, Spineplex® And Cortoss®, D. Boyd, Mark R. Towler, A. Wren, O. M. Clarkin
Comparison Of An Experimental Bone Cement With Surgical Simplex® P, Spineplex® And Cortoss®, D. Boyd, Mark R. Towler, A. Wren, O. M. Clarkin
Chemical and Biochemical Engineering Faculty Research & Creative Works
Conventional polymethylmethacrylate (PMMA) cements and more recently Bisphenol-a-glycidyl dimethacrylate (BIS-GMA) composite cements are employed in procedures such as vertebroplasty. Unfortunately, such materials have inherent drawbacks including, a high curing exotherm, the incorporation of toxic components in their formulations, and critically, exhibit a modulus mismatch between cement and bone. The literature suggests that aluminum free, zinc-based glass polyalkenoate cements (Zn-GPC) may be suitable alternative materials for consideration in such applications as vertebroplasty. This paper examines one formulation of Zn-GPC and compares its strengths, modulus, and biocompatibility with three commercially available bone cements, Spineplex®, Simplex® P and Cortoss®. The setting times indicate …
The Role Of Sr²⁺ On The Structure And Reactivity Of Sro-Cao-Zno-Sio2 Ionomer Glasses, Daniel Boyd, Mark R. Towler, Sally Watts, Robert G. Hill, Anthony W. Wren, Owen M. Clarkin
The Role Of Sr²⁺ On The Structure And Reactivity Of Sro-Cao-Zno-Sio2 Ionomer Glasses, Daniel Boyd, Mark R. Towler, Sally Watts, Robert G. Hill, Anthony W. Wren, Owen M. Clarkin
Chemical and Biochemical Engineering Faculty Research & Creative Works
The suitability of Glass Polyalkenoate Cements (GPCs) for use in orthopaedics is retarded by the presence in the glass phase of aluminum, a neurotoxin. Unfortunately, the aluminum ion plays an integral role in the setting process of GPCs and its absence is likely to hinder cement formation. However, the authors have previously shown that aluminum free GPCs may be formulated based on calcium zinc silicate glasses and these novel materials exhibit significant potential as hard tissue biomaterials. To further improve their potential and given that Strontium (Sr) based drugs have had success in the treatment of osteoporosis, the authors have …
Tem Analysis Of Apatite Surface Layers Observed On Zinc Based Glass Polyalkenoate Cements, D. Boyd, Mark R. Towler, A. W. Wren, O. M. Clarkin, D. A. Tanner
Tem Analysis Of Apatite Surface Layers Observed On Zinc Based Glass Polyalkenoate Cements, D. Boyd, Mark R. Towler, A. W. Wren, O. M. Clarkin, D. A. Tanner
Chemical and Biochemical Engineering Faculty Research & Creative Works
The amorphous nature and composition of the surface apatite layers observed on glass polyalkenoate cements based on zinc silicate glasses (Zn-GPCs) after immersion in simulated body fluid (SBF) have been analyzed by the transmission electron microscopy (TEM). TEM was conducted using a JEOL JEM-2011 electron microscope operated at an accelerating voltage of 200 kV. The composition elements of the surface layer indicated the presence of calcium, phosphorous, zinc, and strontium within the amorphous structure. This composition, in particular the inclusion of Zn in the structure, indicates the lack of crystallinity associated with the formation of the apatite layers observed on …