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Inducible Caspase 9 Suicide Gene To Improve The Safety Of Allodepleted T Cells After Haploidentical Stem Cell Transplantation., Siok-Keen Tey, Gianpietro Dotti, Cliona M. Rooney, Helen E. Heslop, Malcolm K. Brenner Aug 2007

Inducible Caspase 9 Suicide Gene To Improve The Safety Of Allodepleted T Cells After Haploidentical Stem Cell Transplantation., Siok-Keen Tey, Gianpietro Dotti, Cliona M. Rooney, Helen E. Heslop, Malcolm K. Brenner

Faculty Publications

Addback of donor T cells following T cell-depleted stem cell transplantation (SCT) can accelerate immune reconstitution and be effective against relapsed malignancy. After haploidentical SCT, a high risk of graft-versus-host disease (GVHD) essentially precludes this option, unless the T cells are first depleted of alloreactive precursor cells. Even then, the risks of severe GVHD remain significant. To increase the safety of the approach and thereby permit administration of larger T cell doses, we used a suicide gene, inducible caspase 9 (iCasp9), to transduce allodepleted T cells, permitting their destruction should administration have adverse effects. We made a retroviral vector encoding …


Keeping Pace With Current Issues In Reporting Suicide And Mental Illness, J. Skehan, L. S. Burns, T. Hazell Jul 2007

Keeping Pace With Current Issues In Reporting Suicide And Mental Illness, J. Skehan, L. S. Burns, T. Hazell

Journal of University Teaching & Learning Practice

The Response Ability Project, funded under the Mindframe National Media Initiative in Australia, seeks to influence tertiary curricula so that graduates in journalism will be aware of and able to respond appropriately to issues relating to suicide and mental illness. Whilst the initial multi-media resources developed to support journalism educators have been received well, engagement with media organisations and individual journalists under other Mindframe projects have revealed further complexities associated with the reporting of suicide and mental illness. In particular, journalists have indicated that the issues become more problematic when they are required to report suicides in other contexts, such …


Inner Voice Dan Self-Esteem, Mellia Christia Jun 2007

Inner Voice Dan Self-Esteem, Mellia Christia

Makara Human Behavior Studies in Asia

This study had been done to comprehend inner voice phenomena in psychopathology, especially suicide ideation in normal people. Using quantitative method, inner voice and self-esteem instruments have been developed and given to 196 students Faculty of Psychology Universitas Indonesia. The results showed that there is significant correlation between inner voice and self esteem and no sex differences in inner voice and self esteem between participants. In general, subjects inner voice state is in underestimate self-esteem, despite most of the subjects have high self-esteem.


County Level Suicide Rates And Social Integration: Urbanicity And Its Role In The Relationship, Jacob Travis Walker May 2007

County Level Suicide Rates And Social Integration: Urbanicity And Its Role In The Relationship, Jacob Travis Walker

Theses and Dissertations

This study adds to the existing research concerning ecological relationships between suicide rates, social integration, and urbanicity in the U.S. Age-sex-race adjusted five-year averaged suicide rates for 1993-1997 and various measures of urbanicity are used. Some proposed relationships held true, while others indicate that social integration and urbanicity are so intertwined in their effects on suicide that no clear, unidirectional pattern emerges. The religious affiliation measure captured unique variations in the role religion plays in this relationship; depending on how urbanicity was measured. Findings suggest closer attention needs to be paid to how both urbanicity and religious affiliation are measured. …


Cleopatra’S Corpse: Motivation For Cleopatra’S Suicide In The Ancient Texts, Aubyn Eli Apr 2007

Cleopatra’S Corpse: Motivation For Cleopatra’S Suicide In The Ancient Texts, Aubyn Eli

Studies in Mediterranean Antiquity and Classics

No abstract provided.


The Transition From The Historical Inuit Suicide Pattern To The Present Inuit Suicide Pattern, Jack Hicks, Peter Bjerregaard, Matt Berman Jan 2007

The Transition From The Historical Inuit Suicide Pattern To The Present Inuit Suicide Pattern, Jack Hicks, Peter Bjerregaard, Matt Berman

Aboriginal Policy Research Consortium International (APRCi)

No abstract provided.


Lawyers Must Follow Their Inner Compasses, Bari Burke Jan 2007

Lawyers Must Follow Their Inner Compasses, Bari Burke

Faculty Journal Articles & Other Writings

This article reflects on the suicide of a Montana lawyer and offers some assumptions from Larry Krieger, a clinical law teacher and former litigator, on how lawyers can develop workable approaches to living and improving their professional lives.


Suicide By Firearm, Suicide Fatality, And Firearm Availability, Andrea Wallick Jan 2007

Suicide By Firearm, Suicide Fatality, And Firearm Availability, Andrea Wallick

UNLV Retrospective Theses & Dissertations

This study has three objectives. The first two objectives are to determine if neighborhood level gun availability has an effect on suicide method and suicide fatality. The third is to test that para-suicides (i.e., attempted suicides) with a mental disorder are more likely than para-suicides without a mental disorder to attempt suicide by firearm. Neighborhood is defined by zip code. The number of homicides for each zip code divided by the number of firearm related homicides in each zip code is used as a proxy for neighborhood level gun availability. Data on suicides and para-suicides occurring in Chicago front 1990-1997 …


G07-1715 High-Risk Behaviors Among Youth, Maria Rosario De Guzman, Kathy R. Bosch Jan 2007

G07-1715 High-Risk Behaviors Among Youth, Maria Rosario De Guzman, Kathy R. Bosch

University of Nebraska-Lincoln Extension: Historical Materials

This 2007 NebGuides discusses the status of high-risk behaviors among youth today, and offers suggestions for strategies to promote healthy behavioral choices for youth.


The Cultural Context Of Youth Suicide In Australia: Unemployment, Identity And Gender, Heidi E. Gilchrist, Glennys Howarth, Gerard Sullivan Jan 2007

The Cultural Context Of Youth Suicide In Australia: Unemployment, Identity And Gender, Heidi E. Gilchrist, Glennys Howarth, Gerard Sullivan

Faculty of Health and Behavioural Sciences - Papers (Archive)

This article considers the impact, in terms of life and death choices, of the economicexclusion of young people in Australia, where suicide is the leading cause of deathby injury. In the two decades from 1980 there was a dramatic increase in suiciderates for young males. Research demonstrates a correlation between youth suicideand unemployment but the complex relationship between the two has not been fullyinvestigated. This article explores the perceptions of young people, parents and serviceproviders of the cultural context of suicide and how it comes to be constructed as anoption for young people experiencing economic marginalisation.I n


A Story That Won't Fade Away: Compulsory Mass Suicide In The Battle Of Okinawa, Matthew Allen Jan 2007

A Story That Won't Fade Away: Compulsory Mass Suicide In The Battle Of Okinawa, Matthew Allen

Faculty of Law, Humanities and the Arts - Papers (Archive)

A Story That Won't Fade Away: Compulsory Mass Suicide in the Battle of Okinawa, Kawabata Shunichi and Kitazawa Yuki, Introduction by Matthew Allen


Integration-Regulation And Rural Suicide: A Test Of Three Alternative Models, Russell R. Davis Jan 2007

Integration-Regulation And Rural Suicide: A Test Of Three Alternative Models, Russell R. Davis

LSU Doctoral Dissertations

This dissertation is an examination of the social structural determinants of rural suicide rates. Examining rates of white male suicide in rural and urban counties of the U.S. Gulf States Region, this research adds to the existing literature by examining the theoretical and empirical implications of rural-urban location within sociology's Integration-Regulation Hypothesis of Suicide. Drawing upon suicide research from sociology, criminology and social psychology this study tests the differential explanatory power of three alternative theoretical and empirical predictor models of rural and urban suicide rates. Overall findings from this study underscore the need to examine suicide rates as distinct outcomes …


Reclaiming Martyrdom: Augustine's Reconstruction Of Martyrdom In Late Antique North Africa, Collin S. Garbarino Jan 2007

Reclaiming Martyrdom: Augustine's Reconstruction Of Martyrdom In Late Antique North Africa, Collin S. Garbarino

LSU Master's Theses

The cult of martyrs existed throughout the Mediterranean world in late antiquity, but local communities venerated the martyrs in their own ways and for their own reasons. During the fourth and fifth centuries, two factions of Christianity existed in North Africa. Catholicism and Donatism competed for the souls of North African Christians, and this competition influenced the development of the cult of martyrs in that region. The sermons on the martyrs by Augustine of Hippo (354-430) illuminate the milieu of North African Christianity's cult of martyrs and demonstrate that Augustine viewed "possessing" the martyrs as a key component in overcoming …