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Tribological Systems For The Evaluation Of Supercritical Carbon Dioxide Sterilized Ultra-High Molecular Weight Polyethylene, John Desjardins
Tribological Systems For The Evaluation Of Supercritical Carbon Dioxide Sterilized Ultra-High Molecular Weight Polyethylene, John Desjardins
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Polymeric biomaterials are especially susceptible to changes in mechanical and surface material properties as a result of sterilization processes that involve heat, moisture and/or irradiation. This is problematic for polymeric materials used in total joint replacement bearings, as these constructs must retain their superior mechanical and tribological properties over their expected 10-20 years of implantation. A younger more active patient population has now exacerbated this longevity issue with service lifetimes of 20+ years now being expected. Supercritical phase carbon dioxide (SC-CO2) is an industrial solvent that has shown great promise as a sterilizing agent in the food industry. Recently, SC-CO2 …
Stabilization Of Vascular Elastin By Treatment With Tannins, Jason Isenburg
Stabilization Of Vascular Elastin By Treatment With Tannins, Jason Isenburg
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Elastin is an important component of the extracellular matrix that endows cardiovascular tissue with the ability to extend and recoil repetitively. It has been shown that elastin may be vulnerable to enzymatic degradation and calcification in certain pathological cases. As a result, elastin degeneration may be associated with the failure of tissue-derived cardiovascular devices, such as bioprosthetic heart valves, as well as the development and progression of aortic aneurysms, a disease associated with progressive connective tissue degeneration of the arterial wall. Therefore, an elastin stabilizing agent may be beneficial for both applications. As such, our objectives for elastin stabilization are …