Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Institution
Articles 1 - 4 of 4
Full-Text Articles in Entire DC Network
Evaluation Of Kappa Opioid Receptor Specific Compounds And Their Effect On Ptsd-Like Behavioral Activity, Daniel Murnock
Evaluation Of Kappa Opioid Receptor Specific Compounds And Their Effect On Ptsd-Like Behavioral Activity, Daniel Murnock
Theses, Dissertations and Culminating Projects
Background: Post-traumatic stress disorder (PTSD) is a complex and multifaceted neurological disorder that is characterized by intrusive thoughts, avoidance behaviors, alterations in cognition and mood, and alterations in arousal and reactivity. Current studies utilize stress paradigms to mimic behavioral symptoms and neurobiological changes associated with PTSD. The project aims to instead utilize the kappa opioid system and three distinct Kappa Opioid Receptorspecific compounds (Salvinorin A, U50,488, and nor-BNI) to induce these changes. Pharmacokinetic analysis of Salvinorin A and U50,488 revealed a time of peak plasma concentration (Tmax) of 0.25 hours in both groups. 3-Chamber Social Novelty testing revealed a significant …
Assessment Of The Discriminative Stimulus Effects And Time Courses Of Salvinorin A And Two Synthetic Salvinorin B Derivatives, Methoxylmethyl (Mom) And Ethoxymethyl (Eom), Ethers In Rats Trained To Discriminate U69,593, Lisa M. Bell
Masters Theses
Research regarding the psychopharmacology of salvinorin A, the main psychoactive ingredient in the hallucinogenic plant Salvia divinorum, has been motivated largely by a recent increase in its recreational use and widespread media attention focused on this plant and its extracts. In addition, there is considerable evidence that drugs acting on kappa opioid receptors (KOR) may have therapeutic potential in the treatment of some neuropsychiatric conditions, including drug dependence and mood disorders. Although the neuropharmacological actions of salvinorin A are well established, only a few studies have explored the behavioral effects of this substance in comparison to the KOR agonist, …
The Kappa Opioid Agonist, Salvinorin A, Attenuates Locomotor Effects Of Morphine But Not Morphine-Induced Conditioned Place Preference, Stacy Dianne Engebretson
The Kappa Opioid Agonist, Salvinorin A, Attenuates Locomotor Effects Of Morphine But Not Morphine-Induced Conditioned Place Preference, Stacy Dianne Engebretson
Masters Theses
Salvinorin A (SA), a selective kappa opioid receptor agonist, is the main psychoactive ingredient in the plant Salvia divinorum. The addiction potential of this naturally occurring hallucinogen is currently under investigation using well-validated preclinical screening procedures, including conditioned place preference (CPP). The primary aim of the current study was to determine the effects of SA on CPP established by morphine in adult rats. A secondary aim was to determine if the vehicle used to dissolve SA, dimethylsulfoxide (DMSO), influenced the outcome of SA place conditioning. Rats were randomly assigned to one of four treatment groups: morphine (10 mg/kg) vs. …
Salvinorin A: Fragment Synthesis And Modeling Studies, Donna Mcgovern
Salvinorin A: Fragment Synthesis And Modeling Studies, Donna Mcgovern
Theses and Dissertations
Salvinorin A is a non-nitrogenous, selective kappa opioid receptor agonist with potent hallucinogenic properties. Because Salvinorin A has no basic nitrogen, it does not readily adhere to the “message-address” concept of selectivity for the opioid receptors. Therefore, a better understanding of how salvinorin A and its analogs interact with the kappa opioid receptor may shed some light on how salvinorin A obtains its potency and selectivity. The structure-affinity relationships (SAFIR) of salvinorin A and its analogs along with a discussion of the selectivity of the opioid receptors, is presented. A fragment of salvinorin A, methyl-3-acetoxy-4-oxocyclohexanecarboxylate, was synthesized to determine if …