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Molecular Mechanisms Underlying The Acquisition, Extinction And Reinstatement Of Cocaine-Associated Memory: Relevance To Addiction Processes, Shervin Albert Liddie

Open Access Dissertations

An important target for combating drug addiction is to understand the neurobiological mechanisms that sub-serve relapse to drug use. Drug addiction is thought to usurp the neural mechanisms of learning and memory. The conditioned place preference (CPP) paradigm which employs the principles of Pavlovian learning is often used to investigate the incentive value of drugs of abuse and the formation of drug-associated memory. One caveat to conditioned reward studies is the use of a fixed daily dose of the addictive drug during training. However, the transition from drug use to addiction in human addicts involves an escalation in drug intake. …