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Heritability Of Cognition Subscales In The Cache County Memory Study Cohort And Methods For Estimating Heritability, Colette Kelly Childs

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The rapid improvement of genotyping technology holds the promise of better understanding the genetic causes of complex disease. While traits of interest often include the presence or absence of disease, there is growing interest in intermediate phenotypes (or so-called endophenotypes) that may yield more information about disease onset or course. In particular, changes over time with respect to an investigative ordinal measure often contain significant predictive power, and rate-of-change phenotypes are becoming important in their own right when studying genetic association. Initial steps in assessing the potential genetic determinants of a continuous trait often involve estimating the degree of the …