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The Mechanisms Underlying Cocaine-Induced Overexpression Of Basic Fibroblast Growth Factor (Bfgf, Fgf2), An Effect Reversed By Extinction, Madalyn Hafenbreidel
The Mechanisms Underlying Cocaine-Induced Overexpression Of Basic Fibroblast Growth Factor (Bfgf, Fgf2), An Effect Reversed By Extinction, Madalyn Hafenbreidel
Theses and Dissertations
Drug addiction is characterized by compulsive drug use and chronic relapse despite negative consequences. Drug-induced structural and functional changes in the brain are thought to underlie these characteristics. One mechanism that may mediate these characteristics are growth factors, such as basic fibroblast growth factor (bFGF or FGF2), as they are necessary for cellular growth, survival, differentiation, and have roles in memory, mood, and anxiety disorders. bFGF mRNA and protein expression is increased following stimulant administration and is necessary for stimulant-induced changes in dendrites and behavioral sensitization. Moreover, addiction is maintained by cues associated with the drug, as they can can …
Sex Differences In Cognitive Decline In Mild Cognitive Impairment And Alzheimer's Disease, Juliann Thompson
Sex Differences In Cognitive Decline In Mild Cognitive Impairment And Alzheimer's Disease, Juliann Thompson
Theses and Dissertations
Alzheimer's disease (AD) is the most common form of dementia and results in progressive cognitive decline, particularly in regards to memory (National Institute on Aging, 2012). Prior research has shown sex differences in brain-atrophy rates of AD patients, with women experiencing a higher rate of progression in volume reduction (Skup et al., 2011). This suggests that there may also be differences in cognitive functioning between sexes, particularly in the rate of cognitive decline with a more rapid disease progression for dementing females compared to dementing males. The current study monitored memory function longitudinally in approximately 200 total participants, 100 with …
Eye Movement Effects In Simulated Object Recognition Memory Impairment, Dmitriy Kazakov
Eye Movement Effects In Simulated Object Recognition Memory Impairment, Dmitriy Kazakov
Theses and Dissertations
Malingering is the purposeful fabrication of symptoms for secondary gain. Memory problems are the most reported symptom, and object recognition tests are often used in clinical settings to evaluate these claims. Past research has shown that eye movements can indirectly index memory, in that greater viewing is directed at studied stimuli 500-750 ms after display onset. The present study evaluated eye movements as a potential method of detecting feigned memory impairment. Forty-eight participants, half simulators, studied standardized images and took a memory test. Several levels of analysis were used to detect broad trends and brief effects. Simulators performed significantly worse …
The Influence Of Test Anxiety On Memory, James J. Malloy
The Influence Of Test Anxiety On Memory, James J. Malloy
Theses and Dissertations
The purpose of this study was to investigate the relationship between test anxiety and memory among a college population (N = 42). Specifically, the goal was to ascertain whether text anxiety had a measurable effect on memory, which was represented by scores on the Nelson-Denny reading comprehension subtest. Participants were divided into a stressed group (N = 22) and a non-stressed group (N = 20) in order to compare scores from test-takers with anxiety to those who do not. It was hypothesized that (a) test anxiety would have a significant impact on test results, (b) the non-stressed group would score …