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Articles 1 - 17 of 17
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The Consolidation Of Memory Associations, Kyle A. Kainec
The Consolidation Of Memory Associations, Kyle A. Kainec
Doctoral Dissertations
Creating memories is a fundamental challenge for the human brain. To create memories, defining features of experiences must be stored distinguishably without forgetting other memories. Memory associations represent co-occurring features and defining features across experiences. Memory associations are represented as networks of information that are stored in the brain. New memory associations are encoded during experiences and can be used to update existing memory associations during offline intervals. However, the mechanisms that underlie how encoded memory associations are stored within existing networks during offline intervals remains unclear. The experiments in this dissertation address a significant theoretical gap in understanding the …
Characterizing The Roles Of The Variable Linker And Hub Domains In Camkii Activation, Noelle Dziedzic
Characterizing The Roles Of The Variable Linker And Hub Domains In Camkii Activation, Noelle Dziedzic
Doctoral Dissertations
Learning and memory formation at the cellular level involves decoding complex electrochemical signals between nerve cells, or neurons. Understanding these processes at the molecular level requires a comprehensive study of calcium-sensitive proteins that serve as signal mediators within cells. More specifically, the protein calcium/calmodulin-dependent protein kinase II (CaMKII) is a key regulator of downstream cellular signaling events in the brain, playing an important role in long term memory formation. CaMKII is encoded in humans on four different genes: alpha, beta, gamma and delta. For added complexity, each of these gene products can be alternatively spliced and translated into multiple protein …
There And Gone Again: Syntactic Structure In Memory, Caroline Andrews
There And Gone Again: Syntactic Structure In Memory, Caroline Andrews
Doctoral Dissertations
This dissertation addresses the relationship between hierarchical syntactic structure and memory in language processing of individual sentences. Hierarchical syntactic structure is a key part of human languages and language processing but its integration with memory has been uneasy ever since Sachs (1967) demonstrated that the syntactic structure of individual sentences is lost in explicit sentence recall tasks much faster than other linguistic information (lexical, semantic, etc.). Nonetheless, psycholinguists have continued to draw on memory in syntactic processing theories, in part due to (i) the explanatory power that memory can give to sentence processing hypotheses, and (ii) the conflicting results that …
A Genealogy Of Victimhood: Empathy And Memory In Recent German Fiction, Catherine E. Mcnally
A Genealogy Of Victimhood: Empathy And Memory In Recent German Fiction, Catherine E. Mcnally
Doctoral Dissertations
This dissertation addresses literary representations of empathy and altruism in Jenny Erpenbeck’s 2015 novel Gehen, Ging, Gegangen and Bodo Kirchhoff’s 2016 novel Widerfahrnis. These novels demonstrate continuities and discontinuities between German literature of the postwar, reunification and contemporary contexts.Analyzing expressions of empathy by Erpenbeck and Kirchhoff’s protagonists, I locate them in historical and literary contexts, the roots of which can be traced to the first generation of postwar German literature (1945-1968), particularly Heinrich Böll and Günter Grass. In both Grass and Böll’s early postwar fiction, German experiences of the war and its aftermath are foregrounded, and focus is placed …
Defining The Let-7 Microrna-Mediated Molecular Mechanisms Regulating T Cell Differentiation, Constance C. Angelou
Defining The Let-7 Microrna-Mediated Molecular Mechanisms Regulating T Cell Differentiation, Constance C. Angelou
Doctoral Dissertations
CD4+ and CD8+ T cells are lymphocytes of the adaptive immune system that play essential roles in immunity. Both T cell subsets recognize their cognate antigen through the T cell receptor (TCR), which induces the proliferation and differentiation of these antigen-specific cells into effector T cells. CD4+ T cells have the potential to differentiate into one of multiple lineages of helper T (Th) cells and participate indirectly in antigen clearance by orchestrating the function of other cells. CD8+ T cells differentiate into cytotoxic T lymphocytes (CTL), which directly contributes to the resolution of an infection by …
Testing The Convergent Retrieval Learning Theory Of Testing Effects, William J. Hopper
Testing The Convergent Retrieval Learning Theory Of Testing Effects, William J. Hopper
Doctoral Dissertations
What is learned from retrieving a memory that is not learned by studying the same information? In response to this question, I have proposed a new theory of retrieval-based learning in which I argue that retrieval strengthens the ability to completely activate all portions of a memory trace from an initial state of partial activation. In effect, retrieval serves to unitize the features of a memory, making the entire memory remain retrievable in the future when cue-related activation may be weaker. This theory, called the Primary and Convergent Retrieval (PCR) model, explains why practice tests produce both better long-term retention …
The Political Work Of Memory In Collaborative Caribbean Archaeology, Elena Sesma
The Political Work Of Memory In Collaborative Caribbean Archaeology, Elena Sesma
Doctoral Dissertations
This dissertation is the product of a community-based research project that sought to understand how descendants of the 19th century Millars Plantation on the southern end of Eleuthera, Bahamas continue to use and reinterpret the landscape that they have called home for over a century and a half. In 1871, the last owner of the Millars Plantation left the estate in her will to the descendants of her former slaves and servants. That descendant community still upholds their right to this land today, although in recent years, a Bahamian developer has attempted to gain title to the acreage through the …
Hashtag Holocaust: Negotiating Memory In The Age Of Social Media, Erica Fagen
Hashtag Holocaust: Negotiating Memory In The Age Of Social Media, Erica Fagen
Doctoral Dissertations
This study examines the representation of Holocaust memory through photographs on the social media platforms of Flickr and Instagram. It looks at how visitors – armed with digital cameras and smartphones – depicted their experiences at the former concentration camps of Auschwitz-Birkenau, Dachau, Sachsenhausen, and Neuengamme. The study’s arguments are twofold: firstly, social media posts about visits to former concentration camps are a form of Holocaust memory, and secondly, social media allows people from all backgrounds the opportunity to share their memories online. Holocaust memory on social media introduces a new, digital kind of memory called “filtered memory.” This study …
Recollections: Memory, Materiality, And Meritocracy At The Dr. James Still Historic Office And Homestead, Marc Lorenc
Recollections: Memory, Materiality, And Meritocracy At The Dr. James Still Historic Office And Homestead, Marc Lorenc
Doctoral Dissertations
The dissertation explores how memory, materiality, and meritocracy articulate together to create a meritocratic subjectivity at the Dr. James Still Historic Office and Homestead. This subjectivity frames how we experience and promote the history of Dr. James Still through an authorized heritage discourse (AHD) (Smith 2006) that promotes and re-ingrains American meritocracy, specifically the “bootstrap myth”, as a “common sense”. Using a combination of archaeological excavations, documentary analysis, and ethnography conducted under the Dr. James Still Community Archaeology Project (DJSCAP), I explore how cultural artifacts shape and influence our subjectivities at the site and more broadly in everyday interactions with …
Let-7 Mirnas Program The Fate Of Cd8 T Cells, Alexandria Wells
Let-7 Mirnas Program The Fate Of Cd8 T Cells, Alexandria Wells
Doctoral Dissertations
CD8 T cells are the cytotoxic effectors of the adaptive immune response, clearing virally infected and cancerous cells within the host. CD8 T cells acquire their cytotoxic function by differentiating into cytotoxic T lymphocytes (CTLs). Once the CTLs have cleared the antigen, the majority of responding cells will die during contraction; however, a small population of the antigen-specific responders will remain, differentiating into long-lived memory cells that provide potent protection to the host upon re-encounter with the antigen. These differentiation programs often become disturbed in cases of chronic infection and cancer. Instead, CD8 T cells are subverted into the so-called …
Assessing The Long-Term Sequelae Of Mild Traumatic Brain Injury, Janna Mantua
Assessing The Long-Term Sequelae Of Mild Traumatic Brain Injury, Janna Mantua
Doctoral Dissertations
A mild traumatic brain injury (mTBI), also known as a concussion, is defined as an injury that results in an alteration of consciousness or mental status. Previous studies have shown mTBI populations experience a number of chronic (> 1 year) symptoms, such as sleep disturbances (e.g., sleep stage alterations), mood alterations (e.g., depressive symptoms), and cognitive alterations (e.g., poor concentration). The three chapters of this dissertation sought to explore these long-term sequelae and the possible interrelations between them. In the first experiment, sleep-dependent memory consolidation of neutral stimuli was probed in a chronic mTBI sample and a control, uninjured sample. …
Fantasy Frontier: Old West Theme Parks And Memory In California, Amanda Tewes
Fantasy Frontier: Old West Theme Parks And Memory In California, Amanda Tewes
Doctoral Dissertations
This study examines sites of Old West tourism—specifically the three California theme parks of Knott’s Berry Farm, Calico Ghost Town, and Frontier Village—as avenues through which the myth of “the West” gets propagated, even among the people of the American West, and even if these sites do not reflect the actual history of the region. California’s Old West theme parks act as windows into mid-twentieth-century cultural conflicts of politics and identity within the state. But these sites are artifacts of a particular historical moment and their fantasy of the Old West memorializes mid-century renderings of the past rather than nineteenth-century …
Lost-And-Found Photos: Practices And Perceptions, Todd J. Wemmer
Lost-And-Found Photos: Practices And Perceptions, Todd J. Wemmer
Doctoral Dissertations
Personal photographs become separated from their original owners in a number of ways, due to time or tragedy, sometimes ending up in strangers’ hands. Dealers, collectors, curators, bloggers, scholars, and families actively seek what are frequently called “orphaned,” “abandoned,” or “found” photos and present them to the public in multiple formats. This dissertation offers an analysis of the practices and perceptions that surround these presentations, and it argues for use of a more inclusive term (“lost-and-found”) to describe personal photos that are connected to both finders and losers. Data were collected in three primary ways: (1) examination of the current …
Change Of Sight, Sites Of Creativity: The Visual Arts In Albania After Socialism, Sofia Kalo
Change Of Sight, Sites Of Creativity: The Visual Arts In Albania After Socialism, Sofia Kalo
Doctoral Dissertations
This dissertation examines Albania’s fine art world after the end of state socialism in 1991. Drawing on two years of anthropological fieldwork (January –August 2006 and January 2010-August 2011) in Tirana, Albania’s capital city, this study investigates how the withdrawal of state support and oversight on the arts, the introduction of a market economy and efforts toward European belonging have been reflected, responded to and challenged in the discourses and practices of aesthetic production. Viewing art as a productive site of social meaning, where people perform and struggle over their identities, their pasts and futures, this dissertation explores the social …
The Role Of Napping On Memory Consolidation In Preschool Children, Laura Kurdziel
The Role Of Napping On Memory Consolidation In Preschool Children, Laura Kurdziel
Doctoral Dissertations
Nocturnal sleep has been shown to benefit memory in adults and children. During the preschool age range (~3-5 years), the distribution of sleep across the 24-hour period changes dramatically. Children transition from biphasic sleep patterns (a nap in addition to overnight sleep) to a monophasic sleep pattern (only overnight sleep). In addition, early childhood is a time of neuronal plasticity and pronounced acquisition of new information. This dissertation sought to examine the relationship between daytime napping and memory consolidation in preschool-aged children during this transitional time. Children were taught either a declarative or an emotional task in the morning, and …
Effects Of Aging On Sleep-Dependent Consolidation Of Declarative Memory, Bengi Baran
Effects Of Aging On Sleep-Dependent Consolidation Of Declarative Memory, Bengi Baran
Doctoral Dissertations
Sleep plays a critical role in memory consolidation. However, aging is associated with changes in sleep architecture and memory impairments. The goal of the present study was to identify age-related changes in the memory function of sleep by investigating sleep-dependent changes in neural activation patterns during memory retrieval in young and older adults. Healthy young (21-29 years) and older (62-74 years) adults were trained on a declarative word-pair learning task. Recall was tested 5 hr later while undergoing functional magnetic resonance imaging (fMRI). Participants completed this testing procedure twice, separated by 1 week; once following a mid-day nap and once …
The Genealogy Of Dislocated Memory: Yugoslav Cinema After The Break, Dijana Jelaca
The Genealogy Of Dislocated Memory: Yugoslav Cinema After The Break, Dijana Jelaca
Doctoral Dissertations
This dissertation analyzes the post-conflict cinema in the region of the former Yugoslavia, and the way that this particular form of cultural production establishes affective regimes within which bearing witness to trauma becomes variously articulated to national identity, history, politics, and memory. Using affect and trauma theories as organizing frameworks, my project looks at the way in which post-Yugoslav cinema has become a pivotal outlet for the process of working through the trauma of recent violent history in the region. I examine this process through its various iterations, from its applications to identity - be it ethnic, national, class, age, …