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Local Feature Selection For Multiple Instance Learning With Applications., Aliasghar Shahrjooihaghighi
Local Feature Selection For Multiple Instance Learning With Applications., Aliasghar Shahrjooihaghighi
Electronic Theses and Dissertations
Feature selection is a data processing approach that has been successfully and effectively used in developing machine learning algorithms for various applications. It has been proven to effectively reduce the dimensionality of the data and increase the accuracy and interpretability of machine learning algorithms. Conventional feature selection algorithms assume that there is an optimal global subset of features for the whole sample space. Thus, only one global subset of relevant features is learned. An alternative approach is based on the concept of Local Feature Selection (LFS), where each training sample can have its own subset of relevant features. Multiple Instance …
Social Disorganization And Violent Crime Across Nonmetropolitan Areas Of Kentucky., Daniel Ray Jude
Social Disorganization And Violent Crime Across Nonmetropolitan Areas Of Kentucky., Daniel Ray Jude
Electronic Theses and Dissertations
This macro-level study examines the effects of social disorganization predictors on violent crime registered in nonmetropolitan areas of Kentucky from 2012 to 2016. The study intends to expand the line of research interested in verifying the applicability of the social disorganization theory (Shaw & McKay, 1942), including its new theoretical developments, to non-urban settings and plans to contribute to the literature willing to provide a better understanding of violent crime in rural areas. In response to Narag et al.’s (2009) call for a theoretical integration of environmental contaminants among the ecological factors that influence variations in crime, the study also …
The Impact Of Statin Use On Outcomes Of Diabetic Adult Patients Hospitalized For Community Acquired Pneumonia., Joel Lanceta
The Impact Of Statin Use On Outcomes Of Diabetic Adult Patients Hospitalized For Community Acquired Pneumonia., Joel Lanceta
Electronic Theses and Dissertations
BACKGROUND: Statins, a class of drugs that treat hyperlipidemia, may have an immunosuppressive effect for patients with community acquired pneumonia (CAP). Retrospective and in vitro studies have suggested an immunomodulatory, antioxidative and anticoagulant effects from statin use in patients with Type 2 Diabetes Mellitus (T2DM) hospitalized for CAP. Prospective studies that have tested any effect of statin therapy on patients with T2DM and CAP have not been found literature. To date, prospective studies showing of the effects statin therapy may have on T2DM patients hospitalized for CAP are not available. METHODS: This dissertation is a secondary analysis using deidentified data …
Role Of Meibum And Tear Phospholipids In The Evaporative Water Loss Associated With Dry Eye., Samiyyah M. Sledge
Role Of Meibum And Tear Phospholipids In The Evaporative Water Loss Associated With Dry Eye., Samiyyah M. Sledge
Electronic Theses and Dissertations
It is generally believed that the tear film lipid surface film inhibits the rate of evaporation (Revap) of the underlying tear aqueous. It is also generally believed that changes in the composition of the tear film lipid layer is responsible for an increase in Revap in patients with dry eye. Both of these ideas have never been proven. The purpose of the current studies was to test these ideas. Revap was measured in vitro gravimetrically. Lipid spreading was measured using Raman spectroscopy and microscopy. The influence of the following surface films on the Revap of the sub phase of physiologically …
Theoretical Investigation Of The Co-C Bond Activation In Methylcobalamin And Adenosylcobalamin-Dependent Systems: Mechanistic Insights., Arghya Pratim Ghosh
Theoretical Investigation Of The Co-C Bond Activation In Methylcobalamin And Adenosylcobalamin-Dependent Systems: Mechanistic Insights., Arghya Pratim Ghosh
Electronic Theses and Dissertations
The vitamin B12 derivates, otherwise known as cobalamin (Cbl), are ubiquitous organometallic cofactors. The biologically active forms of Cbl, such as methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), act as cofactors in different physiological reactions for both prokaryotes and eukaryotes. A crucial aspect of the Cbl-mediated systems is the activation of the organometallic Co-C bond that plays a critical role in its catalytic activity. One of the most remarkable features of this Co-C bond is its unusual activation in AdoCbl-dependent enzymatic reactions, where a trillion-fold rate acceleration of the Co-C bond cleavage is observed inside the enzyme compared to the isolated …
Black Codes Re-Envisioned: The Dred Scott Majority Opinion As An Antiblack Performative Speech Act., Tiffany Dillard-Knox
Black Codes Re-Envisioned: The Dred Scott Majority Opinion As An Antiblack Performative Speech Act., Tiffany Dillard-Knox
Electronic Theses and Dissertations
This dissertation is a discursive analysis of the decision in the Dred Scott v Sandford, 1857 case written by Chief Justice Roger Taney. It begins with an overview of the literature on performative speech acts, focusing on the aspects of performatives that relate to Louis Miron and Jonathan Xavier Inda’s thesis that race is a performative speech act. Breaking from their use of race as the analytic, this analysis is situated within a black/nonblack paradigm. This provides a framework that focuses on the unique ways in which the discourse of the text enacts, accumulates and renders blackness fungible. The …
Digital Design And Thermomechanical Process Simulation For 3d Printing With Abs And Soyhull Fibers Reinforced Abs Composites., Saleh Khanjar
Digital Design And Thermomechanical Process Simulation For 3d Printing With Abs And Soyhull Fibers Reinforced Abs Composites., Saleh Khanjar
Electronic Theses and Dissertations
Recent demonstrations with fused filament fabrication (FFF) 3D printing have shown to produce prototypes as well as production components. Additionally, due to the FFF process platforms being low-cost and readily available there has been a high-demand to produce on-demand parts for various applications in automotive, in-space manufacturing and electronic industries. However, current limitations such as limited availability of advanced composites materials, and guidelines for design-for-manufacturing make the process prone to trial-and-error experiments both at the materials development, product design and manufacturing stage. In this work, new thermomechanical process simulations platform, Digimat-AM has been evaluated to address and demonstrate digital design …
Clube Da Esquina 1970-1972: A Compositional Analysis According To Ron Miller's Modal Jazz Concepts., Tullio Mesquita Cunha
Clube Da Esquina 1970-1972: A Compositional Analysis According To Ron Miller's Modal Jazz Concepts., Tullio Mesquita Cunha
Electronic Theses and Dissertations
The main goal of this paper is to analyze the harmonic and melodic transcriptions from the LPs Milton and Clube da Esquina according with the book Modal Jazz Composition and Harmony by Ron Miller in order to exemplify the compositional idiosyncrasy from Milton Nascimento, and especially, Lô Borges. The result is that Borges has a linear approach to write melodies while his vertical line has the use of open strings chords with mixed upper structures such as tertian, quartal and clusters.
Modeling Driver Distraction Mechanism And Its Safety Impact In Automated Vehicle Environment., Song Wang
Modeling Driver Distraction Mechanism And Its Safety Impact In Automated Vehicle Environment., Song Wang
Electronic Theses and Dissertations
Automated Vehicle (AV) technology expects to enhance driving safety by eliminating human errors. However, driver distraction still exists under automated driving. The Society of Automotive Engineers (SAE) has defined six levels of driving automation from Level 0~5. Until achieving Level 5, human drivers are still needed. Therefore, the Human-Vehicle Interaction (HVI) necessarily diverts a driver’s attention away from driving. Existing research mainly focused on quantifying distraction in human-operated vehicles rather than in the AV environment. It causes a lack of knowledge on how AV distraction can be detected, quantified, and understood. Moreover, existing research in exploring AV distraction has mainly …
Atomistic Investigation Of Phase Stability And Sodium Ion Conduction In Sulfide Electrolytes., Sabina Zakhidovna Chertmanova
Atomistic Investigation Of Phase Stability And Sodium Ion Conduction In Sulfide Electrolytes., Sabina Zakhidovna Chertmanova
Electronic Theses and Dissertations
In this thesis, we employ a combination of density functional theory (DFT) calculations, and ab initio molecular dynamics (AIMD) simulations to identify the effect of chemical doping on (a) thermodynamic phase stability, and (b) Na-ion conduction in Na3SbS4 (NSS) solid-state electrolytes. We found that (a) Se doped electrolytes, namely, Na3SbSexS4-x undergo a tetragonal-to-cubic structural phase transition at x > 3 (Se-rich), and (b) the size, valence, and electronegativity of chemical dopants that substitute Na in Na3SbS4 have a cumulative profound impact on Na-ion conductivity. Specifically, substituting Na with higher valence …
Computational Investigations Of The Photochemical Properties Of B12-Dependent Systems: From Solution To Enzymes., Megan Toda Mackintosh
Computational Investigations Of The Photochemical Properties Of B12-Dependent Systems: From Solution To Enzymes., Megan Toda Mackintosh
Electronic Theses and Dissertations
The photochemical properties of the B12 family of molecules (cobalamins = Cbls) have been known for many years yet only until the 21st century have applications for the light-sensitivity of Cbls come to the surface. Photolabile Cbls can be used for the delivery of therapeutics with spatial and temporal control, in the generation of hydroxyl radicals, and in nature, as demonstrated in the catalytic cycle of coenzyme B12-dependent photoreceptors. This dissertation describes the use of computational methods to explore the photochemical properties of Cbl systems including antivitamins B12, a thiolato-cobalamin, and the coenzyme B …
Exploring The Contextual Factors And Decision-Making Process Of Risky Sexual Behavior Among Homeless Adults In Louisville, Kentucky., Sarah C. Van Heiden
Exploring The Contextual Factors And Decision-Making Process Of Risky Sexual Behavior Among Homeless Adults In Louisville, Kentucky., Sarah C. Van Heiden
Electronic Theses and Dissertations
Homelessness is a complex public health issue; individuals who experience homelessness are said to engage in risky sexual behaviors at an increased rate and experience a higher prevalence of sexually transmitted infection (STI). While the sexual behaviors of homeless adolescents are commonly studied, little is known about the sexual behaviors of the growing population of older adults, or how they make decisions to engage in sex. Three aims guided this research: 1) to describe the sexual behaviors and sexual decision-making process of homeless older adults, 2) to examine how homeless older adults evaluate the outcomes associated with engaging in risky …
The Economic Rationality Of Consumption In The Mycenaean Political Economy And Its Role In The Reproduction Of Social Personae: Modeling Prestige Networks., Devin Alexander Stephens
The Economic Rationality Of Consumption In The Mycenaean Political Economy And Its Role In The Reproduction Of Social Personae: Modeling Prestige Networks., Devin Alexander Stephens
Electronic Theses and Dissertations
This thesis is a theoretical examination of the economic rationality of consumption as it existed within the Mycenaean political economy. Using a modified paradigm of social network analysis, a semiotic approach is used in the study of identity expression and economic stratification present at three Late Helladic cemeteries. In doing so, the claim that exchange strategies which existed outside of palatial redistribution were present in the Late Helladic was substantiated as a similar logic of mortuary stratification which existed during the palatial era was also found to have existed after the shift to the post-palatial era and the collapse of …
Social Cognition, Impulsivity, And Emotion Regulation Factors In Aggressive Behavior Among Children With Attention-Deficit/Hyperactivity Disorder., Kelly E. Slaughter
Social Cognition, Impulsivity, And Emotion Regulation Factors In Aggressive Behavior Among Children With Attention-Deficit/Hyperactivity Disorder., Kelly E. Slaughter
Electronic Theses and Dissertations
Children with Attention-Deficit/Hyperactivity Disorder (ADHD) exhibit greater levels of aggressive behavior than their typically developing peers, often resulting in impairment in social and family functioning. Aggressive behavior is often differentiated into two functions: reactive, or “hot-blooded” and proactive, or “cold-blooded” aggression. Prior research has identified several factors contributing to aggressive behavior within a general population, including emotion dysregulation, negative urgency, social information processing (SIP), and parenting behaviors. A paucity of research has examined these factors within an ADHD population. Thus, the present study aimed to examine social, emotional, behavioral, and cognitive factors associated with aggression among children with ADHD. Specifically, …
Hospital-Based Professional Spiritual Care: Evaluating The Utilization, Availability, And Impact Of Chaplains., Kelsey B. White
Hospital-Based Professional Spiritual Care: Evaluating The Utilization, Availability, And Impact Of Chaplains., Kelsey B. White
Electronic Theses and Dissertations
BACKGROUND: The Affordable Care Act, enacted in 2010, transformed healthcare policy and forced hospitals to reevaluate traditional methods for care delivery. Researcher advocated for patient-centered models of care to reduce costs, address inequitable access to services, and improve service quality. These models prioritize patient values, preferences, and beliefs inclusive of patients’ religious and spiritual needs. Professional chaplains provide religious and spiritual care within many hospital settings. This dissertation explored the characteristics of hospitalized persons using chaplains, the factors associated with a hospital reporting a chaplaincy department, and how those services impacted patient satisfaction. METHODS: The first analysis used a two-part …
An Exploration Of Afrocentric Features At A Black Homeschool Collective., Tytianna Nikia Maria Wells
An Exploration Of Afrocentric Features At A Black Homeschool Collective., Tytianna Nikia Maria Wells
Electronic Theses and Dissertations
This dissertation explores the development and benefits of familial relationships as the primary feature of Afrocentricity at Black Scholars Academy (BSA), a Pre-Kindergarten (Pre-K) through 12th-grade Black homeschool collective in the United States. This qualitative study draws upon Afrocentricity as a theoretical framework to analyze and interpret data collected from classroom observations, individual interviews with current and former teachers and students, and textual artifacts between July and November 2019. Familial relationships—an African time orientation, a personalized learning plan, OurStory, and Rising Meeting—are present in BSA. Familial relationships helped students develop cultural pride, agency, self-determination, independence, liberation through education, and a …
Assessing Universal Basic Income Proposals: A Comprehensive Analysis Of Established Studies., Zachary Paul Baker
Assessing Universal Basic Income Proposals: A Comprehensive Analysis Of Established Studies., Zachary Paul Baker
College of Arts & Sciences Senior Honors Theses
The development of welfare within western cultures has become incredibly polarized over the last decades. Propositions for ideas such as Universal Basic Income (UBI) has reemerged into the mainstream conversation, with some lofty promises. What is the credibility of UBI as a welfare policy platform? Do the results of the studies on the effects of cash-transfers show the possibility of UBI as a new national program, or do they reveal issues that highlight major structural problems with UBI? This thesis examines over twenty different studies within various categories of cash-transfers to see the positives and negatives revealed by previous researchers. …
Preclinical Development Of Epicertin, A Novel Biotherapeutic For The Treatment Of Ulcerative Colitis., Micaela Ann Reeves
Preclinical Development Of Epicertin, A Novel Biotherapeutic For The Treatment Of Ulcerative Colitis., Micaela Ann Reeves
Electronic Theses and Dissertations
Epicertin (EPT) is a recombinant variant of the cholera toxin B subunit with a C-terminal KDEL endoplasmic retention motif. Previously, orally administered EPT demonstrated mucosal healing activity in acute and chronic dextran sulfate sodium colitis models, indicating its therapeutic potential for ulcerative colitis (UC) treatment. However, oral dosing with EPT requires neutralization of gastric acid prior to administration, hindering its facile application in the treatment of chronic diseases like UC. One solution to this issue is that EPT may also be administered intracolonically without losing efficacy. This work describes the determination of a target intracolonic dose of EPT for future …
Investigation Of Mitochondrial Inheritance In The Smut Fungus Sporisorium Reilianum., Hector Eduardo Mendoza
Investigation Of Mitochondrial Inheritance In The Smut Fungus Sporisorium Reilianum., Hector Eduardo Mendoza
Electronic Theses and Dissertations
An important goal in evolutionary biology is to address the origin of Earth’s immense biodiversity through the evolution of complex sexual reproduction mechanisms in eukaryotes. Inheritance of mitochondria during sexual reproduction has received special attention in recent years, as these organelles cannot be synthesized de novo and must be transmitted from parent to offspring. The importance of these organelles far exceeds its common function as the energy-producing “powerhouse” of the cell, as it has been found to also be involved in fundamental processes like apoptosis, aging and metabolic homeostasis. Thus, appropriate inheritance of mitochondria is essential for growth and development …
The Influence Of Dual Enrollment On Rural Student College Persistence., Jeanne Toure Guerrero
The Influence Of Dual Enrollment On Rural Student College Persistence., Jeanne Toure Guerrero
Electronic Theses and Dissertations
Using the High School Longitudinal Study of 2009 (HSLS:09), this study addresses the research question of whether dual enrollment (DE) influences first- to third-year college persistence at a four-year institution, controlling for gender, race/ethnicity, socioeconomic status (SES), and rurality. The results revealed that there are statistically significant differences between the independent variables of DE Participation, Gender, Race/Ethnicity, SES, and Rurality and the dependent variable of College Persistence. Controlling for other variables, the following main effects results emerged: Students participating in DE courses were more likely to persist than non-DE students. Female DE students were more likely to persist when compared …
Q-Griffithsin Interactions And Utility For The Prevention And Treatment Of Mucosal Infections., Henry Nabeta
Q-Griffithsin Interactions And Utility For The Prevention And Treatment Of Mucosal Infections., Henry Nabeta
Electronic Theses and Dissertations
Griffithsin (GRFT) is a carbohydrate binding agent (lectin) that was originally identified in the red alga Griffithsia sp. Q-Griffithsin (Q-GRFT) is an oxidation stable analog of GRFT. GRFT has demonstrated inhibitory activity against HIV-1, Coronaviruses, Hepatitis C, influenza and Ebola viruses. The broad-spectrum activity suggests the potential utility of this lectin in a wide range of viral infections. However, the lectin’s activity in mucosal infections has not been extensively studied. Using in vitro, ex vivo and in vivo assays, we have demonstrated that Q-GRFT maintains the ability to bind glycosylated ligands following incubation in murine, macaque and human rectal …
Visualizing Anhydrobiosis: Liquid-Liquid Phase Separation, Membraneless Organelles, And Cellular Reorganization., Clinton J. Belott
Visualizing Anhydrobiosis: Liquid-Liquid Phase Separation, Membraneless Organelles, And Cellular Reorganization., Clinton J. Belott
Electronic Theses and Dissertations
Water is an integral and necessary component of life. It is then, exceedingly remarkable that some species are capable of surviving virtually complete water loss for extended periods of time. Several decades of intense research into anhydrobiosis, or life without water, have given significant insights into the molecular mechanisms governing this phenomenon. Anhydrobiosis-related intrinsically disordered (ARID) proteins have been demonstrated to be critically important for desiccation tolerance in many anhydrobiotic species and exhibit a considerably wide range of protective properties that include membrane stabilization, reinforcing bioglass formation, and protein stabilization. This dissertation begins with cellular dielectrophoresis suggesting that two ARID …
Hybrid Structural Health Monitoring Using Data-Driven Modal Analysis And Model-Based Bayesian Inference., Jice Zeng
Electronic Theses and Dissertations
Civil infrastructures that are valuable assets for the public and owners must be adequately and periodically maintained to guarantee safety, continuous service, and avoid economic losses. Vibration-based structural health monitoring (VBSHM) has been a significant tool to assess the structural performance of civil infrastructures over the last decades. Challenges in VBSHM exist in two aspects: operational modal analysis (OMA) and Finite element model updating (FEMU). The former aims to extract natural frequency, damping ratio, and mode shapes using vibrational data under normal operation; the latter focuses on minimizing the discrepancies between measurements and model prediction. The main impediments to real-world …
Pyridine Nucleotide Redox Potential In Coronary Smooth Muscle Couples Myocardial Blood Flow To Cardiac Metabolism., Marc Matthew Dwenger
Pyridine Nucleotide Redox Potential In Coronary Smooth Muscle Couples Myocardial Blood Flow To Cardiac Metabolism., Marc Matthew Dwenger
Electronic Theses and Dissertations
The maintenance of myocardial oxygen supply during stress is essential for sustaining cardiac health. Enhancement of coronary blood flow upon increases in myocardial oxygen demand (i.e., hyperemia) relies on regulation of voltage-gated K+ (Kv) channels by their intracellular β subunits (i.e., Kvβ proteins). Considering that, Kvβ proteins are aldo-keto reductases (AKRs) and regulate Kv channel gating, we tested the hypothesis that elevation of myocardial oxygen demand modifies intracellular NAD(H) in arterial myocytes. Furthermore, we tested whether the resultant change in the redox state of the pyridine nucleotide pool directly regulates coronary Kv1 channel activity. High-resolution imaging mass spectrometry and …
Impact Of Pank1 Deletion On Mitochondrial Acetylation And Cardiac Function During Pressure Overload., Timothy N. Audam
Impact Of Pank1 Deletion On Mitochondrial Acetylation And Cardiac Function During Pressure Overload., Timothy N. Audam
Electronic Theses and Dissertations
Recent studies have associated elevated protein acetylation levels with heart failure in humans. Although mechanisms promoting elevated acetylation levels are not fully known, excess acetyl-CoA may drive enzyme-independent acetylation of cardiac proteins. Accumulation of acetyl-CoA depends on the availability of sufficient CoA, whose production is regulated by pantothenate kinases in the CoA biosynthetic pathway. We show that cardiac proteins are hyperacetylated during heart failure in humans and tested in mice whether limiting CoA abundance would improve ventricular remodeling during pressure overload-induced hypertrophy. We limited cardiac CoA levels by deleting the rate-limiting enzyme in CoA biosynthesis, Pank1 (one of three PANK-encoding …
Investigations Of Potential Mechanisms Underlying Spinal Cord Injury-Induced Polyuria., Jason H. Gumbel
Investigations Of Potential Mechanisms Underlying Spinal Cord Injury-Induced Polyuria., Jason H. Gumbel
Electronic Theses and Dissertations
Spinal cord injury (SCI) results in neurological impairments including motor, sensory, and autonomic dysfunction. These neurological deficits result in a litany of complications apart from muscular paralysis, including bladder, bowel, cardiovascular, and sexual function. SCI-induced polyuria (the overproduction/passage of urine) remains understudied, and therefore mechanisms behind it are largely unknown and require extensive investigation for potential targeted therapies to improve quality of life. The objective of this dissertation was to investigate potential mechanisms of SCI-induced polyuria and explore potential therapies to improve quality of life in the SCI population. Metabolic cages, Western blot, enzyme-linked immunoassay, and immunostaining were first used …
Synthesis, Crystal Structure And Ionic Conductivity Of Ruddlesden-Popper Oxide Materials: Effects Of Ionic Radii And Defects On Lithium-Ionic Conductivity., Selorm Joy Fanah
Synthesis, Crystal Structure And Ionic Conductivity Of Ruddlesden-Popper Oxide Materials: Effects Of Ionic Radii And Defects On Lithium-Ionic Conductivity., Selorm Joy Fanah
Electronic Theses and Dissertations
Layered perovskite oxides of the Ruddlesden-Popper (RP) type structure can be good lithium-ion conductors for solid electrolyte applications in all-solid-state batteries, due to the large gap separating octahedral layers which can be useful pathways for Li-ion conduction. However, little work has been done on their lithium-ion transport properties in these materials despite their interesting structural properties. This work highlights the synthesis and study of the ionic conductivities in a series of n = 2 and 3 Ruddlesden-Popper oxides, as part of an ongoing investigation in search of alternative solid electrolyte materials. Several different strategies were employed for the enhancement of …
Exploring Service Provider Perspectives On Facilitators And Barriers To Needle Exchange Program Participation By Females Who Inject Drugs., Tammi Alvey Thomas
Exploring Service Provider Perspectives On Facilitators And Barriers To Needle Exchange Program Participation By Females Who Inject Drugs., Tammi Alvey Thomas
Electronic Theses and Dissertations
As the opioid epidemic lingers on across the country, many areas have set up harm reduction strategies such as needle exchange programs (NEPs) to combat the long-term consequences of injection drug use (IDU). Males and females face a plethora of health issues associated with injection drug use such as human immunodeficiency virus (HIV) and hepatitis C. While males comprise the largest portion of the injection drug use population, most research is gender neutral, which makes it difficult to discern issues specifically related to females inhibiting our ability to design interventions and procedures targeted to address their needs. Females require varying …
Towards Long Term Colloid Suspension In A Vertically Rotated System., Md Mahmudur Rahman
Towards Long Term Colloid Suspension In A Vertically Rotated System., Md Mahmudur Rahman
Electronic Theses and Dissertations
Within a colloidal suspension gravity may compromise the observation of governing physical interactions, especially those that are weak and/or take significant time to develop. Conducting the experiment in a long-term microgravity environment is a viable option to negate gravitational effects, though significant resources are required to do so. While it may not be possible to simulate long-term microgravity terrestrially, particles can resist quick sedimentation in a confined suspension system rotating vertically with appropriate rotation speed. The goal of the investigation is to demonstrate the existence of long-term particle suspension regime for a certain colloidal suspension while characterizing colloidal behavior due …
Assessing The Role Of Arsenic Exposure And Mirna-186 In Skin Tumorigenesis And Chromosomal Instability., Angeliki Lykoudi
Assessing The Role Of Arsenic Exposure And Mirna-186 In Skin Tumorigenesis And Chromosomal Instability., Angeliki Lykoudi
Electronic Theses and Dissertations
Chronic arsenic exposure through drinking water is a global health issue, affecting more than 200 million people. Arsenic is a group I human carcinogen and causes chromosomal instability (CIN). Arsenic exposure is the second most cause of skin cancer after UV radiation. MiR-186 is overexpressed in arsenic-induced squamous cell carcinoma relative to premalignant hyperkeratosis. Predicted targets of miR-186 are cell cycle regulators. Thus, we hypothesize that miR-186 overexpression drives malignant transformation of HaCaT cells by induction of CIN. Stable clones of HaCaT transfected with pEP-miR-186 expression vector or empty vector were maintained under puromycin selection were exposed to 0 or …