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Experimental, Analytical, And Numerical Evaluation Of The Mechanical Properties Of The Brain Tissue, Aref Samadidooki Jun 2018

Experimental, Analytical, And Numerical Evaluation Of The Mechanical Properties Of The Brain Tissue, Aref Samadidooki

LSU Doctoral Dissertations

A true understanding of the mechanisms behind most of the brain diseases is still out of reach. For several years, the interest of scientists has been focused on the genetic and biological causes, however, recent studies unraveled the importance of the biomechanics of the brain growth, folding, impact resistance, and deformation on its pathological conditions. While, a wide range of different methods have been used for characterization of the mechanical properties of the brain at the tissue level, the obtained results from different studies are extremely scattered and sometimes in contrast to one another. Since the brain tissue is extremely …


Image-Based Modeling Of Flow Through Porous Media: Development Of Multiscale Techniques For The Pore Level, Timothy Wayne Thibodeaux Jan 2018

Image-Based Modeling Of Flow Through Porous Media: Development Of Multiscale Techniques For The Pore Level, Timothy Wayne Thibodeaux

LSU Doctoral Dissertations

Increasingly, imaging technology allows porous media problems to be modeled at microscopic and sub-microscopic levels with finer resolution. However, the physical domain size required to be representative of the media prohibits comprehensive micro-scale simulation. A hybrid or multiscale approach is necessary to overcome this challenge. In this work, a technique was developed for determining the characteristic scales of porous materials, and a multiscale modeling methodology was developed to better understand the interaction/dependence of phenomena occurring at different microscopic scales. The multiscale method couples microscopic simulations at the pore and sub-pore scales. Network modeling is a common pore-scale technique which employs …