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Investigating The Role Of The Caspase-6 Cleavage Fragment Of Mutant Huntingtin In Huntington Disease Pathogenesis, Jourdan A. Mckinnis
Investigating The Role Of The Caspase-6 Cleavage Fragment Of Mutant Huntingtin In Huntington Disease Pathogenesis, Jourdan A. Mckinnis
Honors Undergraduate Theses
Huntington disease (HD) is a devastating and fatal neurodegenerative disease. At the moment, no disease modifying therapies are available, with only symptomatic treatment offered to alleviate psychiatric and some types of motor deficits. As a result, many people will continue to suffer and die from this disease. Small molecule therapies have failed to provide benefit in HD, necessitating more complex gene therapy approaches and the identification of less traditional therapeutic targets. A previous study demonstrated that preventing cleavage of the huntingtin (HTT) protein, the protein that when mutated causes HD, by caspase 6 (C6) at amino acid 586 prevents the …