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Allosteric Regulation Of Caspase-6 Proteolytic Activity, Elih M. Velazquez-Delgado
Allosteric Regulation Of Caspase-6 Proteolytic Activity, Elih M. Velazquez-Delgado
Open Access Dissertations
Caspases are cysteine proteases best known for their controlling roles in apoptosis and inflammation. Caspase-6 has recently been shown to play a key role in the cleavage of neurodegenerative substrates that causes Huntington and Alzheimer's Disease, heightening interest in caspase-6 and making it a drug target. All thirteen human caspases have related specificities for binding and cleaving substrate, so achieving caspase-specific regulation at the active site has been extremely challenging if not impossible. We have determined the structures of four unliganded forms of caspase-6, which attain a novel helical structure not observed in any other caspases. In this conformation, rotation …
Risk Factors For Future Cardiac Diseases In Childhood Cancer Survivors, David C. Landy
Risk Factors For Future Cardiac Diseases In Childhood Cancer Survivors, David C. Landy
Open Access Dissertations
Background: With 12,000 children diagnosed with cancer annually in the United States and survival rates approaching 80%, the long-term health of childhood cancer survivors is an increasingly important concern. This is especially true given that over 70% of survivors develop a chronic health condition by 30 years after their original diagnosis. Cardiovascular diseases (CVD) are the most common non-cancer related complications. Although some risk factors for therapy-induced cardiovascular damage have been identified, their influence on longitudinal CVD risk is not well described, and therefore, their clinical utility is limited. While guidelines exist for protecting the long-term cardiovascular health of survivors, …