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Equipment Qualification Of Ion Mobility Spectrometry And Method Development And Validation For Pharmaceutical Equipment Cleaning Validation, Amy Lee Heiser

Masters Theses

Ion mobility spectrometry (IMS) instrumentation has been identified as a suitable technology for the detection and reporting of drug product and detergent residues from pharmaceutical manufacturing equipment. Ion mobility is not a new technology, but is entering the field of cleaning validation because of tightened requirements from the US Food and Drug Administration (FDA).

The purpose of this thesis is to outline a practical implementation of the analytical technique, Ion Mobility Spectrometry in a cleaning validation program. Ion Mobility Spectrometry (IMS) is fast and specific for the analysis of small organic molecules and has been gaining popularity in the pharmaceutical …

Direct Analysis Of Hops By Leaf Spray And Paper Spray Mass Spectrometry, Kari Blain

Masters Theses

The objective of this research is to develop a new and innovative method of hops analysis, which is much faster than standard testing methods, as well as reduce the amount of consumables and solvent used. A detailed discussion on the development of an ambient ionization mass spectrometry method called paper spray (PS-MS) and leaf spray (LS-MS) mass spectrometry will be presented. This research investigates the use of PS-MS and LS-MS techniques to determine the α- and β- acids present in hops. PS-MS and LS-MS provide a fast way to analyze hops samples by delivering data as rapidly as a UV-Vis …

Synthesis Of 1,1-Dialkyhydrazines And Their Hydroxyl Radical Degradation In Aqueous Environments, Benjamin F. Strong

Masters Theses

Determination of hydroxyl radical rate constants are essential to ensure adequate degradation of contaminants in wastewater. Hydrazines are an important class of organic contaminants and are the focus of this research. Ten 1,1-dialkylhydrazines are synthesized by the zinc reduction of the corresponding N-nitrosamines. Their hydroxyl radical rate constants are determined using the linear accelerator at the Notre Dame Radiation Laboratory at pH 4, 7, and 10.

Their rate constants are found to depend on the protonation state of the molecule. At pH 4 the molecules are fully protonated and hydrogen atom abstraction is favored from the alkyl chains. At …

Investigating The Biochemical Activity Of Some Flavonoids, Coumarins And Modified Gold-Nanoparticles As Anti-Breast-Cancer Agents, Amr Ezzat Mohamed Mahmoud

Dissertations

Polyphenols compounds are abundant natural products found in many plants as secondary metabolites. These compounds display many interesting pharmacological activities, which have motivated chemists over the years to explore them, and their synthetic derivatives, as potential drugs, especially anticancer drugs. Breast cancer is the most common cancer in women globally, and in the United States of America the estimated worldwide new breast cancer cases and the number of deaths are 1.38 million and 458 thousand, respectively. Currently in the USA there are 2.6 million women who have been treated for breast cancer, and the estimated number of deaths are 39,520 …

Investigation Of Saccharide Release Through Acidification, Sonication, Thermal, And Microwave Treatments, William K. Storck

Honors Theses

With diminishing fossil fuels, renewable sources are becoming much higher in demand. Algae are becoming an increasingly important source of biofuels. Production of biofuels from algae exceeds yields from every other source, most notably corn, per acre. It also provides a highly viable method of reusing carbon dioxide and does not compete with other crops for growth. The production of ethanol through fermentation requires the release of saccharides produced by the algae. The more saccharides extracted, the more ethanol can be produced. This project investigates for a more effective method of maximum saccharide release.

The purpose of this project is …

Interaction Of Pharmaceutical Compounds With Dissolved Organic Matter, Carlen Nigl Smith

Honors Theses

Highly prescribed pharmaceutical compounds and their metabolites used to treat conditions ranging from infections to depression are of environmental concern as these excreted compounds are increasingly appearing in wastewater influent. As pharmaceuticals enter treatment plants they also can interact with dissolved organic matter (DOM) present. This potential interaction between pharmaceutical compounds and DOM may inhibit the advanced oxidation process (AOP) based removal of drugs during water treatment. The focus of this research was to utilize multinuclear magnetic resonance and hydroxyl radical kinetics to assess whether an interaction between influent pharmaceuticals and DOM does occur, the extent of the interaction, and …

Optical And Electrochemical Sensors For The Detection Of Metal Ions And Nerve Gas Mimics Via Fluorescein And Coumarin Derivatives, Fasil Adefris Abebe

Dissertations

Trace element detection of metals, for example, iron, Copper and zinc, are important in biological systems and in the environment. Many of us are aware that our cells contain metal ions that are “tied” up in proteins. However, chelatable or “free” trace elements can also be found in small quantities, and can have a negative impact on our bodies. Despite the increasing surge in developing sensors for metals and nerve gas agents, efficient detection still remains a challenge. Among the various sensors developed so far, fluorescence sensors play an important role due to their simplicity. I design fluorescein-based chemosensors for …

Optical And Electrochemical Properties Of Monolayer Protected Gold Clusters Modified With Fluorophores, Mary Sajini Devadas

Dissertations

My research focused on the synthesis, characterization and the investigation of the optical and electrochemical properties of monolayer-protected quantum-sized gold clusters. Significant research attention was focused on the solution phase optical and electrochemical properties of these clusters. Highly monodisperse Au clusters with different types of ligands were successfully synthesized with sizes varying from 1 nm to 13 nm. These preformed gold clusters were modified with fluorophores and pseudo-rotaxanes for developing better nonlinear optical materials for sensing and biological imaging purposes. We have tried to focus on the interaction of the outer ligand shell, made up of –S-Au-S-Au-S- bonds, with the …