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The Effects Of A Comprehensive Post-Treatment Recovery Program For Breast Cancer Survivors, Keri Ann Hockett
The Effects Of A Comprehensive Post-Treatment Recovery Program For Breast Cancer Survivors, Keri Ann Hockett
USF Tampa Graduate Theses and Dissertations
Background: Breast cancer and its treatment often result in side effects that persist long after treatment has ended. The increased survival rate for breast cancer has allowed for the study of the physical and psychosocial symptoms that persist into the post-treatment period. Although research has tested various interventions and demonstrated improvement in some symptoms, no standard of care exists for management of symptoms in the post- treatment period as part of the continuum of care. Objective: The aim of this research was to examine the effects of a comprehensive recovery program of education, exercise, and support for breast cancer survivors …
Regulation Of Sparc Gene Expression By The Activator Protein 1 Transcription Factor, Joseph William Briggs
Regulation Of Sparc Gene Expression By The Activator Protein 1 Transcription Factor, Joseph William Briggs
Theses and Dissertations in Biomedical Sciences
Overexpression of the c-Jun proto-oncogene in MCF7 breast cancer cells results in a variety of phenotypic changes related to malignant progression including a shift to estrogen independent growth, increased cell motility and invasion. Concurrent with these phenotypic changes are alterations to cellular gene expression patterns. One gene that becomes highly upregulated is SPARC (secreted protein acidic and rich in cysteine). Increased SPARC expression is associated with malignant progression in a variety of different cancers, although little is known regarding the mechanisms of SPARC gene regulation. Therefore, the objectives of this study were: (1) to determine the mechanisms by which c-Jun …