Digital Commons Network^™

Power Systems Cascading Failure Analysis And Mitigation Using Discrete Events Systems Approach, Wasseem Al Rousan

Wayne State University Dissertations

A power system cascading failure can propagate through sequential tripping of components in the network. As a result, a complete or partial shutdown may occur. Many models were developed to understand the failure propagation mechanism at a higher abstract level and methods were implemented for failure mitigation. This work introduces a unified framework of modeling and mitigating cascading failures. Based on a Discrete Event Systems (DES) approach, a power system is modeled by an automaton via parallel composition of the sub-models of system components. A modified DES supervisory control (SC) strategies are introduced as a solution to mitigating cascading failures …

La Olla Y Los Patios: An Ethnography Of Place, Selfhood, Violence, And Rehabilitation In Bogotá, Andrés Romero

Wayne State University Dissertations

In the early hours of May 28, 2016, the mayor of Bogotá, along with the Colombian military and SpecialForces, seized the biggest olla or open-air drug market in Colombia at the time. The olla known as “El Bronx” was a three-block area in downtown Bogotá and where over 2,000 people found shelter under the authority of paramilitary affiliated crime bands controlling the city’s drug trade. Widely depicted by the media and the broader polity as an “inferno,” El Bronx was regarded as a space where those socially relegated outside of the human were encumbered by seemingly endless transgression and drug …

The Effect Of Acute And Chronic Arsenic Exposure On Malignant Transformation Of The Human Bronchial Epithelial Cell (Beas-2b), Bandar Almutairy

Wayne State University Dissertations

Arsenic (As3+), a metalloid abundant in the environment, is classified as a group I carcinogen associated with several common human cancers, including cancers in the lung, skin, bladder, liver, and prostate (Wei, Zhang & Tao, 2019b). The mechanisms of As3+-induced carcinogenesis had been extensively studied, and different mechanisms might be involved in various types of cancer (Wei, Zhang & Tao, 2019b). Recent studies showed that exposure to a high dose of arsenic is able to induce lung cancer. Moreover, arsenic activates oncogenic signaling pathways such as MAPKs, EGFR/RAS/RAF, PI3K/AKT, and JNK/STAT3 pathways as well as epigenetic alterations such as miRNAs …

A Program Of Race Betterment: The Emergence And Evolution Of Eugenic Ideas In Michigan, Branden Mceuen

Wayne State University Dissertations

Contemporary concerns with technologies like CRISPR and the proliferation of state laws restricting abortion have led people to wonder if we are witnessing a return of eugenics. I analyze the development and evolution of eugenic ideas and policies throughout the 20th century, using the state of Michigan as a frame of reference. In examining the eugenic theories and policies psychiatrists and physicians endorsed, I demonstrate that eugenics was a key component of preventive public medicine in the first two decades of the 20th century. I show how they educated the public on eugenics based on both environmentalist and hereditarian ideas …

White Teacher Attitudes Towards Their Experiences With Anti-Racist Initiatives, Rebecca Frances Reaume

Wayne State University Dissertations

The attitudes of white teachers become a critically important aspect of racism and its dismantling. White teachers work within the institutions that have power to inspire and empower students and they have the tendency to hold the structures of the dominant society within their behaviours and actions. This study embraces a mixed method research design through surveys and semi-structured interviews to explore the attitudes that white teachers have towards their experiences with anti-racist initiatives. Teachers are able to either replicate and sustain social patterns of white hegemony or act as agents of change in combat of racism. As a force …

The Arsenic Induced Endoplasmic Reticulum Stress Response Via The Activating Transcription Factor 6 In Human Bronchial Epithelial Beas-2b Cells, Priya Wadgaonkar

Wayne State University Dissertations

Arsenic is a well-known human carcinogen associated with a number of cancers, including lung cancers. We have previously shown that long-term exposure to an environmentally relevantconcentration of inorganic arsenic (As3+) leads to the malignant transformation of the BEAS-2B cells, and some of the transformed cells show cancer stem-like features (CSCs) with a significant upregulation of glycolysis and downregulation of mitochondrial oxidative phosphorylation. In the present report, we investigate the short-term effect of As3+ on the endoplasmic reticulum (ER) stress response—the “unfolded protein response (UPR)” and metabolism in human bronchial epithelial cell line BEAS-2B cells. Treatment of the cells with inorganic …

Memory For Emotional Expressions In Adults With Acquired Brain Injuries, Lauren Jeanne Radigan

Wayne State University Dissertations

Introduction: Memory for emotions expressed by others forms the continuity that characterizes unique and intimate relationships. Successful memory for facial expressions requires the ability to remember the identity of the face (who showed the emotion) as well as the emotion (which emotion they showed). People with acquired brain injuries (ABI) frequently have problems with social cognition, which involves understanding cues that communicate emotional and interpersonal information. ABI is commonly associated with trouble perceiving emotional expressions and recognizing the identity of faces; however, research on memory for emotions after ABI is sparse. This study examined cognitive and emotional characteristics that contribute …

Synthesis Of Molybdenum Containing Thin Films Using Organic Reducing Agents And Synthesis Of Magnesium Silyl Intermediate Complexes For Use In Atomic Layer Deposition, Michael David Overbeek

Wayne State University Dissertations

Thin films of a variety of materials have shown great potential in the fields of microelectronics, catalysis, and energy applications. Vapor deposition methods, including PVD and CVD, have been traditionally used as the primary method to deposit these thin films. However, these methods do not provide the necessary thickness uniformity and conformality needed for future uses of these thin films as they shrink to smaller dimensions. ALD provides a high degree of uniformity and conformality due to the intrinsic nature of the self-limited reaction mechanism of an ALD process.

The research herein focuses on two metals that have untapped potential …

The Development Of Fundamental Insights Into The Electronic Behaviors Of Next-Generation Materials, Sydney Lavan

Wayne State University Dissertations

We develop the fundamental mechanistic understanding of the microscopic behavior of three next generation materials: antiferroelectrics, hybrid perovskites and metal organic frameworks. These materials have the potential to be used in energy and light related applications which could provide a solution for the energy efficiency challenges we face in todays society. Ideally we need to begin to bridge the gap of developing candidate materials that possess high power density and high energy density. The first step in bridging this gap is understanding how the material influ- ences its structure and thus the properties and performance. We leverage vibrational spectroscopy and …

Lepton Flavor Violation And Effective Field Theories, Renae Conlin

Wayne State University Dissertations

The Standard Model is believed to be a low energy effective theory of some completetheory at higher energies. This is already evidenced in the observation of neutrino oscillations. Standard Model processes conserve the lepton flavor quantum numbers. Adding massive neutrinos to the Standard Model, the branching ratios of lepton flavor violating processes are found to be incredibly small. For example, a process μ → eγ has a branching ratio order ∼ 10^−54. These tiny branching ratios of lepton flavor violating processes indicate that they are especially clean areas to look for beyond the Standard Model physics. Any observed flavor violation …

Labor Logs In A Multimodal Curriculum: Revealing Valuable Assessment Practices In Technical Communication And First-Year Writing Courses, Suzette Bristol

Wayne State University Dissertations

This project discusses the creation and implementation of labor logs in multimodal curricula in two levels of writing courses and how these labor logs support students’ development of meta-awareness through reflection-in-action (Yancey, 1998). Labor logs create a space for students to focus on in the moment recognition, or monitoring, of what takes place as they work through a project (VanKooten, 2016; Trimble and Jankens, 2019). By turning the focus of labor-based assessment (Inoue, 2019) to multimodal projects, this project clarifies the work that labor logs and multimodal pedagogies do in first-year writing and technical communication courses: indicating for students a …

Segmentation Of Intracranial Structures From Noncontrast Ct Images With Deep Learning, Evan Porter

Wayne State University Dissertations

Presented in this work is an investigation of the application of artificially intelligent algorithms, namely deep learning, to generate segmentations for the application in functional avoidance radiotherapy treatment planning. Specific applications of deep learning for functional avoidance include generating hippocampus segmentations from computed tomography (CT) images and generating synthetic pulmonary perfusion images from four-dimensional CT (4DCT).A single institution dataset of 390 patients treated with Gamma Knife stereotactic radiosurgery was created. From these patients, the hippocampus was manually segmented on the high-resolution MR image and used for the development of the data processing methodology and model testing. It was determined that …

Constructing A Well-Being: Exploring Knowledge Construction In Dbt Skills Training Using Art And Activity Theory, Elizabeth Bailey

Wayne State University Dissertations

Through Arts-based Research, constructed within the theoretical basis of the Activity System, participants engaged with dialectical behavior therapy (DBT) program content to develop a cohesive and meaningful project. Participants are conceptualized as reliable experts in their own experience, and as active agents of knowledge construction. Participants generate profound and relevant insights into their experiences – insights that can enhance DBT practice, expand research methodology, and build conceptual connections across theories. The Arts-based Activity System offers a theoretically-backed methodology that can disrupt the harmful parallels between the development of the disorders DBT is intended to treat and the dominant research paradigm …

Development Of New Photochemical Tools For Applications In Cancer Research And Enzymatic Signaling, Nicholas Paul Toupin

Wayne State University Dissertations

Photochemical tools empower researchers to act with precision and control over the cellular environment through production of reactive oxygen species (ROS), targeted drug delivery, and modulation of enzymatic activity. These molecular tools use light as a readily available, biorthogonal reagent for initiating advantageous light-activated reactions. Using light in this way allows researchers to affect the cellular environment in specific ways with high spatio-temporal control. This dissertation focuses on expanding the applications of, mostly Ru(II)-based, photoactivated chemicals. Complexes of this type are able to act as photosensitizers in photodynamic therapy (PDT), as photocages (PCT), or as dual-action compounds capable of both …

The Experiences Of Libyan Students In U.S. Schools: Fathers' Perspectives On Issues And Challenges, Ssalah Hrhor

Wayne State University Dissertations

The goal of this study was to gain a better understanding of children's challenges in American schools from the perspective of their fathers. The research investigates how parents perceive and respond to the challenges that their children face in American schools. It also aims to provide a clear understanding of how Libyan emergent bilingual students are influenced by culture and identity. The first chapter discusses the importance of this research in understanding the difficulties that Libyan students face in American schools. Vygotsky's sociocultural theory (1978) is explained in Chapter 2. The theoretical framework is based on Vygotsky's socio-cultural theory, specifically …

Correlations And Dynamic Fluctuations In High Energy Collisions, Zoulfekar Mazloum

Wayne State University Dissertations

Is thermalization necessary for hydrodynamic flow in nuclear collisions? The discovery of flow-like azimuthal correlations in pA and high-multiplicity pp collisions raises profound questions about the onset of collective flow and its relation to hydrodynamics. We seek independent experimental information on the degree of thermalization in order to identify those hydrodynamic collision systems in which flow is sensitive to equilibrium QCD properties. We aim to develop a protocol for identifying the degree of thermalization using a combination of momentum and multiplicity correlation. To study the effect ofthermalization on these correlations, we use Boltzmann equation in the relaxation time approximation with …

The Importance Of Protein Context In Spinocerebellar Ataxia Type 3, Sean Luis Johnson

Wayne State University Dissertations

Spinocerebellar Ataxia Type 3 (SCA3) is a member of the family of polyglutamine (polyQ) neurodegenerative disorders that includes Huntington's Disease and several other SCAs. SCA3, the most common dominant ataxia in the world, is caused by polyQ tract expansion in the protein, ataxin-3. How SCA3 occurs and how to treat it remain unresolved issues. The primary culprit of toxicity in all polyQ diseases is the glutamine repeat: its abnormal expansion leads to neuronal dysfunction and death. With that said, there is indisputable evidence that the way polyQ-dependent toxicity presents—areas impacted, cellular processes perturbed—is predicated in large part on regions outside …

Photophysics Of Metalloporphyrins Strongly Coupled To Cavity Photons, Aleksandr Avramenko

Wayne State University Dissertations

This dissertation will discuss the photophysics of metalloporphyrins, mainly CuTPP, ZnTPP, and H2TPP under strong light-matter coupling conditions. Strong light-matter coupling was achieved by embedding the previously mentioned chromophores into a spun coated PMMA polymer coating which is then incorporated as a spacer layer in a FabryPérot nano-cavity. The cavity thickness is chosen so that the cavity photon is of similar energy as the B, or Soret transition (2nd excited state) of the porphyrin molecule. The exchange of energy between the cavity photon and the molecular mode leads to the formation of polariton states.

Increasing the concentration of the molecules …

Deconstructing Brown Adipocyte Neogenesis In Brown And White Adipose Tissue, Rayanne Burl

Wayne State University Dissertations

Global incidence of Type 2 Diabetes (T2D) has reached epidemic proportions, and increasing evidence indicates that dysfunctional adipose tissue is an important contributor to the pathogenesis of T2D. Expanding brown adipocyte (BA) populations within adipose tissues through adrenergic activation improves energy balance and insulin sensitivity. In order to exploit this remodeling of adipose tissue for therapeutic benefit, we need to understand the mechanisms by which adrenergic signaling expand populations of BAs in vivo. These studies utilized single-cell RNA-sequencing and transgenic mouse models, in combination with single-molecule fluorescence in situ hybridization (smFISH) and immunoistochemical analysis, to study BA neogenesis in vivo. …

Jet Substructure Measurements In Proton-Proton And Proton-Gold Collisions, Isaac Arthur Mooney

Wayne State University Dissertations

Observing a modification of high-energy probes in the hot nuclear environment created by ultrarelativistic heavy-ion collisions is critical for understanding the microscopic structure of the QCD medium. However, before a modification can be observed, the probes must be calibrated. For this reason, measurements of jet observables in vacuum (pp collisions) and in the presence of cold nuclear matter (pAu collisions) are presented, which will allow for future comparison of jet substructure measurements in AuAu to these baseline measurements. \parData from the STAR detector on the Relativistic Heavy Ion Collider at Brookhaven National Laboratory are used for both analyses. The pp …

Kinase-Catalyzed Labeling To Identify Kinase-Substrate Pairs Using Γ-Phosphate Modified Atp Analogs, Rachel Beltman

Wayne State University Dissertations

Post-translational modifications (PTMs) are responsible for a variety of cellular processes. One such PTM is protein phosphorylation, which is catalyzed by kinases. Kinase enzymes play important roles in cellular signaling pathways, but dysregulation of kinase-mediated events results in the formation of diseases, which make kinases favorable drug targets. To uncover the role kinases play in the development of diseases, kinase-mediated cellular events need to be better understood. The current gap in the field is the lack of tools available to identify the kinase that is responsible for specific phosphorylation events within the cell. To improve the gap in the field, …

Novel Interaction Of Cxcr4 And Pi4kiiiα In Prostate Cancer, Barani Govindarajan

Wayne State University Dissertations

The CXCR4-CXCL12 chemokine signaling axis plays a key role in migration and bone metastasis in prostate cancer (PC). Androgens regulate CXCR4 expression and its receptor activation in lipid-raft micro domains of PC cells, resulting in higher protease expression and invasion. In order to identify some novel CXCR4 co-regulators associated within the lipid-raft, a SILAC (Stable isotope labeling using amino acid in cell culture)-based proteomic analysis was performed with PC3 stable cell-lines over-expressing or knocking-down CXCR4. Phosphatidylinositol 4-kinase III alpha (PI4KIIIα or PI4KA) and SAC1 lipid phosphatase were identified as candidate proteins enriched in CXCR4 expressing cells. PI4KA is an evolutionarily …

Backdoor To Essentialism? Genetic Ancestry Testing And The Social Deconstruction Of Whiteness, Whitney Hunt

Wayne State University Dissertations

Towards the turn of the 21st century, spawned in part by the Human Genome Project, ideas about race and ethnicity shifted away from the essentialist belief that humans can be grouped into discrete, biologically relevant racial groups. More recently however, genetic ancestry testing (GAT) has exploded in popularity, as individuals seek to identify their ancestry and/or health profiles through genetic testing. Genetic testing commercials implicitly promote the essentialist belief that racial and ethnic identities are embedded in genes by portraying images of people altering travel plans, checking a different racial category on a survey, or trading in bagpipes for lederhosen, …

Non-Perturbative Processes In Standard Model \& New Physics: From Standard Calculations To Machine Learning, Cody Michael Grant

Wayne State University Dissertations

I calculated non-perturbative processes to study the Standard Model and probe areas of new physics. I found that invisible decays of heavy mesons are not dominated by the leading order contribution in the Standard Model. I argue that this affects neutrino mass constraints and avenues for discovering new physics, such as dark photons. In addition to this, I used a novel approach to approximate a semileptonic form factor with an artificial neural network (ANN). Comparing the results from the ANN to common phenomenological parameterizations, and using it to set a lower bound constraint on the CKM matrix element, $V_{cd}$. Finally, …

Adversarial Machine Learning For Advanced Medical Imaging Systems, Xin Li

Wayne State University Dissertations

Although deep neural networks (DNNs) have achieved significant advancement in various challenging tasks of computer vision, they are also known to be vulnerable to so-called adversarial attacks. With only imperceptibly small perturbations added to a clean image, adversarial samples can drastically change models’ prediction, resulting in a significant drop in DNN’s performance. This phenomenon poses a serious threat to security-critical applications of DNNs, such as medical imaging, autonomous driving, and surveillance systems. In this dissertation, we present adversarial machine learning approaches for natural image classification and advanced medical imaging systems.

We start by describing our advanced medical imaging systems to …

Nonparent-Friendly Work Climate & Parental Role Value: An Updated Approach To Understanding Nonparent Work Experiences, Andrew Lutz

Wayne State University Dissertations

First, the present study entails a theoretically guided examination of relationships between nonparent-friendly organizational climate (NPFC) and important outcomes among nonparent workers. Second, the present study explores the role of social-identity theory in understanding nonparent work experiences by examining and comparing the function (i.e., moderation effect sizes) of parental role values and parental expectations (i.e., childfree status) on relationships between NPFC and outcomes including affective commitment. Third, the present study compares the relevance of NPFC and singles-friendly culture in the prediction of outcomes among nonparent workers. Lastly, the present study examines the potential role of intersectionality of nonparental role and …

Study Of Zyomogen Granule Movement Along Actin Filaments Using A Single Beam Optical Trap, Justin James Raupp

Wayne State University Dissertations

Zymogen granules are enzymatic vesicles in the pancreas. The surface of these zymogen granules (ZGs) has several different kinds of myosin molecules, such as myosin 1c, 6, 5c, and 7b. These molecular motors may contribute to ZG transportation in cells. To understand the molecular motors involved in the vesicle trafficking, we observed the in vitro motility of purified ZGs from rat pancreas and examined the stepping behavior and force that is generated using a single beam optical trap. To be involved in trafficking, molecular motors have certain characteristics, a high duty ratio and the ability to move continuously along actin …

Exposure To Family Violence And Early Sexual Engagement: Potential Disruptors To Intimacy Development In Girls' Early To Middle Adolescent Close Friendships, Jami C. Pittman

Wayne State University Dissertations

Informed by theories of interpersonal development, this study evaluates whether two known threats to psychosocial health – exposure to family violence (EFV) and early sexual engagement (ESE) – are associated with adolescent girls’ intimacy development with close same-sex friends. A sample of metropolitan-area, mostly Black and African American (77%) girls (N = 93; Mage = 12.5) provided three waves of longitudinal data over 18 months (T1 – T3), spanning early to middle adolescence. Multilevel models were used to examine changes in girls’ close friendships, including the number of closest same-sex friends and quality of best same-sex friendship. Cumulative EFV and …

A C0 Finite Element Method For The Biharmonic Problem In A Polygonal Domain, Charuka Dilhara Wickramasinghe

Wayne State University Dissertations

This dissertation studies the biharmonic equation with Dirichlet boundary conditions in a polygonal domain. The biharmonic problem appears in various real-world applications, for example in plate problems, human face recognition, radar imaging, and hydrodynamics problems. There are three classical approaches to discretizing the biharmonic equation in the literature: conforming finite element methods, nonconforming finite element methods, and mixed finite element methods. We propose a mixed finite element method that effectively decouples the fourth-order problem into a system of one steady-state Stokes equation and one Poisson equation. As a generalization to the above-decoupled formulation, we propose another decoupled formulation using a …

Childhood Adversity And Alexithymia: Implications For Health Status In An Urban Police Sample, Christopher P. Urbanik

Wayne State University Dissertations

American law enforcement is regarded as one of the most stressful occupations in the United States, involving repeated exposure to threatening or challenging encounters and the risk of severe injury and death. A voluminous literature has documented various psychophysiological implications of police stress, including morbidity and premature mortality. Adverse childhood experiences (ACEs) are potentially traumatic stressors during one’s formative years, such as abuse, neglect, and household violence and dysfunction. ACEs have been linked to increased mental and physical health risks, yet ACEs have not been studied in police officers. Given the increase in the level of stress experienced by today’s …