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Robust Computational Tools For Multiple Testing With Genetic Association Studies, William L. Welbourn Jr.
Robust Computational Tools For Multiple Testing With Genetic Association Studies, William L. Welbourn Jr.
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
The mapping of the human genome and the completion of the Human HapMap project over the past decade have significantly altered how research is conducted with respect to the genetic epidemiology of human disease. Study designs and analytic approaches have evolved rapidly from investigations involving relatively few targeted candidate genes to hypothesis-free genome-wide association studies, where thousands – and now even millions – of single molecular mutations are simultaneously analyzed to identify regions of the genome that may influence disease. As laboratory techniques continue to improve and costs decrease, the volume of genetic data will inexorably rise, and robust tools …
Evaluating The Computational Efficiency Of Xfbat And Fbat For Family Based Studies, Yanwei Ouyang
Evaluating The Computational Efficiency Of Xfbat And Fbat For Family Based Studies, Yanwei Ouyang
All Graduate Plan B and other Reports, Spring 1920 to Spring 2023
Family-based study designs are often employed when investigating the genetic causes of complex disease. While the transmission disequilibrium test (TDT) and its extensions were developed to use family data for assessing linkage between a known genetic marker and a disease-causing gene, the so-called FBAT approach proposed by Rabinowitz and Laird (2000) effectively subsumes these family-based procedures as special cases. FBAT is fully conditional, but its implementation in the freely available FBAT software package uses a large-sample distributional approximation to compute p-values. The exact distribution for FBAT can be enumerated, but doing so explicitly is computationally intensive, particularly for relatively larger …
The Effect Of Item Format On Computation Subtest Scores Of Standardized Mathematics Achievement Tests, Larry Carcelli
The Effect Of Item Format On Computation Subtest Scores Of Standardized Mathematics Achievement Tests, Larry Carcelli
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
The effect on childrens' scores of different item formats used in standardized mathematics achievement tests was investigated. Second grade students were given a mathematics computation test using formats derived from five standardized achievement tests. Identical content was tested with each format. Differences in test scores between types of formats were statistically significant at p < .001 (F = 45.25). These results indicate that what a student appears to know is substantially influenced by the format of the particular test used in measuring achievement. These differences are not accounted for by the normative scaling of the different tests. Greater attention should be given to the effect of test item format in selecting and administering achievement tests.