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2024

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Inter-Institutional Analysis Of Skin Of Color Representation In Dermatological Lecture Content At Md And Do Medical Schools, Oluwafunke O. Ogunremi, Blake Fredericksen, John Komas, Sana F. Ismail, Siri Knusten-Larson, Valeriy Kozmenko, Afia Albin Dec 2024

Inter-Institutional Analysis Of Skin Of Color Representation In Dermatological Lecture Content At Md And Do Medical Schools, Oluwafunke O. Ogunremi, Blake Fredericksen, John Komas, Sana F. Ismail, Siri Knusten-Larson, Valeriy Kozmenko, Afia Albin

Student Publications

The purpose of this study was to analyze the lecture materials provided in medical schools through a diversity lens. Skin pathologies manifest distinctively on various shades of skin and physicians must be equipped with the proper knowledge to identify and diagnose these conditions accurately and promptly. For most medical students, images in prominent textbooks and lecture slides are their first encounter with disease presentations. Therefore, it is important to analyze the diversity of skin tones in the content that is being delivered. Specifically, the use of images featuring darker skin tones compared to those depicting lighter skin tones. This study …


Saponin Tql1055 Adjuvant-Containing Vaccine Confers Protection Upon Mycobacterium Tuberculosis Challenge In Mice, Mushtaq Ahmed, Eric Farris, Rosemary V Swanson, Shibali Das, Yan Yang, Tyler Martin, Shabaana A Khader Dec 2024

Saponin Tql1055 Adjuvant-Containing Vaccine Confers Protection Upon Mycobacterium Tuberculosis Challenge In Mice, Mushtaq Ahmed, Eric Farris, Rosemary V Swanson, Shibali Das, Yan Yang, Tyler Martin, Shabaana A Khader

2020-Current year OA Pubs

Tuberculosis (TB), caused by the intracellular pathogen


The Association Of Caregiver Attitudes, Information Sources, And Trust With Hpv Vaccine Initiation Among Adolescents, Akila Anandarajah, Thembekile Shato, Sarah Humble, Alan R Barnette, Heather M Brandt, Lisa M Klesges, Vetta L Sanders Thompson, Michelle I Silver Dec 2024

The Association Of Caregiver Attitudes, Information Sources, And Trust With Hpv Vaccine Initiation Among Adolescents, Akila Anandarajah, Thembekile Shato, Sarah Humble, Alan R Barnette, Heather M Brandt, Lisa M Klesges, Vetta L Sanders Thompson, Michelle I Silver

2020-Current year OA Pubs

This study described caregiver attitudes and the information sources they access about HPV vaccination for adolescents and determined their influence on human papillomavirus (HPV) vaccination initiation. An online survey was administered to 1,016 adults in July 2021. Participants were eligible if they were the caregiver of a child aged 9-17 residing in Mississippi, Arkansas, Tennessee, Missouri, and select counties in Southern Illinois. Multivariate logistic regression was used to estimate the association of caregiver attitudes and information sources with HPV vaccination. Information from doctors or healthcare providers (87.4%) and internet sources other than social media (31.0%) were the most used sources …


Transcription Factor Expression Landscape In Drosophila Embryonic Cell Lines, Robert A. Drewell, Daniel Klonaros, Jacqueline Dresch Dec 2024

Transcription Factor Expression Landscape In Drosophila Embryonic Cell Lines, Robert A. Drewell, Daniel Klonaros, Jacqueline Dresch

Biology

Background: Transcription factor (TF) proteins are a key component of the gene regulatory networks that control cellular fates and function. TFs bind DNA regulatory elements in a sequence-specific manner and modulate target gene expression through combinatorial interactions with each other, cofactors, and chromatin-modifying proteins. Large-scale studies over the last two decades have helped shed light on the complex network of TFs that regulate development in Drosophila melanogaster. Results: Here, we present a detailed characterization of expression of all known and predicted Drosophila TFs in two well-established embryonic cell lines, Kc167 and S2 cells. Using deep coverage RNA sequencing approaches we …


A Genotyping Array For The Globally Invasive Vector Mosquito, Aedes Albopictus, Luciano Veiga Cosme, Margaret Corley, Thomas Johnson, Dave W. Severson, Guiyun Yan, Xiaoming Wang, Nigel Beebe, Andrew Maynard, Mariangela Bonizzoni, Ayda Khorramnejad, Ademir Jesus Martins, José Bento Pereira Lima, Todd P. Livdahl Dec 2024

A Genotyping Array For The Globally Invasive Vector Mosquito, Aedes Albopictus, Luciano Veiga Cosme, Margaret Corley, Thomas Johnson, Dave W. Severson, Guiyun Yan, Xiaoming Wang, Nigel Beebe, Andrew Maynard, Mariangela Bonizzoni, Ayda Khorramnejad, Ademir Jesus Martins, José Bento Pereira Lima, Todd P. Livdahl

Biology

Background: Although whole-genome sequencing (WGS) is the preferred genotyping method for most genomic analyses, limitations are often experienced when studying genomes characterized by a high percentage of repetitive elements, high linkage, and recombination deserts. The Asian tiger mosquito (Aedes albopictus), for example, has a genome comprising up to 72% repetitive elements, and therefore we set out to develop a single-nucleotide polymorphism (SNP) chip to be more cost-effective. Aedes albopictus is an invasive species originating from Southeast Asia that has recently spread around the world and is a vector for many human diseases. Developing an accessible genotyping platform is essential in …


Mobile Money Innovations, Income Inequality And Gender Inclusion In Sub-Saharan Africa, Simplice A. Asongu, Peter Agyemang-Mintah, Joseph Nnanna, Yolande E. Ngoungou Dec 2024

Mobile Money Innovations, Income Inequality And Gender Inclusion In Sub-Saharan Africa, Simplice A. Asongu, Peter Agyemang-Mintah, Joseph Nnanna, Yolande E. Ngoungou

All Works

This study assesses the role of mobile money innovations on income inequality and gender inclusion in 42 sub-Saharan African countries from 1980 to 2019 using interactive quantile regressions. It finds that, first, income inequality unconditionally reduces the involvement of women in business and politics. Second, mobile money innovations interact with income inequality to have a positive impact on women in business and politics. Third, the net effects of mobile money innovations on gender inclusion through income inequality are consistently negative. Fourth, as the positive conditional or interactive effects and negative net effects are consistent across the conditional distribution of gender …


University ‘Pay-For-Grades’: The Bait And Switch Search Engine Optimization Strategies Of Contract Cheating Websites In The United States, Timothy M. Daly, James C. Ryan Dec 2024

University ‘Pay-For-Grades’: The Bait And Switch Search Engine Optimization Strategies Of Contract Cheating Websites In The United States, Timothy M. Daly, James C. Ryan

All Works

This paper presents the first systematic investigation into the search engine optimization practices of major contract cheating websites in the United States. From a business perspective, visibility in organic search engine results is considered one of the top client recruitment tools. The current understanding of student recruitment strategies by these companies remains largely unexplored in both academic literature and popular press. Replicating the business research practices used in the search engine optimization industry, comprehensive search engine ranking and traffic data was obtained for the 38 largest contract cheating websites in the US. The overall objective was to illuminate the strategies …


In Their Own Voices: A Nationwide Study Of Students’ Attitudes Towards The Implementation Of Smart Learning Environments In Uae Schools, Maria Efstratopoulou, Maxwell Peprah Opoku, Aizhan Shomotova, Christina Davison, Abdulrafi Jaffarul, Aalya Mesmar Dec 2024

In Their Own Voices: A Nationwide Study Of Students’ Attitudes Towards The Implementation Of Smart Learning Environments In Uae Schools, Maria Efstratopoulou, Maxwell Peprah Opoku, Aizhan Shomotova, Christina Davison, Abdulrafi Jaffarul, Aalya Mesmar

All Works

A smart learning environment (SLE) encompasses the use of advanced technology and smart pedagogical teaching skills tailored to suit students with diverse learning needs. In recent years, some countries, such as the United Arab Emirates (UAE), have formulated policies to implement SLE in their education systems. Since students are the intended beneficiaries of SLE policy, it is crucial to explore their perceptions of its implementation in a novel context. Therefore, this study explored the attitudes of students towards the implementation of SLE in the UAE. To conduct this investigation, 1857 secondary school students (grades 7 and 12) were recruited nationwide. …


Sustainable Energysense: A Predictive Machine Learning Framework For Optimizing Residential Electricity Consumption, Murad Al-Rajab, Samia Loucif Dec 2024

Sustainable Energysense: A Predictive Machine Learning Framework For Optimizing Residential Electricity Consumption, Murad Al-Rajab, Samia Loucif

All Works

In a world where electricity is often taken for granted, the surge in consumption poses significant challenges, including elevated CO2 emissions and rising prices. These issues not only impact consumers but also have broader implications for the global environment. This paper endeavors to propose a smart application dedicated to optimizing the electricity consumption of household appliances. It employs Augmented Reality (AR) technology along with YOLO to detect electrical appliances and provide detailed electricity consumption insights, such as displaying the appliance consumption rate and computing the total electricity consumption based on the number of hours the appliance was used. The application …


Leadership Potential And Self-Perceived Employability Of Undergraduate Students In The United Arab Emirates, Aizhan Shomotova, Tatiana Karabchuk, Ali Ibrahim Dec 2024

Leadership Potential And Self-Perceived Employability Of Undergraduate Students In The United Arab Emirates, Aizhan Shomotova, Tatiana Karabchuk, Ali Ibrahim

All Works

One of the main challenges facing higher education institutions (HEIs) is developing students’ employability skills, such as leadership. The earlier students acquire leadership skills, the higher their self-perceived employability (SPE) is upon graduation. Understanding how leadership is associated with SPE can help HEIs provide better leadership development programmes to increase SPE so that students pursue sustainable employment after graduation and use their leadership skills successfully in the workplace. Currently, there is a scarcity of published research on how youth leadership potential (LP) impacts SPE among undergraduate students at HEIs in the United Arab Emirates (UAE) and the Arab region in …


Asthma Prevalence Among United States Population Insights From Nhanes Data Analysis, Sarya Swed, Bisher Sawaf, Feras Al-Obeidat, Wael Hafez, Amine Rakab, Hidar Alibrahim, Mohamad Nour Nasif, Baraa Alghalyini, Abdul Rehman Zia Zaidi, Lamees Alshareef, Fadel Alqatati, Fathima Zamrath Zahir, Ashraf I. Ahmed, Mulham Alom, Anas Sultan, Abdullah Almahmoud, Agyad Bakkour, Ivan Cherrez-Ojeda Dec 2024

Asthma Prevalence Among United States Population Insights From Nhanes Data Analysis, Sarya Swed, Bisher Sawaf, Feras Al-Obeidat, Wael Hafez, Amine Rakab, Hidar Alibrahim, Mohamad Nour Nasif, Baraa Alghalyini, Abdul Rehman Zia Zaidi, Lamees Alshareef, Fadel Alqatati, Fathima Zamrath Zahir, Ashraf I. Ahmed, Mulham Alom, Anas Sultan, Abdullah Almahmoud, Agyad Bakkour, Ivan Cherrez-Ojeda

All Works

Asthma is a prevalent respiratory condition that poses a substantial burden on public health in the United States. Understanding its prevalence and associated risk factors is vital for informed policymaking and public health interventions. This study aims to examine asthma prevalence and identify major risk factors in the U.S. population. Our study utilized NHANES data between 1999 and 2020 to investigate asthma prevalence and associated risk factors within the U.S. population. We analyzed a dataset of 64,222 participants, excluding those under 20 years old. We performed binary regression analysis to examine the relationship of demographic and health related covariates with …


Heritagutopia: A New Utopian Paradigm, Luca Donner, Francesca Sorcinelli Dec 2024

Heritagutopia: A New Utopian Paradigm, Luca Donner, Francesca Sorcinelli

All Works

The progress of humanity has always, and sometimes even unconsciously, been confronted with the concept of utopia at the social, economic, political, and urban level. The strength of every utopian vision lies in the disruptive factor inherent in the idea of metamorphosis of the status quo. In the urban context, it represents the pillar on which the vision of modern society and its city are based and understood as potential and progress for mankind. Authors such as Bauman, Bloch, Calvino, More, Mumford, Tafuri, and others, have formed the theoretical framework of the dialectic on which this study is based. As …


The Effects Of Short-Term, Progressive Exercise Training On Disease Activity In Smouldering Multiple Myeloma And Monoclonal Gammopathy Of Undetermined Significance: A Single-Arm Pilot Study, A. Emery, S. Moore, J. Crowe, J. Murray, O. Peacock, D. Thompson, F. Betts, S. Rapps, L. Ross, D. Rothschild-Rodriguez, A. A. Echarri, R. Davies, R. Lewis, D. X. Augustine, A. Whiteway, Z. Afzal, J. L. J. Heaney, M. T. Drayson, J. E. Turner, John P. Campbell Dec 2024

The Effects Of Short-Term, Progressive Exercise Training On Disease Activity In Smouldering Multiple Myeloma And Monoclonal Gammopathy Of Undetermined Significance: A Single-Arm Pilot Study, A. Emery, S. Moore, J. Crowe, J. Murray, O. Peacock, D. Thompson, F. Betts, S. Rapps, L. Ross, D. Rothschild-Rodriguez, A. A. Echarri, R. Davies, R. Lewis, D. X. Augustine, A. Whiteway, Z. Afzal, J. L. J. Heaney, M. T. Drayson, J. E. Turner, John P. Campbell

Research outputs 2022 to 2026

Background: High levels of physical activity are associated with reduced risk of the blood cancer multiple myeloma (MM). MM is preceded by the asymptomatic stages of monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM) which are clinically managed by watchful waiting. A case study (N = 1) of a former elite athlete aged 44 years previously indicated that a multi-modal exercise programme reversed SMM disease activity. To build from this prior case study, the present pilot study firstly examined if short-term exercise training was feasible and safe for a group of MGUS and SMM patients, and secondly …


Accounting For Albedo Change To Identify Climate-Positive Tree Cover Restoration, Natalia Hasler, Christopher A. Williams, Vanessa Carrasco Denney, Peter W. Ellis, Surendra Shrestha, Drew E. Terasaki Hart, Nicholas H. Wolff, Samantha Yeo, Thomas W. Crowther, Leland K. Werden, Susan Cook-Patton Dec 2024

Accounting For Albedo Change To Identify Climate-Positive Tree Cover Restoration, Natalia Hasler, Christopher A. Williams, Vanessa Carrasco Denney, Peter W. Ellis, Surendra Shrestha, Drew E. Terasaki Hart, Nicholas H. Wolff, Samantha Yeo, Thomas W. Crowther, Leland K. Werden, Susan Cook-Patton

Geography

Restoring tree cover changes albedo, which is the fraction of sunlight reflected from the Earth’s surface. In most locations, these changes in albedo offset or even negate the carbon removal benefits with the latter leading to global warming. Previous efforts to quantify the global climate mitigation benefit of restoring tree cover have not accounted robustly for albedo given a lack of spatially explicit data. Here we produce maps that show that carbon-only estimates may be up to 81% too high. While dryland and boreal settings have especially severe albedo offsets, it is possible to find places that provide net-positive climate …


Housing Insecurity Among Black Women Surviving Intimate Partner Violence During The Covid-19 Pandemic: An Intersectional Qualitative Approach, Tiara C. Willie, Sabriya L. Linton, Shannon Whittaker, Karlye A. Phillips, Deja Knight, Mya C. Gray, Gretta Gardner, Nicole Overstreet Dec 2024

Housing Insecurity Among Black Women Surviving Intimate Partner Violence During The Covid-19 Pandemic: An Intersectional Qualitative Approach, Tiara C. Willie, Sabriya L. Linton, Shannon Whittaker, Karlye A. Phillips, Deja Knight, Mya C. Gray, Gretta Gardner, Nicole Overstreet

Psychology

Background: Housing instability is highly prevalent among intimate partner violence (IPV) survivors, and the coupling consequences of structural racism, sexism, classism, and the COVID-19 pandemic, may create more barriers to safe and adequate housing, specifically for Black women IPV survivors. In particular, the consequences of the COVID-19 pandemic had the potential to amplify disadvantages for Black women IPV survivors, yet very little research has acknowledged it. Therefore, the current study sought to assess the experiences of housing insecurity among Black women experiencing intimate partner violence (IPV) while navigating racism, sexism, and classism during the COVID-19 pandemic. Methods: From January to …


Social Capital And Changes Of Psychologic Distress During Early Stage Of Covid-19 In New Orleans, Kimberly Wu, Erica Doe, Gabriella D. Roude, Jasmine Wallace, Samantha Francois, Lisa Richardson, Katherine P. Theall Dec 2024

Social Capital And Changes Of Psychologic Distress During Early Stage Of Covid-19 In New Orleans, Kimberly Wu, Erica Doe, Gabriella D. Roude, Jasmine Wallace, Samantha Francois, Lisa Richardson, Katherine P. Theall

Psychology

Here we report on the relationship between measures of social capital, and their association with changes in self-reported measures of psychological distress during the early period of the COVID-19 pandemic. We analyze data from an existing cluster randomized control trial (the Healthy Neighborhoods Project) with 244 participants from New Orleans, Louisiana. Changes in self-reported scores between baseline (January 2019–March 2020) and participant’s second survey (March 20, 2020, and onwards) are calculated. Logistic regression is employed to examine the association between social capital indicators and measures of psychological distress adjusting for key covariates and controlling for residential clustering effects. Participants reporting …


Metaverse-Powered Basic Sciences Medical Education: Bridging The Gaps For Lower Middle-Income Countries., Syeda Samnita Batool Zaidi, Umer Adnan, Kadriye O. Lewis, Syeda Sadia Fatima Dec 2024

Metaverse-Powered Basic Sciences Medical Education: Bridging The Gaps For Lower Middle-Income Countries., Syeda Samnita Batool Zaidi, Umer Adnan, Kadriye O. Lewis, Syeda Sadia Fatima

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Traditional medical education often lacks contextual experience, hindering students' ability to effectively apply theoretical knowledge in real-world scenarios. The integration of the metaverse into medical education holds great enormous promise for addressing educational disparities, particularly in lower-middle-income countries (LMICs) accompanied by rapid technological advancements. This commentary paper aimed to address the potential of the metaverse in enhancing basic sciences education within the constraints faced by universities in LMICs. We also addressed learning design challenges by proposing fundamental design elements and a suggested conceptual framework for developing metaverse-based teaching methods.The goal is to assist educators and medical practitioners in comprehensivley …


Corrosion Behavior Of Laser Powder Bed Fusion Additive Manufacturing Produced Tini Alloy By Micro-Arc Oxidation, Xin Zhao, Yicheng Liu, Chenfan Jia, Hao Chang, Wei Zhang, Yun Bai, Shujun Li, Lai-Chang Zhang, Wei Yuan Dec 2024

Corrosion Behavior Of Laser Powder Bed Fusion Additive Manufacturing Produced Tini Alloy By Micro-Arc Oxidation, Xin Zhao, Yicheng Liu, Chenfan Jia, Hao Chang, Wei Zhang, Yun Bai, Shujun Li, Lai-Chang Zhang, Wei Yuan

Research outputs 2022 to 2026

To improve the corrosion resistance of TiNi alloy fabricated by laser powder bed fusion (LPBF), a porous oxidation layer was synthesized by micro-arc oxidation in a sodium aluminate and sodium silicate electrolyte. The influences of the applied voltage and the processing time on the morphology of oxidation layer were investigated, and the corrosion behavior of the oxidation layer in artificial saliva was evaluated and compared with that of the as-fabricated LPBF alloy. The results indicate that, as increasing the applied voltage and the processing time, the oxidation layer becomes uniform and integrated. The optimum parameters are with an applied voltage …


Emotional And Behavioural Difficulties Among Children And Adolescents Attending “Art Teen Clubs” In Mzuzu City In Northern Malawi: A Cross-Sectional Study, Paul U. Kaseka, Maggie Zgambo, Balwani C. Mbakaya, Mathews Lazarus, Obed Nkhata, Fatch W. Kalembo Dec 2024

Emotional And Behavioural Difficulties Among Children And Adolescents Attending “Art Teen Clubs” In Mzuzu City In Northern Malawi: A Cross-Sectional Study, Paul U. Kaseka, Maggie Zgambo, Balwani C. Mbakaya, Mathews Lazarus, Obed Nkhata, Fatch W. Kalembo

Research outputs 2022 to 2026

Background: While triple anti-retroviral therapy (ART) has improved HIV-infected children surviving into adolescence and adulthood, these children remain vulnerable to HIV-related psychological disturbance due to both the direct HIV infection effects on the brain and indirect effects related to coping with a range of medical, psychological and social stresses associated with HIV, which makes it vital to identify their mental health needs. This study assessed the emotional and behavioural challenges of HIV perinatally infected children and adolescents with a completed disclosure process attending “ART teen club” in Malawi. Methods: A cross-sectional descriptive study design was conducted to obtain quantitative descriptive …


Measurement Of Cumulative High-Sensitivity C-Reactive Protein And Monocyte To High-Density Lipoprotein Ratio In The Risk Prediction Of Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Genyuan Chen, Yulong Lan, Shuohua Chen, Xiong Ding, Chiju Wei, Lois Balmer, Wei Wang, Shouling Wu, Wencan Xu Dec 2024

Measurement Of Cumulative High-Sensitivity C-Reactive Protein And Monocyte To High-Density Lipoprotein Ratio In The Risk Prediction Of Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Genyuan Chen, Yulong Lan, Shuohua Chen, Xiong Ding, Chiju Wei, Lois Balmer, Wei Wang, Shouling Wu, Wencan Xu

Research outputs 2022 to 2026

Background: Converging data have suggested that monocytic inflammation and C-reactive protein (CRP) are biologically intertwined processes and are involved in diabetogenesis. This study aimed to investigate the association between systemic inflammation assessed by joint cumulative high-sensitivity C-reactive protein (CumCRP) and monocyte to high-density lipoprotein ratio (CumMHR) and incident type 2 diabetes (T2D) and their predictive value for T2D in a general population. Methods: A total of 40,813 nondiabetic participants from a prospective real-life cohort (Kailuan Study, China) were followed biennially from 2010/2011 until December 31, 2020. Multivariable Cox regression analyses were conducted to evaluate the adjusted hazard ratios (aHRs) of …


Association Between Inflammatory Bowel Disease And Cancer Risk: Evidence Triangulation From Genetic Correlation, Mendelian Randomization, And Colocalization Analyses Across East Asian And European Populations, Di Liu, Meiling Cao, Haotian Wang, Weijie Cao, Chenguang Zheng, Yun Li, Youxin Wang Dec 2024

Association Between Inflammatory Bowel Disease And Cancer Risk: Evidence Triangulation From Genetic Correlation, Mendelian Randomization, And Colocalization Analyses Across East Asian And European Populations, Di Liu, Meiling Cao, Haotian Wang, Weijie Cao, Chenguang Zheng, Yun Li, Youxin Wang

Research outputs 2022 to 2026

Background: Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), has been associated with several cancer risks in observational studies, but the observed associations have been inconsistent and may face the bias of confounding and reverse causality. The potential causal relationships between IBD and the risk of cancers remain largely unclear. Methods: We performed genome-wide linkage disequilibrium score regression (LDSC), standard two-sample Mendelian randomization (MR), and colocalization analyses using summary genome-wide association study (GWAS) data across East Asian and European populations to evaluate the causal relationships between IBD and cancers. Sensitivity analyses for the MR approach …


Investment By Maternal Grandmother Buffers Children Against The Impacts Of Adverse Early Life Experiences, Samuli Helle, Antti O. Tanskanen, David A. Coall, Gretchen Perry, Martin Daly, Mirkka Danielsbacka Dec 2024

Investment By Maternal Grandmother Buffers Children Against The Impacts Of Adverse Early Life Experiences, Samuli Helle, Antti O. Tanskanen, David A. Coall, Gretchen Perry, Martin Daly, Mirkka Danielsbacka

Research outputs 2022 to 2026

Exogenous shocks during sensitive periods of development can have long-lasting effects on adult phenotypes including behavior, survival and reproduction. Cooperative breeding, such as grandparental care in humans and some other mammal species, is believed to have evolved partly in order to cope with challenging environments. Nevertheless, studies addressing whether grandparental investment can buffer the development of grandchildren from multiple adversities early in life are few and have provided mixed results, perhaps owing to difficulties drawing causal inferences from non-experimental data. Using population-based data of English and Welsh adolescents (sample size ranging from 817 to 1197), we examined whether grandparental investment …


Australasian Malignant Pleural Effusion (Ample)-4 Trial: Study Protocol For A Multi-Centre Randomised Trial Of Topical Antibiotics Prophylaxis For Infections Of Indwelling Pleural Catheters, Estee P. M. Lau, Matthew Ing, Sona Vekaria, Ai L. Tan, Chloe Charlesworth, Edward Fysh, Ranjan Shrestha, Elaine L. C. Yap, Nicola A. Smith, Benjamin C. H. Kwan, Tajalli Saghaie, Bapti Roy, John Goddard, Sanjeevan Muruganandan, Arash Badiei, Phan Nguyen, Mohamed F. A. Hamid, Vineeth George, Deirdre Fitzgerald, Nick Maskell, David Feller-Kopman, Kevin Murray, Aron Chakera, Y. C. Gary Lee Dec 2024

Australasian Malignant Pleural Effusion (Ample)-4 Trial: Study Protocol For A Multi-Centre Randomised Trial Of Topical Antibiotics Prophylaxis For Infections Of Indwelling Pleural Catheters, Estee P. M. Lau, Matthew Ing, Sona Vekaria, Ai L. Tan, Chloe Charlesworth, Edward Fysh, Ranjan Shrestha, Elaine L. C. Yap, Nicola A. Smith, Benjamin C. H. Kwan, Tajalli Saghaie, Bapti Roy, John Goddard, Sanjeevan Muruganandan, Arash Badiei, Phan Nguyen, Mohamed F. A. Hamid, Vineeth George, Deirdre Fitzgerald, Nick Maskell, David Feller-Kopman, Kevin Murray, Aron Chakera, Y. C. Gary Lee

Research outputs 2022 to 2026

Background: Malignant pleural effusion (MPE) is a debilitating condition as it commonly causes disabling breathlessness and impairs quality of life (QoL). Indwelling pleural catheter (IPC) offers an effective alternative for the management of MPE. However, IPC-related infections remain a significant concern and there are currently no long-term strategies for their prevention. The Australasian Malignant PLeural Effusion (AMPLE)-4 trial is a multicentre randomised trial that evaluates the use of topical mupirocin prophylaxis (vs no mupirocin) to reduce catheter-related infections in patients with MPE treated with an IPC. Methods: A pragmatic, multi-centre, open-labelled, randomised trial. Eligible patients with MPE and an IPC …


Intrinsic Motivation In A Virtual Reality Mock Crime Affects Participants’ Willingness To Invest More Effort In Deceptive Interviews, Isabella S. Branson, Craig P. Speelman, Shane L. Rogers Dec 2024

Intrinsic Motivation In A Virtual Reality Mock Crime Affects Participants’ Willingness To Invest More Effort In Deceptive Interviews, Isabella S. Branson, Craig P. Speelman, Shane L. Rogers

Research outputs 2022 to 2026

In studies of investigative interviewing, it is not well understood how participant experience of mock-crime activities might affect participants’ desire to perform (well) in subsequent interviews. In this study, we utilized two immersive virtual reality mock-crimes to examine if participants’ intrinsic motivation (i.e., competence, autonomy, relatedness) while committing the virtual mock-crime affects their desire to perform well in interviews. We also examined if the self-reported feeling of presence during the virtual reality mock-crime is associated with participants’ intrinsic motivation. We found significant positive associations between presence and all intrinsic motivation variables in both truth and lie conditions. We also found …


A Secure Cross-Domain Authentication Scheme Based On Threshold Signature For Mec, Lei Chen, Chong Guo, Bei Gong, Muhammad Waqas, Lihua Deng, Haowen Qin Dec 2024

A Secure Cross-Domain Authentication Scheme Based On Threshold Signature For Mec, Lei Chen, Chong Guo, Bei Gong, Muhammad Waqas, Lihua Deng, Haowen Qin

Research outputs 2022 to 2026

The widespread adoption of fifth-generation mobile networks has spurred the rapid advancement of mobile edge computing (MEC). By decentralizing computing and storage resources to the network edge, MEC significantly enhances real-time data access services and enables efficient processing of large-scale dynamic data on resource-limited devices. However, MEC faces considerable security challenges, particularly in cross-domain service environments, where every device poses a potential security threat. To address this issue, this paper proposes a secure cross-domain authentication scheme based on a threshold signature tailored to MEC’s multi-subdomain nature. The proposed scheme employs a (t,n) threshold mechanism to bolster system resilience and security, …


Exploring Treatment Burden In People With Type 2 Diabetes Mellitus: A Thematic Analysis In China's Primary Care Settings, Kai Lin, Mi Yao, Lesley Andrew, Rouyan Li, Yilin Chen, Jacques Oosthuizen, Moira Sim, Yongsong Chen Dec 2024

Exploring Treatment Burden In People With Type 2 Diabetes Mellitus: A Thematic Analysis In China's Primary Care Settings, Kai Lin, Mi Yao, Lesley Andrew, Rouyan Li, Yilin Chen, Jacques Oosthuizen, Moira Sim, Yongsong Chen

Research outputs 2022 to 2026

Background: Understanding treatment burden is a critical element to the effective management of Type 2 Diabetes Mellitus (T2DM). The current study aims to address the knowledge gap surrounding treatment burden of T2DM from the patient’s perspective in China’s primary care settings. Methods: A narrative review informed the creation of an a priori coding structure to identify aspects of T2DM treatment burden. Focus groups were conducted, employing a maximum variation sampling strategy to select participants from diverse sociodemographic backgrounds across urban, suburban, rural, and remote areas in China. Participants included adults with T2DM care in primary care settings for over a …


Prevalence And Risk Factors Of Obesity Among Undergraduate Student Population In Ghana: An Evaluation Study Of Body Composition Indices, Christian Obirikorang, Evans A. Adu, Enoch O. Anto, Anthony A. A. Awuah, Angela N. B. Fynn, George Osei-Somuah, Patience N. Ansong, Alexander O. Boakye, Ivy Ofori-Boadu, Yaa Obirikorang, Austin G. Adobasom-Anane, Eric N. Y. Nyarko, Lois Balmer Dec 2024

Prevalence And Risk Factors Of Obesity Among Undergraduate Student Population In Ghana: An Evaluation Study Of Body Composition Indices, Christian Obirikorang, Evans A. Adu, Enoch O. Anto, Anthony A. A. Awuah, Angela N. B. Fynn, George Osei-Somuah, Patience N. Ansong, Alexander O. Boakye, Ivy Ofori-Boadu, Yaa Obirikorang, Austin G. Adobasom-Anane, Eric N. Y. Nyarko, Lois Balmer

Research outputs 2022 to 2026

Background: Obesity is a classified risk factor for several of the world’s leading causes of death. In this study, we combined information contained in body mass index (BMI), total percentage body fat (TPBF) and relative fat mass (RFM) to estimate obesity prevalence and examine the risk factors associated with obesity. Methods: The study recruited 1027 undergraduate students aged between 16 and 25 years using a cross-sectional study design and two-stage stratified random sampling between January and April 2019 from the Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Demographic, lifestyle, and family history of chronic disease data, were collected …


Exploring Post-Covid-19 Health Effects And Features With Advanced Machine Learning Techniques, Muhammad N. Islam, Md S. Islam, Nahid H. Shourav, Iftiaqur Rahman, Faiz A. Faisal, Md M. Islam, Iqbal H. Sarker Dec 2024

Exploring Post-Covid-19 Health Effects And Features With Advanced Machine Learning Techniques, Muhammad N. Islam, Md S. Islam, Nahid H. Shourav, Iftiaqur Rahman, Faiz A. Faisal, Md M. Islam, Iqbal H. Sarker

Research outputs 2022 to 2026

COVID-19 is an infectious respiratory disease that has had a significant impact, resulting in a range of outcomes including recovery, continued health issues, and the loss of life. Among those who have recovered, many experience negative health effects, particularly influenced by demographic factors such as gender and age, as well as physiological and neurological factors like sleep patterns, emotional states, anxiety, and memory. This research aims to explore various health factors affecting different demographic profiles and establish significant correlations among physiological and neurological factors in the post-COVID-19 state. To achieve these objectives, we have identified the post-COVID-19 health factors and …


Jamming Precoding In Af Relay-Aided Plc Systems With Multiple Eavessdroppers, Zhengmin Kong, Jiaxing Cui, Li Ding, Tao Huang, Shihao Yan Dec 2024

Jamming Precoding In Af Relay-Aided Plc Systems With Multiple Eavessdroppers, Zhengmin Kong, Jiaxing Cui, Li Ding, Tao Huang, Shihao Yan

Research outputs 2022 to 2026

Enhancing information security has become increasingly significant in the digital age. This paper investigates the concept of physical layer security (PLS) within a relay-aided power line communication (PLC) system operating over a multiple-input multiple-output (MIMO) channel based on MK model. Specifically, we examine the transmission of confidential signals between a source and a distant destination while accounting for the presence of multiple eavesdroppers, both colluding and non-colluding. We propose a two-phase jamming scheme that leverages a full-duplex (FD) amplify-and-forward (AF) relay to address this challenge. Our primary objective is to maximize the secrecy rate, which necessitates the optimization of the …


Spatial Transcriptomics Reveals Discrete Tumour Microenvironments And Autocrine Loops Within Ovarian Cancer Subclones, Elena Denisenko, Leanne De Kock, Adeline Tan, Aaron B. Beasley, Maria Beilin, Matthew E. Jones, Rui Hou, Dáithí Ó Muirí, Sanela Bilic, G. Raj K. A. Mohan, Stuart Salfinger, Simon Fox, Khaing P. W. Hmon, Yen Yeow, Youngmi Kim, Rhea John, Tami S. Gilderman, Emily Killingbeck, Elin S. Gray, Paul A. Cohen, Yu Yu, Alistair R. R. Forrest Dec 2024

Spatial Transcriptomics Reveals Discrete Tumour Microenvironments And Autocrine Loops Within Ovarian Cancer Subclones, Elena Denisenko, Leanne De Kock, Adeline Tan, Aaron B. Beasley, Maria Beilin, Matthew E. Jones, Rui Hou, Dáithí Ó Muirí, Sanela Bilic, G. Raj K. A. Mohan, Stuart Salfinger, Simon Fox, Khaing P. W. Hmon, Yen Yeow, Youngmi Kim, Rhea John, Tami S. Gilderman, Emily Killingbeck, Elin S. Gray, Paul A. Cohen, Yu Yu, Alistair R. R. Forrest

Research outputs 2022 to 2026

High-grade serous ovarian carcinoma (HGSOC) is genetically unstable and characterised by the presence of subclones with distinct genotypes. Intratumoural heterogeneity is linked to recurrence, chemotherapy resistance, and poor prognosis. Here, we use spatial transcriptomics to identify HGSOC subclones and study their association with infiltrating cell populations. Visium spatial transcriptomics reveals multiple tumour subclones with different copy number alterations present within individual tumour sections. These subclones differentially express various ligands and receptors and are predicted to differentially associate with different stromal and immune cell populations. In one sample, CosMx single molecule imaging reveals subclones differentially associating with immune cell populations, fibroblasts, …