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Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization In The Prelimbic Cortex, Jayme R. Mcreynolds, Elizabeth M. Doncheck, Yan Li, Oliver Vranjkovic, Evan N. Graf, Daisuke Ogasawara, Benjamin F. Cravatt, David A. Baker, Qing-Song Liu, Cecilia J. Hillard, John R. Mantsch
Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization In The Prelimbic Cortex, Jayme R. Mcreynolds, Elizabeth M. Doncheck, Yan Li, Oliver Vranjkovic, Evan N. Graf, Daisuke Ogasawara, Benjamin F. Cravatt, David A. Baker, Qing-Song Liu, Cecilia J. Hillard, John R. Mantsch
Biological Sciences Faculty Research and Publications
Background
Clinical reports suggest that rather than directly driving cocaine use, stress may create a biological context within which other triggers for drug use become more potent. We hypothesize that stress-induced increases in corticosterone “set the stage” for relapse by promoting endocannabinoid-induced attenuation of inhibitory transmission in the prelimbic cortex (PL).
Methods
We have established a rat model for these stage-setting effects of stress. In this model, neither a stressor (electric footshock) nor stress-level corticosterone treatment alone reinstates cocaine seeking following self-administration and extinction, but each treatment potentiates reinstatement in response to an otherwise subthreshold cocaine priming dose (2.5 mg/kg, …
Verbal Memory Performance And Reduced Cortical Thickness Of Brain Regions Along The Uncinate Fasciculus In Young Adult Cannabis Users, Nina Levar, Alan N. Francis, Matthew J. Smith, Wilson C. Ho, Jodi M. Gilman
Verbal Memory Performance And Reduced Cortical Thickness Of Brain Regions Along The Uncinate Fasciculus In Young Adult Cannabis Users, Nina Levar, Alan N. Francis, Matthew J. Smith, Wilson C. Ho, Jodi M. Gilman
School of Medicine Publications and Presentations
Introduction: Memory impairment is one of the most commonly reported effects of cannabis use, especially among those who initiate use earlier, perhaps due to the effects of delta-9- tetrahydrocannabinol on cannabinoid (CB1) receptors in the brain. Studies have increasingly investigated whether cannabis use is associated with impairments in verbal memory, and with alterations in brain structures underlying verbal memory. The uncinate fasciculus (UF), a long-range white matter tract, connects regions with densely localized CB1 receptors that are important in verbal memory. This study investigated the impact of cannabis use on UF structures and its association with memory performance in young …