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A Qualitative Analysis Of The Health Informatics Role In Addressing The Public Health Crisis Of Addiction And Overall Effectiveness Of Treatment, Daniel Del Toro

Applied Research Projects

In recent years, the implementation of Health Information Management (HIM) data systems has had significant positive impacts in nearly all aspects of both health and healthcare delivery. However, during this time, there has also been a dramatic increase in the demand for addiction and mental health treatment. The rising number of individuals requiring mental health treatment for addiction has resulted in its declaration as an urgent public health epidemic by the Department of Health and Human Services. The all-encompassing effects of addiction are prevalent in all areas of society, seen in the form of across-the-board rising healthcare costs, addiction related …

Inter-Relationships Linking Probability Of Becoming A Case Of Nicotine Dependence With Frequency Of Tobacco Cigarette Smoking, Olga A. Vsevolozhskaya, James C. Anthony

Biostatistics Faculty Publications

INTRODUCTION: Once smoking starts, some tobacco cigarette smokers (TCS) can make very rapid transitions into tobacco dependence syndromes (TCD). With adjustment for smoking frequency, we posit female excess risk for this rapid-onset TCD. In a novel application of functional analysis for tobacco research, we estimate four Hill function parameters and plot TCD risk against a gradient of smoking frequency, as observed quite soon after smoking onset.

METHODS: In aggregate, the National Surveys of Drug Use and Health, 2004-2013, identified 1546 newly incident TCS in cross-sectional research, each with standardized TCD assessment.

RESULTS: Hill function estimates contradict our apparently over-simplistic hypothesis. …

Implementing An Mhealth System For Substance Use Disorders In Primary Care: A Mixed Methods Study Of Clinicians’ Initial Expectations And First Year Experiences, Marie-Louise Mares, David H. Gustafson, Joseph E. Glass, Andrew Quanbeck, Helene Mcdowell, Fiona Mctavish, Amy K. Atwood, Lisa A. Marsch, Chanetelle Thomas, Dhavan Shah, Randall Brown, Andrew Isham, Mary Jane Nealon, Victoria Ward

Publications and Research

Background: Millions of Americans need but don’t receive treatment for substance use, and evidence suggests that addiction-focused interventions on smart phones could support their recovery. There is little research on implementation of addiction-related interventions in primary care, particularly in Federally Qualified Health Centers (FQHCs) that provide primary care to underserved populations. We used mixed methods to examine three FQHCs’ implementation of Seva, a smart-phone app that offers patients online support/discussion, health-tracking, and tools for coping with cravings, and offers clinicians information about patients’ health tracking and relapses. We examined (a) clinicians’ initial perspectives about implementing Seva, and (b) the first …

Stress-Induced Executive Dysfunction In Gdnf-Deficient Mice, A Mouse Model Of Parkinsonism, Mona Buhusi, Kaitlin Olsen, Benjamin Z. Young, Catalin V. Buhusi

Psychology Faculty Publications

Maladaptive reactivity to stress is linked to improper decision making, impulsivity, and discounting of delayed rewards. Chronic unpredictable stress alters dopaminergic function and re-shapes dopaminergic circuits in key areas involved in decision making, and impairs prefrontal-cortex dependent response inhibition and working memory. Glial-derived neurotrophic factor (GDNF) is essential for regulating dopamine release in the basal ganglia and the survival of dopaminergic neurons, and GDNF-deficient mice are considered an animal model for aging-related Parkinsonism. Recently, GDNF expression in the striatum has been linked to resilience to stress. Here we investigated the effects of chronic unpredictable stress on decision making in GDNF-heterozygous …

Impact Of Pornography Use In Adolescent Boys: Boys’ Self-Reports On Their Use Of Pornography, Sarah R. Sangeado

Senior Honors Projects

Pornography use has become more prevalent in recent years and research has shown that excessive use can lead to addictive behaviors. This is of special concern for adolescents, who are more vulnerable to addiction because of their immature brains and heightened response to visual stimuli. This study is an inquiry into what adolescent boys are saying about pornography’s effect on their sexual and social functioning. A content analysis was done on messages from online pornography forums written by adolescent boys 19 years of age and younger. A total of 125 comments were extracted and placed into six different categories: 1) …

Cb1 Receptor Antagonism Blocks Stress-Potentiated Reinstatement Of Cocaine Seeking In Rats, Jayme R. Mcreynolds, Elizabeth M. Doncheck, Oliver Vranjkovic, Geoffrey S. Ganzman, David A. Baker, Cecilia J. Hillard, John R. Mantsch

Biomedical Sciences Faculty Research and Publications

Rationale

Under some conditions, stress, rather than directly triggering cocaine seeking, potentiates reinstatement to other stimuli, including a subthreshold cocaine dose. The mechanisms responsible for stress-potentiated reinstatement are not well defined. Endocannabinoid signaling is increased by stress and regulates synaptic transmission in brain regions implicated in motivated behavior.

Objectives

The objective of this study was to test the hypothesis that cannabinoid type 1 receptor (CB1R) signaling is required for stress-potentiated reinstatement of cocaine seeking in rats.

Methods

Following i.v. cocaine self-administration (2 h access/day) and extinction in male rats, footshock stress alone does not reinstate cocaine seeking but reinstatement is …

Genetic Imaging Consortium For Addiction Medicine: From Neuroimaging To Genes, Scott Mackey, Kees-Jan Kan, Bader Chaarani, Nelly Alia-Klein, Albert Batalla, Samantha Brooks, Janna Cousijn, Alain Dagher, Michiel De Ruiter, Sylvane Desrivieres, Sarah W. Feldstein Ewing, Rita Goldstein, Anna Goudriaan, Mary M. Heitzeg, Kent Hutchison, Chiang-Shan R. Li, Edythe D. London, Valentina Lorenzetti, Maartje Luijten, Rocio Martin-Santos, Angelica M. Morales, Martin P. Paulus, Tomas Paus, Godfrey Pearlson, Renee Schluter, Reza Momenan, Lianne Schmaal, Gunter Schumann, Rajita Sinha, Zsuzsika Sjoerds, Dan J. Stein, Elliot A. Stein, Nadia Solowij, Susan Tapert, Anne Uhlmann, Dick Veltman, Ruth Van Holst, Hendrik Walter, Margaret J. Wright, Murat Yucel, Murat Yucel, Deborah Yurgelun-Todd, Derrek P. Hibar, Neda Jahanshad, Paul M. Thompson, David Glahn, Hugh Garavan, Patricia Conrod

Faculty of Social Sciences - Papers (Archive)

Since the sample size of a typical neuroimaging study lacks sufficient statistical power to explore unknown genomic associations with brain phenotypes, several international genetic imaging consortia have been organized in recent years to pool data across sites. The challenges and achievements of these consortia are considered here with the goal of leveraging these resources to study addiction. The authors of this review have joined together to form an Addiction working group within the framework of the ENIGMA project, a meta-analytic approach to multisite genetic imaging data. Collectively, the Addiction working group possesses neuroimaging and genomic data obtained from over 10,000 …

Prevalence And Predictors Of Substance-Related Emergency Psychiatry Admissions, M. Scott Young, Kathleen A. Moore

Mental Health Law & Policy Faculty Publications

Background: Individuals commonly present for emergency psychiatry services for reasons related to their use of alcohol or illicit drugs. This study assessed the prevalence of these phenomena and explored characteristics distinguishing emergency psychiatry admissions with versus without presenting problems related to substance use. Methods: Data included standardized emergency psychiatry intake interviews from 2,161 consecutive admissions to three hospital-based emergency psychiatry departments in Florida’s Tampa Bay area. Admissions were classified as substanceinvolved if substance use was ascertained to be related to the presenting problem(s). Cases with only substance-related presenting problems were classified as substance-only admissions. Descriptive statistics compared substance-involved admissions to …